A facile chemoenzymatic approach: one-step syntheses of monoterpenoid indole alkaloids.

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Chemistry - An Asian Journal

• Publication date

  2010-11-02

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1002/asia.201000520PMID 20872397
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Improved Expression of His6‐Tagged Strictosidine Synthase cDNA for Chemo‐Enzymatic Alkaloid Diversification

  2010cited by this paper
• A practical chemo-enzymatic synthesis of homochiral bicyclo[2.2.2]octane-2,5-dione.

  2010cited by this paper
• Synthesis of 4-, 5-, 6-, and 7-Azidotryptamines.

  2009cited by this paper
• Aza-tryptamine substrates in monoterpene indole alkaloid biosynthesis.

  2009cited by this paper
• Late‐onset vanishing white matter disease with compound heterozygous EIF2B5 gene mutations

  2009cited by this paper
• A chemistry cascade: from physical organic studies of alkoxy radicals to alkaloid synthesis.

  2009cited by this paper
• Cell division cycle 7 kinase inhibitors: 1H-pyrrolo[2,3-b]pyridines, synthesis and structure-activity relationships.

  2009cited by this paper
• Strictosidine synthase: mechanism of a Pictet-Spengler catalyzing enzyme.

  2008cited by this paper
• Design, synthesis and development of novel camptothecin drugs.

  2008cited by this paper
• Meriolins (3-(pyrimidin-4-yl)-7-azaindoles): synthesis, kinase inhibitory activity, cellular effects, and structure of a CDK2/cyclin A/meriolin complex.

  2008cited by this paper
• Structural biology in plant natural product biosynthesis--architecture of enzymes from monoterpenoid indole and tropane alkaloid biosynthesis.

  2007cited by this paper
• Structure-based engineering of strictosidine synthase: auxiliary for alkaloid libraries.

  2007cited by this paper
• Catalytic asymmetric Pictet-Spengler reaction.

  2006cited by this paper
• Redesign of a central enzyme in alkaloid biosynthesis.

  2006cited by this paper
• Substrate specificity of strictosidine synthase.

  2006cited by this paper
• Design, synthesis, and SAR analysis of cytotoxic sinapyl alcohol derivatives.

  2006cited by this paper
• New Strategies for the Synthesis of Monoterpene Indole Alkaloids

  2005cited by this paper
• Plants as a source of anti-cancer agents.

  2005cited by this paper
• Enantioselective enzymatic desymmetrizations in organic synthesis.

  2005cited by this paper
• Crystallization and preliminary X-ray crystallographic analysis of strictosidine synthase from Rauvolfia: the first member of a novel enzyme family.

  2004cited by this paper
• Towards new anticancer drugs: a decade of advances in synthesis of camptothecins and related alkaloids

  2003cited by this paper
• Evaluation of eight in vitro assays for assessing the cytotoxicity of cigarette smoke condensate.

  2002cited by this paper
• Synthesis and Reactivity of 7-Azaindole (1H-Pyrrolo[2,3-b]pyridine)

  2001cited by this paper
• Configurative correlation and conformational analysis of strictosidine and vincoside derivatives

  1999cited by this paper
• A concise strategy for the syntheses of indole alkaloids of the heteroyohimboid and corynantheioid families. Total syntheses of (.+-.)-tetrahydroalstonine, (.+-.)-cathenamine and (.+-.)-geissoschizine

  1988cited by this paper
• Immobilization of Strictosidine Synthase from Catharanthus Cell Cultures and Preparative Synthesis of Strictosidine

  1982cited by this paper
• Enzymatic formation of intermediates in the biosynthests of ajmalicine: Strictosidine and cathenamine

  1979cited by this paper
• Alternative cyclisation of 3α- and 3β- indole alkaloid glucosides

  1975cited by this paper

• β-Methyltryptamine Provoking the Crucial Role of Strictosidine Synthase Tyr151-OH for Its Stereoselective Pictet-Spengler Reactions to Tryptoline-type Alkaloids.

  2022cites this paper
• Total Synthesis of (-)-Strictosidine and Interception of Aryne Natural Product Derivatives "Strictosidyne" and "Strictosamidyne".

  2021cites this paper
• Bioinspired Transformations Using Strictosidine Aglycones: Divergent Total Syntheses of Monoterpenoid Indole Alkaloids in the Early Stage of Biosynthesis.

  2021cites this paper
• Privileged biorenewable secologanin-based diversity-oriented synthesis for pseudo-natural alkaloids: uncovering novel neuroprotective and antimalarial frameworks.

  2021cites this paper
• A Reappraisal of the Structure of Lyaline as the First Naturally Occurring Nacycline Monoterpene Indole Alkaloid.

  2021cites this paper
• Recent advances in biocatalysis of nitrogen-containing heterocycles.

  2021cites this paper
• Computational Study of Pictet–Spenglerase Strictosidine Synthase: Reaction Mechanism and Origins of Enantioselectivity of Natural and Non-Natural Substrates

  2020cites this paper
• Bioinspired Divergent Oxidative Cyclization from Strictosidine and Vincoside Derivatives: Second Generation Total Synthesis of Cymoside and Access to an Original Hexacyclic-Fused Furo[3,2-b]indoline.

  2020cites this paper
• Stereocomplementary Chemoenzymatic Pictet–Spengler Reactions for Formation of Rare Azepino-indole Frameworks: Discovery of Antimalarial Compounds

  2019cites this paper
• Biocatalyzed C−C Bond Formation for the Production of Alkaloids

  2018cites this paper
• Computer aided drug discovery tools and pipelines for molecule targeted inhibition of Topoisomerases I and II in cancer

  2018cites this paper
• Asymmetric Synthesis of (R)‐1‐Alkyl‐Substituted Tetrahydro‐ß‐carbolines Catalyzed by Strictosidine Synthases

  2018cites this paper
• Library of Norcoclaurine Synthases and Their Immobilization for Biocatalytic Transformations.

  2018cites this paper
• Strictosidine Synthase Triggered Enantioselective Synthesis of N-Substituted (S)-3,14,18,19-Tetrahydroangustines as Novel Topoisomerase I Inhibitors.

  2017cites this paper
• Building Bridges: Biocatalytic C–C-Bond Formation toward Multifunctional Products

  2016cites this paper
• Sarpagan-Ajmalan-Type Indoles: Biosynthesis, Structural Biology, and Chemo-Enzymatic Significance.

  2016cites this paper
• Biocatalysts for the formation of three- to six-membered carbo- and heterocycles.

  2015cites this paper
• Expression, crystallization and preliminary X-ray analysis of McbB, a multifunctional enzyme involved in β-carboline skeleton biosynthesis.

  2014cites this paper
• Using Strictosidine Synthase to Prepare Novel Alkaloids.

  2014cites this paper
• The role of biocatalysis in the asymmetric synthesis of alkaloids

  2013cites this paper
• Tetrahydroalstonine

  2013cites this paper
• Scaffold tailoring by a newly detected Pictet-Spenglerase activity of strictosidine synthase: from the common tryptoline skeleton to the rare piperazino-indole framework.

  2012cites this paper
• Crystal Structure of Perakine Reductase, Founding Member of a Novel Aldo-Keto Reductase (AKR) Subfamily That Undergoes Unique Conformational Changes during NADPH Binding*

  2012cites this paper
• The Pictet-Spengler reaction in nature and in organic chemistry.

  2011cites this paper
• Synthesis and biological evaluation of 2-indolinone derivatives as potential antitumor agents.

  2011cites this paper
• Die Pictet‐Spengler‐Reaktion in der Natur und der organischen Chemie

  2011cites this paper