Model‐Based Reverse Translation Between Veterinary and Human Medicine: The One Health Initiative

There is growing concern about the limitations of rodent models with regard to recapitulation of human disease pathogenesis. Computational modeling of data from humans and animals sharing similar diseases provides an opportunity for parallel drug development in human and veterinary medicine. This “reverse translational” approach needs to be supported by continuing efforts to refine the in silico tools that allow extrapolation of results between species.

• Publication year

  2017

• Venue

  CPT: Pharmacometrics & Systems Pharmacology

• Publication date

  2017-11-27

• Fields of study

  Medicine, Computer Science

• Identifiers
  DOI 10.1002/psp4.12262PMID 29178333PMCID 5824107
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Researchers Turn to Canine Clinical Trials to Advance Cancer Therapies.

  2016cited by this paper
• Defining the Pharmacodynamic Profile and Therapeutic Index of NHS-IL12 Immunocytokine in Dogs with Malignant Melanoma

  2015cited by this paper
• An analysis of the attrition of drug candidates from four major pharmaceutical companies

  2015cited by this paper
• Gene Electrotransfer of Canine Interleukin 12 into Canine Melanoma Cell Lines

  2015cited by this paper
• From the Centers for Disease Control and Prevention

  2015cited by this paper
• Meta-analysis: Critical Appraisal

  2014cited by this paper
• Renin-Angiotensin Aldosterone Biomarkers Following Angiotensin-Converting Enzyme ( ACE ) Inhibition Therapy with Benazepril in Dogs

  2014influential reference
• Sentinel Surveillance of Influenza-Like-Illness in Two Cities of the Tropical Country of Ecuador: 2006–2010

  2011cited by this paper
• The Comparative Oncology Trials Consortium: Using Spontaneously Occurring Cancers in Dogs to Inform the Cancer Drug Development Pathway

  2009cited by this paper
• Intestinal cytokine mRNA expression in canine inflammatory bowel disease: a meta-analysis with critical appraisal.

  2009cited by this paper
• Canine Nutritional Model: Influence of Age, Diet, and Genetics on Health and Well-Being

  2006cited by this paper

• Canine urothelial cell model to study intracellular bacterial community development by uropathogenic Escherichia coli

  2025cites this paper
• Artificial Intelligence in Veterinary Surgical Research: Current Applications and Prospects

  2025cites this paper
• Establishment and transcriptomic characterization of canine organoids from multiple tissues

  2025cites this paper
• Canábis como conexão entre sustentabilidade e saúde: explorando seu potencial no Modelo One Health

  2025cites this paper
• From bench to bedside and back: translational cardiovascular interventions in veterinary medicine

  2025influential citation
• Organoid: Biomedical application, biobanking, and pathways to translation

  2025cites this paper
• Cisplatin-Induced Metabolic Responses Measured with Raman Spectroscopy in Cancer Cells, Spheroids, and Canine-Derived Organoids.

  2024cites this paper
• Preclinical modeling of metabolic syndrome to study the pleiotropic effects of novel antidiabetic therapy independent of obesity

  2024cites this paper
• Optimización del régimen de dosificación de antibióticos a través de la integración farmacocinética/farmacodinámica: una revisión

  2024cites this paper
• Adult Animal Stem Cell-Derived Organoids in Biomedical Research and the One Health Paradigm

  2024influential citation
• Canine mammary carcinoma: current therapeutic targets and future perspectives – a review

  2023cites this paper
• Banking on a new understanding: translational opportunities from veterinary biobanks

  2023cites this paper
• Breakthrough: a first-in-class virtual simulator for dose optimization of ACE inhibitors in translational cardiovascular medicine

  2023cites this paper
• Establishment and Characterization of Novel Canine Organoids with Organ-Specific Physiological Similarity

  2022cites this paper
• Breakthrough: A First-In-Class Virtual Simulator for Dose Optimization of ACE Inhibitors in Veterinary Cardiology

  2022cites this paper
• Nutritional Effects on the Gut Microbiome & the Brain-Gut Axis: Unlocking the Therapeutic and Preventative Potential of Nutrition for Gut Dysbiosis Associated Diseases

  2021cites this paper
• Comparison of Canine and Human Physiological Factors: Understanding Interspecies Differences that Impact Drug Pharmacokinetics

  2021cites this paper
• The Role of PK/PD Analysis in the Development and Evaluation of Antimicrobials

  2021cites this paper
• Gene Editing and Gene Therapy: Entering Uncharted Territory in Veterinary Oncology

  2021cites this paper
• Cannabis, One Health, and Veterinary Medicine: Cannabinoids’ Role in Public Health, Food Safety, and Translational Medicine

  2020cites this paper
• Feline cognitive dysfunction as a model for Alzheimer’s disease in the research of CBD as a potential treatment—a narrative review

  2020cites this paper
• Comprehensive Joint Modeling of First-Line Therapeutics in Non-Small Cell Lung Cancer

  2020cites this paper
• An eye on the dog as a translational model for ocular pharmacology

  2020cites this paper
• Non-Linear Mixed-Effects Pharmacokinetic Modeling of the Novel COX-2 Selective Inhibitor Vitacoxib in Cats

  2020cites this paper
• Animal models of Chagas disease and their translational value to drug development

  2020cites this paper
• An eye on the dog as the scientist's best friend for translational research in ophthalmology: Focus on the ocular surface

  2020cites this paper
• Considerations in the extrapolation of drug toxicity between humans and dogs

  2020cites this paper
• Model-Informed Drug Discovery and Development Strategy for the Rapid Development of Anti-Tuberculosis Drug Combinations

  2020cites this paper
• Recapitulation of the accessible interface of biopsy-derived canine intestinal organoids to study epithelial-luminal interactions

  2020cites this paper
• A Review of Relevant Therapeutic Targets for the Management of Congestive Heart Failure in Dogs: Present and Future Directions

  2019cites this paper
• Prediction Methods of Herbal Compounds in Chinese Medicinal Herbs

  2018cites this paper
• CAR T Cell Immunotherapy in Human and Veterinary Oncology: Changing the Odds Against Hematological Malignancies

  2018cites this paper
• The Safety of an Adjuvanted Autologous Cancer Vaccine Platform in Canine Cancer Patients

  2018influential citation
• Reverse Translational Pharmacology Research Is Driven by Big Data

  2018cites this paper