Collagenase-1 complexes with alpha2-macroglobulin in the acute and chronic wound environments.

No abstract is available for this paper.

• Publication year

  1998

• Venue

  Journal of Investigative Dermatology

• Publication date

  1998-05-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1046/J.1523-1747.1998.00192.XPMID 9579544
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Matrix degrading metalloproteinases

  2005cited by this paper
• Identification of proteinase 3 as the major caseinolytic activity in acute human wound fluid.

  1998cited by this paper
• The Activity of Collagenase-1 Is Required for Keratinocyte Migration on a Type I Collagen Matrix

  1997cited by this paper
• Fibronectin Degradation in Chronic Wounds Depends on the Relative Levels of Elastase, α1-Proteinase Inhibitor, and α2-Macroglobulin

  1996cited by this paper
• Wound fluids from human pressure ulcers contain elevated matrix metalloproteinase levels and activity compared to surgical wound fluids.

  1996cited by this paper
• Regulating expression of the gene for matrix metalloproteinase-1 (collagenase): mechanisms that control enzyme activity, transcription, and mRNA stability.

  1996cited by this paper
• The roles of tissue inhibitors of metalloproteinases in tissue remodelling and cell growth.

  1996cited by this paper
• Fibronectin degradation in chronic wounds depends on the relative levels of elastase, alpha1-proteinase inhibitor, and alpha2-macroglobulin.

  1996cited by this paper
• Matrix metalloproteinases, gelatinase and collagenase, in chronic leg ulcers.

  1996cited by this paper
• Metalloproteinase inhibitors and the prevention of connective tissue breakdown.

  1996cited by this paper
• Biochemical analysis of acute and chronic wound environments

  1996cited by this paper
• Patterns of matrix metalloproteinase and TIMP‐1 expression in chronic and normally healing human cutaneous wounds

  1996cited by this paper
• Interstitial collagenase is expressed by keratinocytes that are actively involved in reepithelialization in blistering skin disease.

  1995cited by this paper
• Alpha 1-antitrypsin is degraded and non-functional in chronic wounds but intact and functional in acute wounds: the inhibitor protects fibronectin from degradation by chronic wound fluid enzymes.

  1995cited by this paper
• Collagenase expression is rapidly induced in wound-edge keratinocytes after acute injury in human skin, persists during healing, and stops at re-epithelialization.

  1995cited by this paper
• Tissue inhibitor of metalloproteinases-1 is decreased and activated gelatinases are increased in chronic wounds.

  1995cited by this paper
• Evidence of a direct relationship between neutrophil collagenase activity and periodontal tissue destruction in vivo: role of active enzyme in human periodontitis.

  1995cited by this paper
• Determination of Endogenous Cytokines in Chronic Wounds

  1994cited by this paper
• Localization of mRNAs representing interstitial collagenase, 72-kda gelatinase, and TIMP in healing porcine burn wounds.

  1994cited by this paper
• The Proteinase‐Binding Reaction of α2M

  1994cited by this paper
• Interaction of α2‐Macroglobulin with Matrix Metalloproteinases and Its Use for Identification of Their Active Forms a

  1994cited by this paper
• Mutational analysis of residues in and around the active site of human fibroblast-type collagenase.

  1994cited by this paper
• Interaction of alpha 2-macroglobulin with matrix metalloproteinases and its use for identification of their active forms.

  1994cited by this paper
• Identification of neutrophil elastase as the proteinase in burn wound fluid responsible for degradation of fibronectin.

  1994cited by this paper
• Metalloproteinase activation cascade after burn injury: a longitudinal analysis of the human wound environment.

  1994cited by this paper
• High free and latent collagenase activity in psoriatic arthritis synovial fluids.

  1994cited by this paper
• Workshop on the pathogenesis of chronic wounds.

  1994cited by this paper
• The proteinase-binding reaction of alpha 2M.

  1994cited by this paper
• Immunolocalization of collagenase and TIMP in healing human burn wounds.

  1994cited by this paper
• Cell-matrix interactions modulate interstitial collagenase expression by human keratinocytes actively involved in wound healing.

  1993cited by this paper
• Alpha 2-macroglobulin and pregnancy zone protein. Serum levels, alpha 2-macroglobulin receptors, cellular synthesis and aspects of function in relation to immunology.

  1993cited by this paper
• Stromal fibroblasts synthesize collagenase and stromelysin during long-term tissue remodeling.

  1993cited by this paper
• Wound fluid from chronic leg ulcers contains elevated levels of metalloproteinases MMP-2 and MMP-9.

  1993cited by this paper
• Proteolytic activity in leg ulcer exudate

  1993cited by this paper
• Demonstration of 72-kDa and 92-kDa forms of type IV collagenase in human skin: variable expression in various blistering diseases, induction during re-epithelialization, and decrease by topical glucocorticoids.

  1993cited by this paper
• Matrix metalloproteinases: a review.

  1993cited by this paper
• Alpha 2-macroglobulin and pregnancy zone protein. Serum levels, alpha 2-macroglobulin receptors, cellular synthesis and aspects of function in relation to immunology.

  1993cited by this paper
• Tissue and urokinase plasminogen activators in the environs of venous and ischaemic leg ulcers

  1993cited by this paper
• Collagenase in wound healing: effect of wound age and type.

  1992cited by this paper
• Localization of cleavage sites for human fibroblast collagenase in the bait region of five mammalian alpha-macroglobulins.

  1992cited by this paper
• Characterization of biologic properties of wound fluid collected during early stages of wound healing.

  1992cited by this paper
• Degradation of Fibronectin and Vitronectin and Vitronectin in Chronic Wound Fluid: Analysis by Cell Blotting, Immunoblotting, and Cell Adhesion Assays

  1992cited by this paper
• α2“Macroglobulin, a multifunctional binding protein with targeting characteristics

  1992cited by this paper
• Degradation of fibronectin and vitronectin in chronic wound fluid: analysis by cell blotting, immunoblotting, and cell adhesion assays.

  1992cited by this paper
• The matrix‐degrading metalloproteinases

  1992cited by this paper
• Matrix metalloproteinases in periodontal tissue remodelling.

  1992cited by this paper
• Structure of alpha 2-macroglobulin-protease complexes. Methylamine competition shows that proteases bridge two disulfide-bonded half-molecules.

  1992cited by this paper
• Matrix metalloproteinases and their inhibitors in connective tissue remodeling

  1991cited by this paper
• Collagenase production at the border of granulation tissue in a healing wound: macrophage and mesenchymal collagenase production in vivo.

  1991cited by this paper
• Extracellular Matrix Degradation

  1991cited by this paper
• Fibronectin profiles in normal and chronic wound fluid.

  1990cited by this paper
• Gelatinase (type IV collagenase) immunolocalization in cells and tissues: use of an antiserum to rabbit bone gelatinase that identifies high and low Mr forms.

  1989cited by this paper
• Interaction of human rheumatoid synovial collagenase (matrix metalloproteinase 1) and stromelysin (matrix metalloproteinase 3) with human alpha 2-macroglobulin and chicken ovostatin. Binding kinetics and identification of matrix metalloproteinase cleavage sites.

  1989cited by this paper
• Human fibroblast collagenase-alpha-macroglobulin interactions. Localization of cleavage sites in the bait regions of five mammalian alpha-macroglobulins.

  1989cited by this paper
• Two peptides related to platelet-derived growth factor are present in human wound fluid.

  1989cited by this paper
• Purification and characterization of two related but distinct metalloproteinase inhibitors secreted by bovine aortic endothelial cells.

  1989cited by this paper
• Plasmin-like proteinase associated with high molecular weight complexes in blister fluid of bullous pemphigoid.

  1989cited by this paper
• Epidermal plasminogen activator is abnormal in cutaneous lesions.

  1988cited by this paper
• Polypeptide composition of human macrophage gelatinase.

  1987cited by this paper
• Paired serum and synovial fluid values of alpha 2-macroglobulin and TIMP in rheumatoid arthritis.

  1987cited by this paper
• PAIRED SERUM AND SYNOVIAL FLUID VALUES OF α2-MACROGLOBULIN AND TIMP IN RHEUMATOID ARTHRITIS

  1987cited by this paper
• Preferential binding of collagenase to α2‐macroglobulin in the presence of the tissue inhibitor of metalloproteinases

  1986cited by this paper
• Biochemical and immunological characterization of the secreted forms of human neutrophil gelatinase.

  1985cited by this paper
• The in vitro response of fibroblasts to the fluid that accumulates under a vapor-permeable membrane.

  1985cited by this paper
• Neutral protease, collagenase and elastase activities in synovial fluids from arthritic patients

  1984cited by this paper
• Collagenase is a major gene product of induced rabbit synovial fibroblasts

  1984cited by this paper
• Covalent thrombin-alpha 2-macroglobulin complexes. Evidence for bivalent cross-linking of inhibitor chains by a single enzyme molecule.

  1984cited by this paper
• Human skin fibroblast collagenase inhibitor. Purification and biochemical characterization.

  1983cited by this paper
• Demonstration of collagenase and elastase activities in the blister fluids from bullous skin diseases. Comparison between dermatitis herpetiformis and bullous pemphigoid.

  1983cited by this paper
• Human skin fibroblast procollagenase: mechanisms of activation by organomercurials and trypsin.

  1983cited by this paper
• The interaction of alpha2-macroglobulin with proteinases. Binding and inhibition of mammalian collagenases and other metal proteinases.

  1974cited by this paper
• Evidence for the presence of a complex of collagenase with alpha2-macroglobulin in human rheumatoid synovial fluid: a possible regulatory mechanism of collagenase activity in vivo.

  1973cited by this paper
• Inhibition of human skin collagenase by human serum.

  1970cited by this paper
• Collagenases in human synovial fluid.

  1969cited by this paper
• Collagenolytic activity during mammalian wound repair.

  1967cited by this paper

• Comparison of dermal and eschar fibroblasts in full skin equivalents

  2025cites this paper
• Targeting matrix metalloproteases in diabetic wound healing

  2023cites this paper
• Wound fluid sampling methods for proteomic studies: A scoping review

  2022cites this paper
• Protease levels are significantly altered in pediatric burn wounds.

  2020cites this paper
• Shedding of proangiogenic microvesicles from hypertrophic scar myofibroblasts

  2020cites this paper
• Anti-inflammatory Effect of Juniperus procera Extract in Rats Exposed to Streptozotocin Toxicity

  2019cites this paper
• α‐2‐Macroglobulin induces the shedding of microvesicles from cutaneous wound myofibroblasts

  2018cites this paper
• Valoración clínica de la colagenasa clostridium histolyticum para el tratamiento de la enfermedad de dupuytren a corto y medio plazo

  2018influential citation
• The effect of biological sealants and adhesive treatments on matrix metalloproteinase expression during renal injury healing

  2017cites this paper
• Adverse Effects of Collagenase in the Treatment of Dupuytren Disease: A Systematic Review

  2017cites this paper
• Protease activity as a prognostic factor for wound healing in venous leg ulcers.

  2017cites this paper
• Dupuytren and Collagenase : Are they really as Simple as they Seem ?

  2016cites this paper
• Elevated levels of matrix metalloproteinases and chronic wound healing : an updated review of clinical evidence matrix metalloproteinase ; chronic wound ; wound healing

  2016cites this paper
• Table 1. Summary of chronic wound fluid protein analyses

  2016cites this paper
• Elevated levels of matrix metalloproteinases and chronic wound healing: an updated review of clinical evidence.

  2016cites this paper
• Enhancement of vasculogenesis in mouse embryonic stem cells by alpha 2 macroglobulin activating the LRP1 signaling pathway

  2015cites this paper
• Omics profiles in chronic venous ulcer wound fluid: innovative applications for translational medicine

  2014influential citation
• α2-Macroglobulin Enhances Vasculogenesis/Angiogenesis of Mouse Embryonic Stem Cells by Stimulation of Nitric Oxide Generation and Induction of Fibroblast Growth Factor-2 Expression

  2013cites this paper
• Mutations in the Catalytic Domain of Human Matrix Metalloproteinase-1 (MMP-1) That Allow for Regulated Activity through the Use of Ca2+

  2013cites this paper
• Wound Fluid in Diabetic Foot Ulceration

  2013cites this paper
• Effects of T-2 toxin and selenium on chondrocyte expression of matrix metalloproteinases (MMP-1, MMP-13), α2-macroglobulin (α2M) and TIMPs.

  2011cites this paper
• Matrix Metalloproteinases and Their Inhibitors in Turnover and Degradation of Extracellular Matrix

  2011cites this paper
• Differential proteomic analysis distinguishes tissue repair biomarker signatures in wound exudates obtained from normal healing and chronic wounds.

  2010cites this paper
• Mouse models of MMP and TIMP function.

  2010cites this paper
• Thy-1-Integrin αvβ5 Interactions Inhibit Lung Fibroblast Contraction-induced Latent Transforming Growth Factor-β1 Activation and Myofibroblast Differentiation*

  2010cites this paper
• A Clinical Review of Infected Wound Treatment with Vacuum Assisted Closure® (V.A.C.®) Therapy: Experience and Case Series

  2009cites this paper
• Activation and silencing of matrix metalloproteinases.

  2008cites this paper
• Myocardial matrix remodeling and the matrix metalloproteinases: influence on cardiac form and function.

  2007cites this paper
• and osteoarthritis arthritis, from patients with joint injury, inflammatory MMP protein and activity levels in synovial fluid

  2006cites this paper
• MMP protein and activity levels in synovial fluid from patients with joint injury, inflammatory arthritis, and osteoarthritis

  2005cites this paper
• Pathophysiology of chronic nonhealing wounds.

  2005cites this paper
• MPP protein and activity levels in synovial fluid from patients with joint injury , inflammatory arthritis , and

  2005cites this paper
• Extracellular proteolysis and venous leg ulcer

  2004cites this paper
• Mitosis increases levels of secretory leukocyte protease inhibitor in keratinocytes.

  2004cites this paper
• The role of collagenases in atherosclerotic plaque instability

  2004cites this paper
• Extracellular matrix metabolites as potential biomarkers of disease activity in wound fluid: lessons learned from other inflammatory diseases?

  2004cites this paper
• Culture confluence regulates gene expression of normal human keratinocytes

  2004cites this paper
• EXTENDED REPORT Matrix metalloproteinases-3, -8, -9 as markers of disease activity and joint damage progression in early rheumatoid arthritis

  2003cites this paper
• Topical negative pressure therapy in wound healing : a research tool to study neutrophil-mediated wound pathophysiology in acute dermal wounds

  2003cites this paper
• The influence of α1‐acid glycoprotein on collagenase‐3 activity in early rheumatoid arthritis

  2003cites this paper
• Matrix metalloproteinases-3, -8, -9 as markers of disease activity and joint damage progression in early rheumatoid arthritis

  2003cites this paper
• Active MMPs captured by alpha 2 macroglobulin as a marker of disease activity in rheumatoid arthritis.

  2003cites this paper
• The influence of alpha1-acid glycoprotein on collagenase-3 activity in early rheumatoid arthritis.

  2003cites this paper
• Selective processing of a follicular matrix metalloproteinase-2 isoform by human oviducal fluid.

  2003cites this paper
• Inflammation. 2: Its role in the healing of chronic wounds.

  2002cites this paper
• Bovine Follicular Fluid and Serum Share a Unique Isoform of Matrix Metalloproteinase-2 That Is Degraded by the Oviductal Fluid1

  2001cites this paper
• Differential effects of acute and chronic wound fluids on urokinase‐type plasminogen activator, urokinase‐type plasminogen activator receptor, and tissue‐type plasminogen activator in cultured human keratinocytes and fibroblasts

  2001cites this paper
• The proteolytic environment of chronic wounds

  1999cites this paper
• Growth factors secreted by fibroblasts: role in healing diabetic foot ulcers

  1999cites this paper
• Fibrogenesis and fibrolysis in collagenous colitis. Patterns of procollagen types I and IV, matrix-metalloproteinase-1 and -13, and TIMP-1 gene expression.

  1999cites this paper
• Different expression of the α2-macroglobulin receptor/low-density lipoprotein receptor-related protein in human keratinocytes and fibroblasts

  1998cites this paper