Intermolecular hydroaminoalkylation of alkenes and dienes using a titanium mono(formamidinate) catalyst.

An easily accessible formamidinate ligand-bearing titanium complex initially synthesized by Eisen et al. is used as catalyst for intermolecular hydroaminoalkylation reactions of unactivated, sterically demanding 1,1- and 1,2-disubstituted alkenes and styrenes with secondary amines. The corresponding reactions, which have never been achieved with titanium catalysts before, take place with excellent regioselectivity (up to 99 : 1) and in addition, corresponding reactions of 1,3-butadienes with N-methylbenzylamine are also described for the first time.

• Publication year

  2015

• Venue

  Dalton Transactions

• Publication date

  2015-07-02

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1039/c4dt03916ePMID 25679294
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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