Rapamycin prevents cerebral stroke by modulating apoptosis and autophagy in penumbra in rats

Meiling Wu,Huadan Zhang,Jiejing Kai,Feng Zhu,Jing-Yin Dong,Ziwei Xu,M. Wong,L. Zeng

Published 2017 in Annals of Clinical and Translational Neurology

ABSTRACT

Whether activation or inhibition of the mTOR pathway is beneficial to ischemic injury remains controversial. It may result from the different reaction of ischemic penumbra and core to modulation of mTOR pathway after cerebral ischemia–reperfusion injury in rats.

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