Homozygous loss of the p15INK4B gene (and not the p16INK4 gene) during tumor progression in a sporadic melanoma patient.

No abstract is available for this paper.

• Publication year

  1995

• Venue

  Cancer Research

• Publication date

  1995-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  PMID 7585628
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• 5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers

  1995cited by this paper
• Germline p16INK4A mutation and protein dysfunction in a family with inherited melanoma.

  1995cited by this paper
• Loss of expression of the p16/cyclin-dependent kinase inhibitor 2 tumor suppressor gene in melanocytic lesions correlates with invasive stage of tumor progression.

  1995cited by this paper
• High frequency of chromosome 9p allelic loss and CDKN2 tumor suppressor gene alterations in squamous cell carcinoma of the bladder.

  1995cited by this paper
• Chromosome 9p deletions in cutaneous malignant melanoma tumors: the minimal deleted region involves markers outside the p16 (CDKN2) gene.

  1995cited by this paper
• Complex structure and regulation of the P16 (MTS1) locus.

  1995cited by this paper
• Genetic evidence in melanoma and bladder cancers that p16 and p53 function in separate pathways of tumor suppression.

  1995cited by this paper
• A novel p16INK4A transcript.

  1995cited by this paper
• Construction of a 2.8-megabase yeast artificial chromosome contig and cloning of the human methylthioadenosine phosphorylase gene from the tumor suppressor region on 9p21.

  1995cited by this paper
• Mutations associated with familial melanoma impair p16INK4 function

  1995cited by this paper
• Homozygotes for CDKN2 (p16) germline mutation in Dutch familial melanoma kindreds

  1995cited by this paper
• Mutations of the CDKN2/p16INK4 gene in Australian melanoma kindreds.

  1995cited by this paper
• A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma

  1995cited by this paper
• Genomic structure, expression and mutational analysis of the P15 (MTS2) gene.

  1995cited by this paper
• A cell cycle regulator potentially involved in genesis of many tumor types.

  1994influential reference
• Mapping a putative tumor suppressor gene on chromosome 9 bands p21-p22 with microdissection probes.

  1994cited by this paper
• Transcriptional repression of the D-type cyclin-dependent kinase inhibitor p16 by the retinoblastoma susceptibility gene product pRb.

  1994cited by this paper
• Germline p16 mutations in familial melanoma

  1994cited by this paper
• p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest.

  1994cited by this paper
• Differential expression and cell cycle regulation of the cyclin-dependent kinase 4 inhibitor p16Ink4.

  1994cited by this paper
• Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers

  1994cited by this paper
• Deletion of p16 and p15 genes in brain tumors.

  1994cited by this paper
• Rarity of somatic and germline mutations of the cyclin-dependent kinase 4 inhibitor gene, CDK4I, in melanoma.

  1994cited by this paper
• A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

  1993influential reference
• Homozygous deletions within human chromosome band 9p21 in melanoma.

  1992cited by this paper
• Genetic and physical map of the interferon region on chromosome 9p.

  1992cited by this paper
• Genetics of melanoma.

  1990cited by this paper
• Tumor progression stage: specific losses of heterozygosity.

  1989cited by this paper
• Chromosomal evolution in the progression and metastasis of human malignant melanoma. A multiple lesion study.

  1989cited by this paper
• Possible involvement of the chromosome region 10q24----q26 in early stages of melanocytic neoplasia.

  1988cited by this paper
• Cytogenetic analysis of melanocytes from premalignant nevi and melanomas.

  1988cited by this paper
• Loss of heterozygosity at autosomal and X-linked loci during tumor progression in a patient with melanoma.

  1987cited by this paper
• Transforming ras genes from human melanoma: a manifestation of tumour heterogeneity?

  1984cited by this paper
• Mutation and cancer: statistical study of retinoblastoma.

  1971cited by this paper

• Small round cell sarcomas

  2022cites this paper
• p15 Expression Differentiates Nevus from Melanoma.

  2016cites this paper
• CDKN2B Loss Promotes Progression from Benign Melanocytic Nevus to Melanoma.

  2015cites this paper
• Four Generations of Sequencing- Is it ready for the Clinic Yet?

  2014cites this paper
• Atlas of Genetics and Cytogenetics in Oncology and Haematology

  2014cites this paper
• Genetic and Molecular Pathology of Melanoma

  2014cites this paper
• Melanocytes and Melanoma Etiology

  2014cites this paper
• Cellular and molecular evidence for malignancy-inhibitory functions of p15RS

  2012cites this paper
• Next‐generation sequencing: ready for the clinics?

  2012cites this paper
• Differentiating rectal carcinoma by an immunohistological analysis of carcinomas of pelvic organs based on the NCBI Literature Survey and the Human Protein Atlas database

  2012cites this paper
• [Genetic predisposition in cutaneous melanoma].

  2006cites this paper
• Predisposición genética en el melanoma cutáneo

  2006cites this paper
• Pigmentation, DNA Repair, and Candidate Genes

  2006cites this paper
• Cutaneous melanoma susceptibility and progression genes.

  2005cites this paper
• Genetics, prevention and screening for melanoma.

  2005cites this paper
• Prevalence of 9p21 deletions in UK melanoma families

  2005cites this paper
• Measurement of relative copy number of CDKN2A/ARF and CDKN2B in bladder cancer by real-time quantitative PCR and multiplex ligation-dependent probe amplification.

  2004cites this paper
• Pesquisa de mutações no gene CDKN2A em pacientes com critérios clínicos de melanoma hereditário.

  2004cites this paper
• The Rgr Oncogene Induces Tumorigenesis in Transgenic Mice

  2004cites this paper
• The genetics of malignant melanoma: lessons from mouse and man

  2003cites this paper
• Hypermethylation of the P15INK4b and P16INK4a in agnogenic myeloid metaplasia (AMM) and AMM in leukaemic transformation

  2002cites this paper
• Preferential loss of maternal 9p alleles in childhood acute lymphoblastic leukemia.

  2002cites this paper
• Quantitative real-time PCR does not show selective targeting of p14ARF but concomitant inactivation of both p16INK4A and p14ARF in 105 human primary gliomas

  2001cites this paper
• Malignant melanoma: An update

  2001cites this paper
• Malignant melanoma.

  2001cites this paper
• Gene transfer by adenovirus vectors

  2001cites this paper
• Expression of p15 and p15.5 products in neuroendocrine lung tumours: relationship with p15INK4b methylation status

  2001cites this paper
• A single nucleotide polymorphism in the 3′untranslated region of the CDKN2A gene is common in sporadic primary melanomas but mutations in the CDKN2B, CDKN2C, CDK4 and p53 genes are rare

  2001cites this paper
• Limited overlapping roles of P15INK4b and P18INK4c cell cycle inhibitors in proliferation and tumorigenesis

  2000cites this paper
• Large deletions of chromosome 9p in cutaneous malignant melanoma identify patients with a high risk of developing metastases

  2000cites this paper
• Tumor suppressor INK4: Refinement of p16INK4A structure and determination of p15INK4B structure by comparative modeling and NMR data

  2000cites this paper
• Analysis of G1/S checkpoint regulators in metastatic melanoma

  2000cites this paper
• Melanoma genetics: an update with focus on the CDKN2A(p16)/ARF tumor suppressors.

  2000cites this paper
• Intermediate dose recombinant interferon‐α as second‐line treatment for patients with recurrent cutaneous melanoma who were pretreated with low dose interferon

  2000cites this paper
• Estudi clinicopatòlogic i genètic del melanoma maligne i de la síndrome del nevus displàstic.

  2000cites this paper
• Monoclonal Antibody Probes for p21WAF1/CIP1 and the INK4 Family of Cyclin-Dependent Kinase Inhibitors

  2000cites this paper
• Analysis of tumor cell evolution in a melanoma: evidence of mutational and selective pressure for loss of p16ink4 and for microsatellite instability.

  2000cites this paper
• determination of p 15 INK 4 B structure by comparative modeling and Tumor suppressor INK 4 : refinement of p 16 INK 4 A structure and service

  2000cites this paper
• Positive tetracycline control of expression of p15INK4B from an Epstein-Barr autonomous plasmid in a human melanoma cell line.

  2000cites this paper
• Aberrant methylation of p16INK4a and deletion of p15INK4b are frequent events in human esophageal cancer in Linxian, China.

  1999cites this paper
• Induction of melanoma in TPras transgenic mice.

  1999cites this paper
• Involvement of the Ink4a gene (p16 and p19arf) in murine tumorigenesis.

  1999cites this paper
• Multiple abnormalities of the p16INK4a-pRb regulatory pathway in cultured melanoma cells.

  1999cites this paper
• Hypermethylation of the cell cycle inhibitor p15INK4b 3′-untranslated region interferes with its transcriptional regulation in primary lymphomas

  1999cites this paper
• Abnormal cell cycle regulation in malignancy.

  1999cites this paper
• The INK4A/ARF locus and its two gene products.

  1999cites this paper
• Molecular pathology of malignant melanoma.

  1998cites this paper
• Retention of the CDKN2A locus and low frequency of point mutations in primary and metastasic cutaneous malignant melanoma

  1998cites this paper
• Molecular biology of human melanoma development and progression

  1998cites this paper
• An increased frequency of numerical chromosomal abnormalities and 1p36 deletions in isolated cells from paraffin sections of malignant melanomas by means of interphase cytogenetics.

  1998cites this paper
• Virtually 100% of melanoma cell lines harbor alterations at the DNA level within CDKN2A, CDKN2B, or one of their downstream targets

  1998cites this paper
• The INK4a/ARF tumor suppressor: one gene--two products--two pathways.

  1998cites this paper
• Homozygous deletion of the p16INK4a and the p15INK4b tumour suppressor genes in a subset of human sporadic cutaneous malignant melanoma

  1998cites this paper
• Mutations of p16 and p15 tumor suppressor genes and replication errors contribute independently to the pathogenesis of sporadic malignant melanoma

  1998cites this paper
• The p16INK4a/CDKN2A tumor suppressor and its relatives.

  1998cites this paper
• Molecular pathology of melanoma

  1997cites this paper
• Hemizygous or homozygous deletion of the chromosomal region containing the p16INK4a gene is associated with amplification of the EGF receptor gene in glioblastomas

  1997cites this paper
• Differential expression of p16INK4a and p16beta transcripts in B-lymphoblastoid cells from members of hereditary melanoma families without CDKN2A exon mutations.

  1997cites this paper
• Analysis of the CDKN2A, CDKN2B and CDK4 genes in 48 Australian melanoma kindreds

  1997cites this paper
• Cooperative effects of INK4a and ras in melanoma susceptibility in vivo.

  1997cites this paper
• p16/CDKN2 and CDK4 gene mutations in sporadic melanoma development and progression

  1997cites this paper
• Screening of germline mutations in the CDKN2A and CDKN2B genes in Swedish families with hereditary cutaneous melanoma.

  1997cites this paper
• Frequent and selective methylation of p15 and deletion of both p15 and p16 in T-cell acute lymphoblastic leukemia.

  1997cites this paper
• CDKN2 (MTS1/p16INK4A) gene alterations in hematological malignancies.

  1997cites this paper
• - INK4A/MTS1/CDK41/CDKN2, INK4B/MTS2, INK4C, INK4D

  1997cites this paper
• Molecular pathology of melanoma

  1997cites this paper
• Inactivation of the cyclin-dependent kinase inhibitor p15INK4b by deletion and de novo methylation with independence of p16INK4a alterations in murine primary T-cell lymphomas

  1997cites this paper
• Analysis of the p16INK4A, p15INK4B and p18INK4C genes in multiple myeloma

  1997cites this paper
• Molecular mechanisms controlling human melanoma progression and metastasis.

  1997cites this paper
• Low frequency of p16/CDKN2A methylation in sporadic melanoma: comparative approaches for methylation analysis of primary tumors.

  1997cites this paper
• Loss of heterozygosity at chromosome 9p21 in primary neuroblastomas: evidence for two deleted regions.

  1997cites this paper
• Chromosomal and genetic alterations of 7,12‐ Dimethylbenz[a]anthracene–induced melanoma from TP‐ras transgenic mice

  1997cites this paper
• Homozygous codeletion and differential decreased expression of p15INK4b, p16INK4a-alpha and p16INK4a-beta in mouse lung tumor cells.

  1996cites this paper
• Allelic loss of 9p21 and mutation of the CDKN2/p16 gene develop as early lesions during neoplastic progression in Barrett's esophagus.

  1996cites this paper
• CDKN2 mutations in melanoma.

  1996cites this paper
• Oncogenes and Tumor Suppressor Genes in Cutaneous Malignant Melanoma

  1996cites this paper
• Loss of the p16INK4a and p15INK4b genes, as well as neighboring 9p21 markers, in sporadic melanoma.

  1996cites this paper
• Homozygous deletions of p16INK4 occur frequently in bilharziasis‐associated bladder cancer

  1996cites this paper
• Cancer genetics: Two tracks but one race?

  1996cites this paper
• Clinical implications of cytogenetic abnormalities in melanoma.

  1996cites this paper
• Two tracks but one race? Cancer genetics.

  1996cites this paper
• Lack of mutation in the cyclin-dependent kinase inhibitor, p19INK4d, in tumor-derived cell lines and primary tumors.

  1996cites this paper
• Loss of the pJ 6 INK 4 aand @ 15 INK 4 bGenes , as well as Neighboring 9 p 2 i Markers , in Sporadic Melanoma 1

  year unknowncites this paper