Family history of diabetes and its relationship with insulin secretion and insulin sensitivity in Iraqi immigrants and native Swedes: a population-based cohort study

AbstractAims Middle Eastern immigrants to western countries are at high risk of developing type 2 diabetes. However, the heritability and impact of first-degree family history (FH) of type 2 diabetes on insulin secretion and action have not been adequately described.MethodsCitizens of Malmö, Sweden, aged 30–75 years born in Iraq or Sweden were invited to participate in this population-based study. Insulin secretion (corrected insulin response and oral disposition index) and action (insulin sensitivity index) were assessed by oral glucose tolerance tests.ResultsIn total, 45.7% of Iraqis (616/1348) and 27.4% of native Swedes (201/733) had FH in parent(s), sibling(s) or single parent and sibling, i.e., FH+. Approximately 8% of Iraqis and 0.7% of Swedes had ≥ 3 sibling(s) and parent(s) with diabetes, i.e., FH++. Irrespective of family size, prediabetes and diabetes increased with family burden (FH− 29.4%; FH+ 38.8%; FH++ 61.7%) without significant differences across ethnicities. With increasing level of family burden, insulin secretion rather than insulin action decreased. Individuals with a combination of ≥ 3 siblings and parents with diabetes presented with the lowest levels of insulin secretion.ConclusionsThe Iraqi immigrant population often present with a strong familial burden of type 2 diabetes with the worst glycemic control and highest diabetes risk in individuals with ≥ 3 siblings and parents with diabetes. Our data show that in a population still free from diabetes familial burden influences insulin secretion to a higher degree than insulin action and may be a logical target for intervention.

• Publication year

  2017

• Venue

  Acta Diabetologica

• Publication date

  2017-12-22

• Fields of study

  Medicine

• Identifiers
  DOI 10.1007/s00592-017-1088-5PMID 29274011PMCID 5829110
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Changes in dietary intake following a culturally adapted lifestyle intervention among Iraqi immigrants to Sweden at high risk of type 2 diabetes: a randomised trial

  2017cited by this paper
• Focus on migrants with type 2 diabetes mellitus in European Countries

  2016cited by this paper
• A family history of diabetes determines poorer glycaemic control and younger age of diabetes onset in immigrants from the Middle East compared with native Swedes Glycaemic control in Iraqi immigrants

  2015cited by this paper
• A family history of diabetes determines poorer glycaemic control and younger age of diabetes onset in immigrants from the Middle East compared with native Swedes.

  2015cited by this paper
• Ethnicity is an independent risk indicator when estimating diabetes risk with FINDRISC scores: a cross sectional study comparing immigrants from the Middle East and native Swedes.

  2014influential reference
• Cross-cultural validation of a simple self-report instrument of physical activity in immigrants from the Middle East and native Swedes

  2014cited by this paper
• Ethnic differences in the contribution of insulin action and secretion to type 2 diabetes in immigrants from the Middle East compared to native Swedes.

  2014influential reference
• Genetic and environmental components of family history in type 2 diabetes

  2014cited by this paper
• International Diabetes Federation.

  2013cited by this paper
• The link between family history and risk of type 2 diabetes is not explained by anthropometric, lifestyle or genetic risk factors: the EPIC-InterAct study

  2012cited by this paper
• Genetic predisposition to obesity leads to increased risk of type 2 diabetes

  2011cited by this paper
• Genetics of Obesity: What have we Learned?

  2011cited by this paper
• A family history of diabetes is associated with reduced physical fitness in the Prevalence, Prediction and Prevention of Diabetes (PPP)–Botnia study

  2010cited by this paper
• Clinical risk factors, DNA variants, and the development of type 2 diabetes.

  2009influential reference
• Familial Risks for Type 2 Diabetes in Sweden

  2009cited by this paper
• Genetic Variants of FTO Influence Adiposity, Insulin Sensitivity, Leptin Levels, and Resting Metabolic Rate in the Quebec Family Study

  2008cited by this paper
• Clinical risk factors, DNA variants, and the development of type 2 diabetes.

  2008cited by this paper
• A Common Variant in the FTO Gene Is Associated with Body Mass Index and Predisposes to Childhood and Adult Obesity

  2007cited by this paper
• Genome-Wide Association Analysis Identifies Loci for Type 2 Diabetes and Triglyceride Levels

  2007cited by this paper
• A Caution Regarding Rules of Thumb for Variance Inflation Factors

  2007cited by this paper
• Do immigrants have an increased prevalence of unhealthy behaviours and risk factors for coronary heart disease?

  2005cited by this paper
• Predictors of and longitudinal changes in insulin sensitivity and secretion preceding onset of type 2 diabetes.

  2005cited by this paper
• Talkin’ 'bout My Generation: Environmental Variability and Cohort Effects

  2003cited by this paper
• Accurate assessment of beta-cell function: the hyperbolic correction.

  2002cited by this paper
• Accurate Assessment of β-Cell Function: The Hyperbolic Correction

  2002cited by this paper
• Evaluation of simple indices of insulin sensitivity and insulin secretion for use in epidemiologic studies.

  2000cited by this paper
• Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp.

  1999cited by this paper
• Metabolic Consequences of a Family History of NIDDM (The Botnia Study): Evidence for Sex-Specific Parental Effects

  1996cited by this paper
• Diabetes mellitus. Report of a WHO Study Group.

  1985cited by this paper
• Glucose Tolerance and Insulin Release, A Mathematical Approach: I. Assay of the Beta-cell Response After Oral Glucose Loading

  1976cited by this paper

• Association between the type of family history of diabetes and the risk and age at onset of diabetes in the Japanese general population

  2025influential citation
• Caffeoylquinic Acid Derivatives: Chemical Diversity and Effect on the Oxidative Stress-Related Pathologies

  2024cites this paper
• GWAS in people of Middle Eastern descent reveals a locus protective of kidney function—a cross-sectional study

  2022cites this paper
• Insulin secretion and action with increasing age - A comparison between Middle Eastern immigrants and native Swedes

  2022cites this paper
• Diabetic family history in young Japanese persons with normal glucose tolerance associates with k-means clustering of glucose response to oral glucose load, insulinogenic index and Matsuda index

  2022cites this paper
• Impact of family history of diabetes on blood glucose, lipid levels and perinatal outcomes in pregnant women with gestational diabetes mellitus.

  2021cites this paper
• Effects of family history of diabetes on pancreatic β-cell function and diabetic ketoacidosis in newly diagnosed patients with type 2 diabetes: a cross-sectional study in China

  2021cites this paper
• Development and evaluation of 1-deoxynojirimycin sustained-release delivery system: In vitro and in vivo characterization studies.

  2021cites this paper
• Associations between both legacy and alternative per- and polyfluoroalkyl substances and glucose-homeostasis: The Isomers of C8 health project in China.

  2021cites this paper
• The prevalence and predictors of pre-diabetes and diabetes among adults 40–70 years in Kharameh cohort study: A population-based study in Fars province, south of Iran

  2021cites this paper
• Cultural Food Habits as a Social Factor of Health Among Immigrants in New Haven, Connecticut: A Focused Ethnographic Study

  2020cites this paper
• Adult‐onset diabetes in Middle Eastern immigrants to Sweden: Novel subgroups and diabetic complications—The All New Diabetes in Scania cohort diabetic complications and ethnicity

  2020cites this paper
• Family history of diabetes is associated with diabetic foot complications in type 2 diabetes

  2020cites this paper
• Use of Chlorogenic Acid against Diabetes Mellitus and Its Complications

  2020cites this paper
• Family history of diabetes in both parents is strongly associated with impaired residual β‐cell function in Japanese type 2 diabetes patients

  2019cites this paper
• Clinical phenotyping of newly diagnosed type 2 diabetes in Yemen

  2018cites this paper