Pancreatic beta-cell damage mediated by beta-cell production of interleukin-1. A novel mechanism for virus-induced diabetes.

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Journal of Biological Chemistry

• Publication date

  Unknown publication date

• Fields of study

  Medicine

• Identifiers
  PMID 11108714
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Double-stranded RNA Inhibits β-Cell Function and Induces Islet Damage by Stimulating β-Cell Production of Nitric Oxide*

  1999cited by this paper
• Tumor necrosis factor-alpha-activated cell death pathways in NIT-1 insulinoma cells and primary pancreatic beta cells.

  1999cited by this paper
• Double-stranded RNA-induced inducible nitric-oxide synthase expression and interleukin-1 release by murine macrophages requires NF-kappaB activation.

  1998cited by this paper
• IL-1 produced and released endogenously within human islets inhibits beta cell function.

  1998cited by this paper
• Potential role of resident islet macrophage activation in the initiation of autoimmune diabetes.

  1998cited by this paper
• Diabetes induced by Coxsackie virus: Initiation by bystander damage and not molecular mimicry

  1998cited by this paper
• Pathogenesis and treatment of virus-induced autoimmune diabetes: novel insights gained from the RIP-LCMV transgenic mouse model.

  1997cited by this paper
• Possible role of macrophage-derived soluble mediators in the pathogenesis of encephalomyocarditis virus-induced diabetes in mice

  1997cited by this paper
• Insulin-dependent diabetes mellitus: the hypothesis of molecular mimicry between islet cell antigens and microorganisms.

  1997cited by this paper
• A Model for the Double-stranded RNA (dsRNA)-dependent Dimerization and Activation of the dsRNA-activated Protein Kinase PKR*

  1997cited by this paper
• The Double-Stranded RNA-Dependent Protein Kinase PKR: Structure and Function

  1997cited by this paper
• Nitric oxide and viral infection: NO antiviral activity against a flavivirus in vitro, and evidence for contribution to pathogenesis in experimental infection in vivo.

  1996cited by this paper
• When two strands are better than one: the mediators and modulators of the cellular responses to double-stranded RNA.

  1996cited by this paper
• The role of interleukin-1 in the pathogenesis of IDDM

  1996cited by this paper
• Nitric Oxide Regulates Interleukin 1 Bioactivity Released from Murine Macrophages*

  1996cited by this paper
• Tyrosine kinase inhibitors prevent cytokine-induced expression of iNOS and COX-2 by human islets.

  1996cited by this paper
• The eIF‐2α kinases and the control of protein synthesis 1

  1996cited by this paper
• Virus-induced autoimmune disease

  1996cited by this paper
• Using Transgenic Mouse Models to Dissect the Pathogenesis of Virus‐Induced Autoimmune Disorders of the Islets of Langerhans and the Central Nervous System

  1996cited by this paper
• A new look at viruses in type 1 diabetes

  1995cited by this paper
• Intraislet release of interleukin 1 inhibits beta cell function by inducing beta cell expression of inducible nitric oxide synthase

  1995cited by this paper
• Inhibition of vaccinia virus DNA replication by inducible expression of nitric oxide synthase.

  1995cited by this paper
• Insulin-dependent diabetes mellitus as an autoimmune disease.

  1994cited by this paper
• Structure and mechanism of interleukin-1 beta converting enzyme.

  1994cited by this paper
• Reversibility of interleukin-1 beta-induced islet destruction and dysfunction by the inhibition of nitric oxide synthase.

  1994cited by this paper
• Cellular immunity to a determinant common to glutamate decarboxylase and coxsackie virus in insulin-dependent diabetes.

  1994cited by this paper
• Inhibition of viral replication by interferon-gamma-induced nitric oxide synthase.

  1993cited by this paper
• Nitric oxide mediates cytokine-induced inhibition of insulin secretion by human islets of Langerhans.

  1993cited by this paper
• The Antiviral Effects of the Interferons and Their Inhibition

  1992cited by this paper
• Poly I:C Induces Development of Diabetes Mellitus in BB Rat

  1992cited by this paper
• Poly I:C Accelerates Development of Diabetes Mellitus in Diabetes-Prone BB Rat

  1992cited by this paper
• Interleukin 1 receptor antagonist. A new member of the interleukin 1 family.

  1991cited by this paper
• Activation of intraislet lymphoid cells causes destruction of islet cells.

  1991cited by this paper
• Interleukin 1 inhibits insulin secretion from isolated rat pancreatic islets by a process that requires gene transcription and mRNA translation.

  1990cited by this paper
• Interleukin 3-dependent and -independent mast cells stimulated with IgE and antigen express multiple cytokines

  1989cited by this paper
• A new in vitro model for the study of pancreatic A and B cells.

  1985cited by this paper
• Concepts in Viral Pathogenesis

  1984cited by this paper
• Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids.

  1982cited by this paper
• Virus-induced diabetes mellitus. XV. Beta cell damage and insulin- dependent hyperglycemia in mice infected with coxsackie virus B4

  1978cited by this paper
• Insulin Immunoassay by Back-Titration; Some Characteristics of the Technic and the Insulin Precipitant Action of Alcohol

  1971cited by this paper
• Pathologic Anatomy of the Pancreas in Juvenile Diabetes Mellitus

  1965cited by this paper

• Heme-Derived Metabolic Signals Dictate Immune Responses

  2020cites this paper
• Pharmacological actions and therapeutic potentials of bilirubin in islet transplantation for the treatment of diabetes.

  2019cites this paper
• The Role of MicroRNAs in Diabetes-Related Oxidative Stress

  2019cites this paper
• Neuroinflammation and central PI3K/Akt/mTOR signal pathway contribute to bone cancer pain

  2019cites this paper
• RETRACTED ARTICLE: Involvement of pro-inflammatory cytokines in diabetic neuropathic pain via central PI3K/Akt/mTOR signal pathway

  2019cites this paper
• Participation of pro-inflammatory cytokines in neuropathic pain evoked by chemotherapeutic oxaliplatin via central GABAergic pathway

  2018cites this paper
• Dual Role of Nitric Oxide in Regulating the Response of β Cells to DNA Damage

  2017cites this paper
• Contribution of Pro-inflammatory Cytokine Signaling within Midbrain Periaqueductal Gray to Pain Sensitivity in Parkinson’s Disease via GABAergic Pathway

  2016cites this paper
• Highly efficient adenoviral transduction of pancreatic islets using a microfluidic device.

  2016cites this paper
• Osteoprotegerin Regulates Pancreatic β-Cell Homeostasis upon Microbial Invasion

  2016cites this paper
• IL-10 and IL-1β Mediate Neuropathic-Pain Like Behavior in the Ventrolateral Orbital Cortex

  2015influential citation
• Islet amyloid polypeptide aggregation is a local trigger for pancreatic islet inflammation

  2014cites this paper
• Resident Macrophages Mediate Islet Amyloid Polypeptide–Induced Islet IL-1β Production and β-Cell Dysfunction

  2014cites this paper
• Metabolic syndrome and insulin resistance: underlying causes and modification by exercise training.

  2013cites this paper
• A critical role for interleukin-1β in the progression of autoimmune diseases.

  2013cites this paper
• Cytokine and Chemokine Production by Human Pancreatic Islets Upon Enterovirus Infection

  2012cites this paper
• Toll-like receptors, the NLRP3 inflammasome, and interleukin-1β in the development and progression of type 1 diabetes

  2012cites this paper
• Neutralizing Interleukin-1β (IL-1β) Induces β-Cell Survival by Maintaining PDX1 Protein Nuclear Localization*

  2011cites this paper
• Interleukin-targeted therapy for metabolic syndrome and type 2 diabetes.

  2011cites this paper
• Interleukin-1 beta targeted therapy for type 2 diabetes

  2009cites this paper
• Cytokines and beta-cell biology: from concept to clinical translation.

  2008cites this paper
• Insulitis in type 2 diabetes

  2008cites this paper
• Interleukin-1β of Red nucleus involved in the development of allodynia in spared nerve injury rats

  2008cites this paper
• Macrophages, cytokines and beta-cell death in Type 2 diabetes.

  2008cites this paper
• Astragalus polysaccharides: an effective treatment for diabetes prevention in NOD mice.

  2008cites this paper
• Increased interleukin (IL)-1beta messenger ribonucleic acid expression in beta -cells of individuals with type 2 diabetes and regulation of IL-1beta in human islets by glucose and autostimulation.

  2008cites this paper
• Therapeutic Applications of Bilirubin and Biliverdin in Transplantation

  2007cites this paper
• Induction of CXCL1 by extracellular matrix and autocrine enhancement by interleukin-1 in rat pancreatic beta-cells.

  2007cites this paper
• Selective induction of inducible nitric oxide synthase in pancreatic islet of rat after an intravenous glucose or intralipid challenge.

  2006cites this paper
• Bilirubin can induce tolerance to islet allografts.

  2006cites this paper
• Aspects of the molecular and functional genetics in T1DM: a study of selected candidate genes.

  2006cites this paper
• Low Concentration of Interleukin-1β Induces FLICE-Inhibitory Protein–Mediated β-Cell Proliferation in Human Pancreatic Islets

  2006cites this paper
• Low concentration of interleukin-1beta induces FLICE-inhibitory protein-mediated beta-cell proliferation in human pancreatic islets.

  2006cites this paper
• MHC-Mismatched Islet Allografts Are Vulnerable to Autoimmune Recognition In Vivo1

  2005cites this paper
• NON-MHC genes in type 1 diabetes. Family-based association studies and functional studies of disease-associated polymorphisms.

  2005cites this paper
• Association between Endocrine Pancreas and Ductal System. More than an Epiphenomenon of Endocrine Differentiation and Development?

  2005cites this paper
• dsRNA formed as an intermediate during Coxsackievirus infection does not induce NO production in a beta-cell line with or without addition of IFN-gamma.

  2005cites this paper
• Encephalomyocarditis Virus Induces PKR-Independent Mitogen-Activated Protein Kinase Activation in Macrophages

  2005cites this paper
• Intrathecal interleukin-1beta administration induces thermal hyperalgesia by activating inducible nitric oxide synthase expression in the rat spinal cord.

  2004cites this paper
• Response of human islets to isolation stress and the effect of antioxidant treatment.

  2004cites this paper
• Retrovirally Transferred Genes Inhibit Apoptosis in an Insulin-Secreting Cell Line: Implications for Islet Transplantation

  2004cites this paper
• Human pancreatic duct cells can produce tumour necrosis factor-α that damages neighbouring beta cells and activates dendritic cells

  2004cites this paper
• Changes in expression of IL-1β influenced proteins in transplanted islets during development of diabetes in diabetes-prone BB rats

  2004cites this paper
• Immunoregulatory Role of Nitric Oxide in Kilham Rat Virus-Induced Autoimmune Diabetes in DR-BB Rats1

  2004cites this paper
• Leptin modulates beta cell expression of IL-1 receptor antagonist and release of IL-1beta in human islets.

  2004cites this paper
• Intratracheal double-stranded RNA plus interferon-gamma: a model for analysis of the acute phase response to respiratory viral infections.

  2004cites this paper
• Role of caspases in the regulation of apoptotic pancreatic islet beta‐cells death

  2004cites this paper
• Nuclear factor-kappaB translocation mediates double-stranded ribonucleic acid-induced NIT-1 beta-cell apoptosis and up-regulates caspase-12 and tumor necrosis factor receptor-associated ligand (TRAIL).

  2003cites this paper
• Inflammatory mediators and islet β-cell failure: a link between type 1 and type 2 diabetes

  2003cites this paper
• The genetics of adiponectin

  2003cites this paper
• The role of cytokines as effectors of tissue destruction in autoimmunity.

  2003cites this paper
• Effector Lymphocytes in Islet Cell Autoimmunity

  2003influential citation
• Acute pancreatitis, expression of inducible nitric oxide synthase and defective insulin secretion

  2003cites this paper
• Glucose-induced β cell production of IL-1β contributes to glucotoxicity in human pancreatic islets.

  2002cites this paper
• Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets.

  2002cites this paper
• Double-stranded RNA cooperates with interferon-gamma and IL-1 beta to induce both chemokine expression and nuclear factor-kappa B-dependent apoptosis in pancreatic beta-cells: potential mechanisms for viral-induced insulitis and beta-cell death in type 1 diabetes mellitus.

  2002cites this paper
• Role of proinflammatory cytokines in the impaired lacrimation associated with autoimmune xerophthalmia.

  2002cites this paper
• Role of Interferon Regulatory Factor-1 in Double-stranded RNA-induced iNOS Expression by Mouse Islets*

  2002cites this paper