The structure and mechanism of activation of the first component of complement.

No abstract is available for this paper.

• Publication year

  1975

• Venue

  Contemporary topics in molecular immunology

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1007/978-1-4615-8930-3_1PMID 1104255
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Chemical analysis and electron microscopy studies of human C1q prepared by different methods

  1975cited by this paper
• The NH2-terminal sequences of a subunit of the first component of human complement, Cls, and its activated form Cls¯

  1975cited by this paper
• Characterization of a plasmin-digest fragment of rabbit immunoglobulin gamma that binds antigen and complement.

  1975cited by this paper
• Fixation of the first component of complement by immune complexes: effect of reduction and fragmentation of antibody.

  1975cited by this paper
• The NH-2-terminal sequences of a subunit of the first component of human complement, C1s, and its activated form, C1s.

  1975cited by this paper
• A collagen-like amino acid sequence in a polypeptide chain of human C1q (a subcomponent of the first component of complement).

  1974cited by this paper
• A simple method for the isolation of the subcomponents of the first component of complement by affinity chromatography.

  1974cited by this paper
• Enzymatic digestion of the first component of human complement (C1q).

  1974cited by this paper
• Isolation and characterization of the proenzyme form of the C1r subunit of the first complement component.

  1974cited by this paper
• Effector activating determinants on IgG. II. Differentiation of the combining sites for C1q from those for cytotoxic K cells and neutrophils by plasmin digestion of rabbits IgG.

  1974cited by this paper
• Studies on the structure and activity of rabbit Clq (a subcomponent of the first component of complement).

  1974cited by this paper
• Purification, Molecular Properties, and Activation of C1 Proesterase, Cls

  1973cited by this paper
• The first component of complement in serum: evidence for a hitherto unrecognized factor in C1 necessary for internal activation.

  1973cited by this paper
• Collagen-induced platelet aggregation: involement of an active glycopeptide fragment (alpha1-CB5).

  1973cited by this paper
• Effect of chemical and enzymatic radioiodination on in vitro human Clq activities.

  1973cited by this paper
• Activation of the complement system.

  1973cited by this paper
• Purification of C 1S , a subunit of the first component of complement from human plasma.

  1973cited by this paper
• Zymogens of Proteolytic Enzymes

  1973cited by this paper
• Collagen-Induced Platelet Aggregation: Involvement of an Active Glycopeptide Fragment (α1-CB5)

  1973cited by this paper
• Purification, Characterization and Active-Site Studies on Human Serum Complement Subcomponent C1s

  1973cited by this paper
• A fragment corresponding to the CH2 region of immunoglobulin G (IgG) with complement fixing activity

  1972cited by this paper
• Ultrastructure of the Human Complement Component, Clq

  1972cited by this paper
• Structural studies on human Clq: non-covalent and covalent subunits.

  1972cited by this paper
• Ultrastructure of human C1q protein.

  1972cited by this paper
• Immunoglobulin M: Fixation of Human Complement by the Fc Fragment

  1972cited by this paper
• C1r deficiency: an inborn error associated with cutaneous and renal disease.

  1972cited by this paper
• Ultrastructure of the human complement component, Clq (negative staining-glutamine synthetase-biologically active Clq).

  1972cited by this paper
• Fluid phase destruction of C2 hu by C1 hu. 3. Changes in activity for synthetic substrates upon cell binding, heat inactivation and interaction with C1INH.

  1972cited by this paper
• Isolation and characterization of C1q, a subcomponent of the first component of complement, from human and rabbit sera.

  1972cited by this paper
• Fb, a ndw enzymatic fragment of human G immunoglobulin.

  1972cited by this paper
• Resolution of the first component of guinea pig complement into three subunits, Clq, Clr and Cls, and their hybridization with human Cl subunits.

  1972cited by this paper
• Rabbit C1q: purification, functional and structural studies.

  1972cited by this paper
• C1q protein of human complement.

  1972cited by this paper
• Ultrastructural Studies of Clq and of Complement-Membrane Interactions**This is publication number 520 from the Department of Experimental Pathology, Scripps Clinic and Research Foundation, La Jolla, California 92037. This work was supported by United States Public Health Service Grant Al-07007.

  1971cited by this paper
• A new enzymic fragment (Facb) of rabbit immunoglobulin G.

  1971cited by this paper
• Chemical studies of Clq; a modulator of immunoglobulin biology.

  1971cited by this paper
• The reaction of monomeric and aggregated immunoglobulins with C1.

  1971cited by this paper
• Purification of the human complement protein C1s by affinity chromatograhy.

  1971cited by this paper
• Purification of the human complement protein C1q by affinity chromatography.

  1971cited by this paper
• The chemistry and structure of collagen.

  1971cited by this paper
• Complement fixation by the F(ab')2-fragment of pepsin-treated rabbit antibody.

  1971cited by this paper
• Function and physical properties of two distinct forms of the first component of guinea pig complement.

  1971cited by this paper
• C1q: Rapid Purification Method for Preparation of Monospecific Antisera and for Biochemical Studies

  1971cited by this paper
• C1r, subunit of the first complement component: purification, properties, and assay based on its linking role.

  1971cited by this paper
• Precipitin reactions of the C1q component of complement with aggregated gamma-globulin and immune complexes in gel diffusion.

  1970cited by this paper
• DEFICIENCY OF C1r IN HUMAN SERUM

  1970cited by this paper
• THE FIXATION OF COMPLEMENT AND THE ACTIVATED FIRST COMPONENT (C1) OF COMPLEMENT BY COMPLEXES FORMED BETWEEN ANTIBODY AND DIVALENT HAPTEN

  1970cited by this paper
• FLUID PHASE DESTRUCTION OF C2hu BY C1hu

  1969cited by this paper
• Purification of the first component of complement by zonal ultracentrifugation.

  1969cited by this paper
• The role of c'1q, cations, and ionic strength in the formation of C'1 esterase.

  1969cited by this paper
• The pH-dependence of the binding of competitive inhibitors to pepsin.

  1969cited by this paper
• Immunoglobulin Peptide with Complement Fixing Activity

  1969cited by this paper
• The relationship of the hemolytic activity of active C'1s to its TAMe esterase action: a new method of purification and assay.

  1969cited by this paper
• Stepwise cleavage of rabbit immunoglobulin G by papain and isolation of four types of biologically active Fc fragments.

  1969cited by this paper
• FLUID PHASE DESTRUCTION OF C2hu BY C1hu

  1969cited by this paper
• Chemistry and reaction mechanisms of complement.

  1968cited by this paper
• THE ENZYMATIC NATURE OF C'1r

  1968cited by this paper
• The purification and reactivity of the first component of complement from guinea pig, human and canine sera.

  1968cited by this paper
• Progress in immunology. Syndromes of diminished resistance to infection.

  1968cited by this paper
• Complement: purification of the first component from rabbit and guinea pig serum.

  1968cited by this paper
• Reversible loss of activity of the first component of complement (C'1) as a function of ionic strength.

  1968cited by this paper
• Ultracentrifugation of the first component of complement: effects of ionic strength.

  1968cited by this paper
• Studies on the renal glomerular basement membrane. Preparation and chemical composition.

  1967cited by this paper
• Electron microscopy of an antibody-hapten complex.

  1967cited by this paper
• Activation of C'1 to C'1 esterase on gel filtration on Sephadex G-200. Studies on normal human serum, euglobulin and hereditary angioneurotic edema serum.

  1966cited by this paper
• Methods for the separation, purification and measurement of nine components of hemolytic complement in guinea-pig serum.

  1966cited by this paper
• Interaction between C′1q and γG-globulin

  1966cited by this paper
• Some physical-chemical properties of chicken gamma-globulins and their pepsin and papain digestion products.

  1966cited by this paper
• Atlas of protein sequence and structure

  1965cited by this paper
• STUDIES ON HUMAN C'1-ESTERASE. I. PURIFICATION AND ENZYMATIC PROPERTIES.

  1964cited by this paper
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  1964cited by this paper
• THE MACROMOLECULAR NATURE OF THE FIRST COMPONENT OF HUMAN COMPLEMENT

  1964cited by this paper
• CHROMATOGRAPHIC RESOLUTION OF THE FIRST COMPONENT OF HUMAN COMPLEMENT INTO THREE ACTIVITIES

  1963cited by this paper
• PEPSIN DIGESTION OF RABBIT AND SHEEP ANTIBODIES. THE EFFECT ON COMPLEMENT FIXATION.

  1963cited by this paper
• PEPSIN DIGESTION OF RABBIT AND SHEEP ANTIBODIES

  1963cited by this paper
• Reduction and Reoxidation of a Critical Disulfide Bond in the Rabbit Antibody Molecule

  1963cited by this paper
• Isolation of a Thermolabile Serum Protein which Precipitates γ-Globulin Aggregates and Participates in Immune Hemolysis.∗

  1961cited by this paper
• Complement Fixation by Antibody Fragments

  1961cited by this paper
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  1960cited by this paper
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  1956cited by this paper
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  1954cited by this paper

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  1992cites this paper
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  1988cites this paper
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  1987cites this paper
• Modes of attachment of acetylcholinesterase to the surface membrane.

  1987cites this paper
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  1985cites this paper
• Segmental flexibility of the C1q subcomponent of human complement and its possible role in the immune response.

  1985cites this paper
• Rodney Robert Porter

  1985cites this paper
• The role of non-immune IgG in controlling IgG-mediated effector functions.

  1983cites this paper
• Measurement of the association constants of the complexes formed between intact C1q or pepsin-treated C1q stalks and the unactivated or activated C1r2C1s2 tetramers.

  1983cites this paper
• The limited fragmentation of porcine haemolytic immunoglobulin M. Evidence that haemolytic activity depends on the number of Fab arms that can attach to the erythrocyte surface.

  1982cites this paper
• C1q binding to antibody-coated cells: predictions from a simple multivalent binding model.

  1981cites this paper
• Molecular aspects of complement activation

  1981cites this paper
• The Complement System

  1981cites this paper
• Inhibition of immune complex-mediated activation of complement

  1980cites this paper
• Fixation of frog and guinea pig complement by antibodies from the bullfrog, Rana catesbeiana.

  1980cites this paper
• (p-Amidinophenyl)methanesulfonyl fluoride, an irreversible inhibitor of serine proteases.

  1980cites this paper
• Receptors for complement of Langerhans cells.

  1980cites this paper
• Complement and cell-mediated lysis of haptenated erythrocytes sensitized with oligomers of rabbit IgG antibody.

  1979cites this paper
• Humoral Immunity to Viruses

  1979cites this paper
• CHAPTER 4 – Complement

  1979cites this paper
• Activation of the first component of human complement (C1) by antibody-antigen aggregates.

  1978cites this paper
• A molecular approach to the complement system.

  1978cites this paper
• Immunoglobulin structure and effector functions.

  1978cites this paper
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  1978cites this paper
• The isolation and structure of C4, the fourth component of human complement.

  1977cites this paper
• 2 – Immunoglobulins II. Antibody Specificity and Genetic Control

  1977cites this paper
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  1977cites this paper
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  1977cites this paper
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  1976cites this paper
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  1976cites this paper
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  1976cites this paper
• Immunochemistry and immunobiology of the complement system.

  1976cites this paper