Role of the adenovirus early region 1B tumor antigens in transformation and lytic infection.

No abstract is available for this paper.

• Publication year

  1986

• Venue

  Virology

• Publication date

  1986-04-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/0042-6822(86)90272-2PMID 2937199
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The 2.2 kb El b mRNA of Human Ad1 2 and Ad5 Codes for Two Tumor Antigens Starting at Different AUG Triplets

  2004cited by this paper
• Localization of the E1B proteins of adenovirus 5 in transformed cells, as revealed by interaction with monoclonal antibodies.

  1985cited by this paper
• 19-kDa tumor antigen coded by early region E1b of adenovirus 2 is required for efficient synthesis and for protection of viral DNA.

  1984cited by this paper
• Oncogenicity by adenovirus is not determined by the transforming region only

  1984cited by this paper
• Isolation of transformation-defective, replication-nondefective early region 1B mutants of adenovirus 12

  1984cited by this paper
• cyt gene of adenoviruses 2 and 5 is an oncogene for transforming function in early region E1B and encodes the E1B 19,000-molecular-weight polypeptide

  1984influential reference
• Mutations in the gene encoding the adenovirus early region 1B 19,000-molecular-weight tumor antigen cause the degradation of chromosomal DNA

  1984influential reference
• Effect on transformation of mutations in the early region 1b-encoded 21- and 55-kilodalton proteins of adenovirus 5

  1984influential reference
• Adenovirus cyt+ locus, which controls cell transformation and tumorigenicity, is an allele of lp+ locus, which codes for a 19-kilodalton tumor antigen

  1984cited by this paper
• Early region 1B of adenovirus 2 encodes two coterminal proteins of 495 and 155 amino acid residues

  1984cited by this paper
• Deletion of the gene encoding the adenovirus 5 early region 1b 21,000-molecular-weight polypeptide leads to degradation of viral and host cell DNA

  1984influential reference
• Role of adenovirus types 5 and 12 early region 1b tumor antigens in oncogenic transformation.

  1983cited by this paper
• Adenovirus 2 lp+ locus codes for a 19 kd tumor antigen that plays an essential role in cell transformation

  1983influential reference
• Transformation of rat cells by cyt mutants of adenovirus type 12 and mutants of adenovirus type 5

  1983cited by this paper
• Transformation of rodent cells by DNA extracted from transformation-defective adenovirus mutants

  1983cited by this paper
• Construction and characterization of an adenovirus type 5/adenovirus type 12 recombinant virus.

  1983cited by this paper
• Differential expression of cellular oncogenes during pre- and postnatal development of the mouse

  1982cited by this paper
• The relationship between region E1a and E1b of human adenoviruses in cell transformation.

  1982cited by this paper
• Isolation of type 5 adenovirus mutants with a cold-sensitive host range phenotype: genetic evidence of an adenovirus transformation maintenance function.

  1982cited by this paper
• Characterization of cells transformed by Ad5/Ad12 hybrid early region I plasmids.

  1982cited by this paper
• Expression of early viral gene products in adenovirus type 12-infected and -transformed cells.

  1982cited by this paper
• Different mRNAs from the transforming region of highly oncogenic and non-oncogenic human adenoviruses

  1982cited by this paper
• Identification of adenovirus-type 12 gene products involved in transformation and oncogenesis.

  1982cited by this paper
• Incomplete transformation of rat cells by a deletion mutant of adenovirus type 5

  1981cited by this paper
• Early viral proteins in HeLa cells infected with adenovirus type 5 host range mutants.

  1980cited by this paper
• Functional analysis of adenovirus-5 host-range deletion mutants defective for transformation of rat embryo cells.

  1980cited by this paper
• Identification and mapping of the early gene products of adenovirus type 12.

  1980cited by this paper
• Partial transformation of primary rat cells by the leftmost 4.5% fragment of adenovirus 5 DNA.

  1980cited by this paper
• The gene for polypeptide IX of adenovirus type 2 and its unspliced messenger RNA.

  1980cited by this paper
• Assay of transforming activity of tumor virus DNA.

  1980cited by this paper
• Characterization of tumor antigens in cells transformed by fragments of adenovirus type 5 DNA.

  1979cited by this paper
• In vitro translation products specified by the transforming region of adenovirus type 2

  1979cited by this paper
• Tumor antigens of human Ad5 in transformed cells and in cells infected with transformation-defective host-range mutants.

  1979cited by this paper
• Isolation of adenovirus type 5 host range deletion mutants defective for transformation of rat embryo cells.

  1979cited by this paper
• Incomplete transformation of rat cells by a small fragment of adenovirus 12 DNA.

  1979cited by this paper
• Mapping of RNA initiation sites by high doses of uv irradiation: evidence for three independent promoters within the left 11% of the Ad-2 genome.

  1979cited by this paper
• Adenovirus 5 DNA sequences present and RNA sequences transcribed in transformed human embryo kidney cells (HEK-Ad-5 or 293).

  1979cited by this paper
• Mapping temperature-sensitive and host-range mutations of adenovirus type 5 by marker rescue.

  1978cited by this paper
• Defective transforming capacity of adenovirus type 5 host-range mutants.

  1978cited by this paper
• Transformation with specific fragments of adenovirus DNAs. II. Analysis of the viral DNA sequences present in cells transformed with a 7% fragment of adenovirus 5 DNA.

  1977cited by this paper
• Host-range mutants of adenovirus type 5 defective for growth in HeLa cells.

  1977cited by this paper
• Studies on in vitro transformation by DNA and DNA fragments of human adenoviruses and simian virus 40.

  1975cited by this paper
• Size and location of the transforming region in human adenovirus type 5 DNA

  1974cited by this paper
• Interactions of adenovirus type 2 with rat embryo cells. Permissiveness, transformation and in vitro characteristics of adenovirus transformed rat embryo cells.

  1974cited by this paper
• Viral DNA in transformed cells. II. A study of the sequences of adenovirus 2 DNA IN NINE LINES OF TRANSFORMED RAT CELLS USING SPECIFIC FRAGMENTS OF THE VIRAL GENOME;.

  1974cited by this paper
• Viral DNA in transformed cells. I. A study of the sequences of adenovirus 2 DNA in a line of transformed rat cells using specific fragments of the viral genome.

  1974cited by this paper
• Methods in Enzymology , Vol

  1966cited by this paper

• Cell transformation by the adenovirus oncogenes E1 and E4

  2019cites this paper
• Impact of E1 and Cre on Adenovirus Vector Amplification: Developing MDCK CAV-2-E1 and E1-Cre Transcomplementing Cell Lines

  2013cites this paper
• The effect of Adenovirus E1A on the human immunoproteasome and MHC complex

  2012cites this paper
• Adenovirus E1B 55-Kilodalton Protein: Multiple Roles in Viral Infection and Cell Transformation

  2009cites this paper
• The Adenoviral E1B 55-Kilodalton Protein Controls Expression of Immune Response Genes but Not p53-Dependent Transcription

  2009cites this paper
• Modification of the Rb-Binding Domain of Replication-Competent Adenoviral Vector Enhances Cytotoxicity Against Human Esophageal Cancers via NF-κB Activity

  2007cites this paper
• Characterization of the 55 K adenovirus type 5 E 1 B product and related proteins

  2007influential citation
• Bcl-2 antisense oligonucleotide overcomes resistance to E1A gene therapy in a low HER2-expressing ovarian cancer xenograft model.

  2005cites this paper
• The quest for new improved adenovirus gene therapy vectors against glioma tumours

  2005cites this paper
• Cell transformation by human adenoviruses.

  2004cites this paper
• Adenovirus Type 5 EBB Protein Regulates Transforming Activity

  2003influential citation
• Medizinische Fakultät

  2002cites this paper
• Adenovirus and cell cycle control.

  2002cites this paper
• Nuclear export of adenovirus RNA.

  2001cites this paper
• The Replicative Capacities of Large E1B-Null Group A and Group C Adenoviruses Are Independent of Host Cell p53 Status

  1999influential citation
• The adenovirus E4orf6 protein contributes to malignant transformation by antagonizing E1A-induced accumulation of the tumor suppressor protein p53

  1999cites this paper
• p53 Status Does Not Determine Outcome of E1B 55-Kilodalton Mutant Adenovirus Lytic Infection

  1998cites this paper
• trans E1 component requirements for maximal replication of E1-defective recombinant adenovirus.

  1998cites this paper
• Replication of ONYX-015, a Potential Anticancer Adenovirus, Is Independent of p53 Status in Tumor Cells

  1998cites this paper
• Control of Apoptosis by Human Adenovirus Genes

  1998cites this paper
• Adenovirus E1B 19K protein is required for efficient DNA replication in U937 cells.

  1997cites this paper
• Inhibition of p53-mediated transactivation and cell cycle arrest by E1A through its p300/CBP-interacting region

  1997cites this paper
• Regulation of p53-dependent apoptosis, transcriptional repression, and cell transformation by phosphorylation of the 55-kilodalton E1B protein of human adenovirus type 5

  1997cites this paper
• Adenovirus type 40 host range in tissue culture : replication and gene expression in INT407 cells

  1997cites this paper
• Adenovirus Type 5 Early Region 4 Is Responsible for E 1 A-Induced p 53-Independent Apoptosis

  1996cites this paper
• Adenovirus type 5 early region 4 is responsible for E1A-induced p53-independent apoptosis

  1996cites this paper
• Viral proteins E1B19K and p35 protect sympathetic neurons from cell death induced by NGF deprivation

  1995cites this paper
• Adenovirus E1A243 disrupts the ATF/CREB-YY1 complex at the mouse c-fos promoter

  1995cites this paper
• The subgroup F adenoviruses.

  1995cites this paper
• Regulation of p53-dependent apoptosis by E1A and E1B.

  1995cites this paper
• Molecular Biology of Virally-Induced Cell Transformation and Tumorigenesis

  1995cites this paper
• An adenovirus type 5 early region 1B-encoded CTL epitope-mediating tumor eradication by CTL clones is down-modulated by an activated ras oncogene.

  1995cites this paper
• Adenovirus E1A proteins induce apoptosis by both p53-dependent and p53-independent mechanisms.

  1995cites this paper
• Characterization of the 55K adenovirus type 5 E1B product and related proteins.

  1994influential citation
• Absence of an essential regulatory influence of the adenovirus E1B 19-kilodalton protein on viral growth and early gene expression in human diploid WI38, HeLa, and A549 cells

  1994cites this paper
• Phosphorylation at the carboxy terminus of the 55-kilodalton adenovirus type 5 E1B protein regulates transforming activity

  1994cites this paper
• Abrogation of oncogene-associated apoptosis allows transformation of p53-deficient cells.

  1994cites this paper
• Stabilization of the p53 tumor suppressor is induced by adenovirus 5 E1A and accompanies apoptosis.

  1993cites this paper
• Increased cyclin A and decreased cyclin D levels in adenovirus 5 E1A-transformed rodent cell lines.

  1993cites this paper
• The E1B 19-kilodalton protein is not essential for transformation of rodent cells in vitro by adenovirus type 5

  1993influential citation
• Mutational analysis of the transforming and apoptosis suppression activities of the adenovirus E1B 175R protein.

  1993cites this paper
• Adenovirus type 12 early region 1B proteins and metabolism of early viral mRNAs.

  1992cites this paper
• A block in release of progeny virus and a high particle-to-infectious unit ratio contribute to poor growth of enteric adenovirus types 40 and 41 in cell culture

  1992cites this paper
• The adenovirus E1A proteins induce apoptosis, which is inhibited by the E1B 19-kDa and Bcl-2 proteins.

  1992cites this paper
• The 19-kilodalton adenovirus E1B transforming protein inhibits programmed cell death and prevents cytolysis by tumor necrosis factor alpha

  1992cites this paper
• Overexpression of the E1B 55-kilodalton (482R) protein of human adenovirus type 12 appears to permit efficient transformation of primary baby rat kidney cells in the absence of the E1B 19-kilodalton protein

  1992cites this paper
• Individual adenovirus E1B proteins induce transformation independently but by additive pathways.

  1991cites this paper
• The E1B 19,000-molecular-weight protein of group C adenoviruses prevents tumor necrosis factor cytolysis of human cells but not of mouse cells

  1991cites this paper
• Role of adenovirus E1B proteins in transformation: altered organization of intermediate filaments in transformed cells that express the 19-kilodalton protein

  1990influential citation
• Enteric adenovirus type 40: expression of E1B mRNA and proteins in permissive and nonpermissive cells.

  1990cites this paper
• Role of adenovirus type 2 early region 1B 19K protein stability in expression of the cyt and deg phenotypes.

  1989cites this paper
• The adenovirus E1B 19-kilodalton protein stimulates gene expression by increasing DNA levels

  1989cites this paper
• Mapping of a phosphorylation site in the 176R (19 kDa) early region 1B protein of human adenovirus type 5.

  1989cites this paper
• Adenovirus region E3 proteins that prevent cytolysis by cytotoxic T cells and tumor necrosis factor.

  1989cites this paper
• Adenovirus type 12 E1B 19-kilodalton protein is not required for oncogenic transformation in rats

  1988influential citation
• Host range mutants of adenovirus type 12 E1 defective for lytic infection, transformation, and oncogenicity.

  1988cites this paper
• Role of the adenovirus E1B 19,000-dalton tumor antigen in regulating early gene expression

  1988cites this paper
• A cell cycle G0-ts mutant, tsJT60, becomes lethal at the nonpermissive temperature after transformation with adenovirus 12 E1B 19K mutant.

  1988cites this paper
• Adenovirus proteins from both E1B reading frames are required for transformation of rodent cells by viral infection and DNA transfection.

  1987cites this paper
• Adenovirus transforming 19-kD T antigen has an enhancer-dependent trans-activation function and relieves enhancer repression mediated by viral and cellular genes.

  1987cites this paper
• Transactivation of host and viral genes by the adenovirus E1B 19K tumor antigen.

  1987cites this paper
• Activation of adenovirus 5 E1A transcription by region E1B in transformed primary rat cells.

  1987cites this paper
• Expression of adenovirus E1B mutant phenotypes is dependent on the host cell and on synthesis of E1A proteins

  1987cites this paper
• Identification of adenovirus type 2 early region 1B proteins that share the same amino terminus as do the 495R and 155R proteins

  1987cites this paper
• Requirement of conditioned medium or a high concentration of serum for anchorage-independent growth of adenovirus type 12 E1a-transformed rat cells (HY1).

  1987cites this paper