Effects of 6-hydroxydopamine on the activity of tyrosine hydroxylase and dopamine- -hydroxylase in sympathetic ganglia of the rat.

Administration of 6-OH-dopamine daily for two days causes a nearly complete depletion of endogenous norepinephrine and a persistent, although not total, loss of activity of dopamine-β-hydroxylase from the heart. In adrenal glands, 6-OH-dopamine administration increases the activity both of tyrosine hydroxylase and dopainine-β-hydroxylase without affecting catecholamine levels. In both normally innervated and decentralized sympathetic ganglia, administration of 6-OH-dopamine causes no change in tyrosine hydroxylase activity and a long-lasting 50% decrease in dopamine-β-hydroxylase activity. Pretreatment with 6-OH-dopamine prevents reserpine-induced. increases in the activity of these enzymes in ganglia. A similar effect is also produced by surgical section of the postganglionic axons of the superior cervical ganglion.

• Publication year

  1971

• Venue

  Journal of Pharmacology and Experimental Therapeutics

• Publication date

  1971-09-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/s0022-3565(25)28974-1PMID 4105924
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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