Cellular Functions of Optineurin in Health and Disease.

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Trends in immunology

• Publication date

  2016-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.it.2016.07.002PMID 27480243
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Defects in autophagy caused by glaucoma-associated mutations in optineurin.

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• The role for autophagy in cancer.

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• Optineurin Negatively Regulates Osteoclast Differentiation by Modulating NF-κB and Interferon Signaling: Implications for Paget’s Disease

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• A Glaucoma-Associated Variant of Optineurin, M98K, Activates Tbk1 to Enhance Autophagosome Formation and Retinal Cell Death Dependent on Ser177 Phosphorylation of Optineurin

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• Optineurin deficiency in mice contributes to impaired cytokine secretion and neutrophil recruitment in bacteria-driven colitis

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• Whole-genome sequencing reveals important role for TBK1 and OPTN mutations in frontotemporal lobar degeneration without motor neuron disease

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• Loss of neuronal Miro1 disrupts mitophagy and induces hyperactivation of the integrated stress response

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• The PINK1-PARKIN Mitochondrial Ubiquitylation Pathway Drives a Program of OPTN/NDP52 Recruitment and TBK1 Activation to Promote Mitophagy.

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• Optineurin Regulates the Interferon Response in a Cell Cycle-Dependent Manner

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• Mutations in the ubiquitin-binding domain of OPTN/optineurin interfere with autophagy-mediated degradation of misfolded proteins by a dominant-negative mechanism

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• Cargo recognition and trafficking in selective autophagy

  2014cited by this paper
• Pathobiology of Paget's Disease of Bone

  2014cited by this paper
• Ubiquitin is phosphorylated by PINK1 to activate parkin

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• Optineurin is an autophagy receptor for damaged mitochondria in parkin-mediated mitophagy that is disrupted by an ALS-linked mutation

  2014cited by this paper
• Ubiquitylation of autophagy receptor Optineurin by HACE1 activates selective autophagy for tumor suppression.

  2014cited by this paper
• A20 in inflammation and autoimmunity.

  2014cited by this paper
• Disruption of macrophage pro-inflammatory cytokine release in Crohn's disease is associated with reduced optineurin expression in a subset of patients

  2014cited by this paper
• Enhanced optineurin E50K-TBK1 interaction evokes protein insolubility and initiates familial primary open-angle glaucoma.

  2013cited by this paper
• M98K-OPTN induces transferrin receptor degradation and RAB12-mediated autophagic death in retinal ganglion cells

  2013cited by this paper
• Optineurin suppression causes neuronal cell death via NF‐κB pathway

  2013cited by this paper
• Ubiquitin-independent function of optineurin in autophagic clearance of protein aggregates

  2013cited by this paper
• RNA dysfunction and aggrephagy at the centre of an amyotrophic lateral sclerosis/frontotemporal dementia disease continuum.

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• Novel heterozygous nonsense mutation of the OPTN gene segregating in a Danish family with ALS.

  2012cited by this paper
• Optineurin in Huntington's disease intranuclear inclusions.

  2012cited by this paper
• Depletion of optineurin in RGC-5 cells derived from retinal neurons causes apoptosis and reduces the secretion of neurotrophins.

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• Copy number variations on chromosome 12q14 in patients with normal tension glaucoma.

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• Myosin VI and its binding partner optineurin are involved in secretory vesicle fusion at the plasma membrane

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• Optineurin in neurodegenerative diseases

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• Phosphorylation of the Autophagy Receptor Optineurin Restricts Salmonella Growth

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• Optineurin Is Required for CYLD-Dependent Inhibition of TNFα-Induced NF-κB Activation

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• Polyubiquitin Binding to Optineurin Is Required for Optimal Activation of TANK-binding Kinase 1 and Production of Interferon β*

  2011cited by this paper
• Mutations of optineurin in amyotrophic lateral sclerosis

  2010cited by this paper
• Genome wide association study identifies variants at CSF1, OPTN and TNFRSF11A as genetic risk factors for Paget’s disease of bone

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• Optineurin Negatively Regulates the Induction of IFNβ in Response to RNA Virus Infection

  2010cited by this paper
• The majority of the genetic risk for Paget’s disease of bone is explained by genetic variants close to the CSF1, OPTN, TM7SF4, and TNFRSF11A genes

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• Overexpression of optineurin E50K disrupts Rab8 interaction and leads to a progressive retinal degeneration in mice

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• Mechanisms of mitophagy

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• NF-κB Mediates Tumor Necrosis Factor α-Induced Expression of Optineurin, a Negative Regulator of NF-κB

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• Disordered macrophage cytokine secretion underlies impaired acute inflammation and bacterial clearance in Crohn's disease

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• NRP/Optineurin Cooperates with TAX1BP1 to Potentiate the Activation of NF-κB by Human T-Lymphotropic Virus Type 1 Tax Protein

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• Enhanced binding of TBK1 by an optineurin mutant that causes a familial form of primary open angle glaucoma

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• A glaucoma-associated mutant of optineurin selectively induces death of retinal ganglion cells which is inhibited by antioxidants.

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• Ultrastructure of retinal capillaries of the rat.

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