Formal Demonstration of the Phosphorylation of Rat Brain Tryptophan Hydroxylase by Ca2+/Calmodulin‐Dependent Protein Kinase

No abstract is available for this paper.

• Publication year

  1989

• Venue

  Journal of Neurochemistry

• Publication date

  1989-06-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1111/j.1471-4159.1989.tb07272.xPMID 2542452
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The immunolysis, isolation, and properties of subpopulations of mammalian brain synaptosomes

  1989cited by this paper
• Sequence of Two mRNAs Encoding Active Rat Tryptophan Hydroxylase

  1988cited by this paper
• Regional distribution in rat brain of tryptophan hydroxylase apoenzyme determined by enzyme-linked immunoassay.

  1987cited by this paper
• RAT BRAIN TRYPTOPHAN HYDROXYLASE : PURIFICATION, ACTIVATION AND STABILISATION

  1987cited by this paper
• Phosphorylation of Purified Rat Striatal Tyrosine Hydroxylase by Ca2+/Calmodulin‐Dependent Protein Kinase II: Effect of an Activator Protein

  1987cited by this paper
• Full-length cDNA for rabbit tryptophan hydroxylase: functional domains and evolution of aromatic amino acid hydroxylases.

  1987cited by this paper
• Brain 14‐3‐3 protein is an activator protein that activates tryptophan 5‐monooxygenase and tyrosine 3‐monooxygenase in the presence of Ca2+,calmodulin‐dependent protein kinase II

  1987cited by this paper
• Phosphorylation of Tyrosine Hydroxylase by Cyclic GMP‐Dependent Protein Kinase

  1987cited by this paper
• Immunohistochemistry of tryptophan hydroxylase in the rat brain.

  1987cited by this paper
• Regulation of tryptophan hydroxylase activity by a cyclic AMP-dependent mechanism in rat striatum.

  1987cited by this paper
• Activation of the multifunctional Ca2+/calmodulin-dependent protein kinase by autophosphorylation: ATP modulates production of an autonomous enzyme.

  1986cited by this paper
• Isolation of a rat pineal gland cDNA clone homologous to tyrosine and phenylalanine hydroxylases

  1986cited by this paper
• Tryptophan hydroxylase: increase in activity by electrical stimulation of serotonergic neurons.

  1986cited by this paper
• Tryptophan 5-hydroxylase. Rapid purification from whole rat brain and production of a specific antiserum.

  1985cited by this paper
• Characteristics of Tyrosine Hydroxylase Activation by K+‐Induced Depolarization and/or Forskolin in Rat Striatal Slices

  1985cited by this paper
• Substrate specificity of a multifunctional calmodulin-dependent protein kinase.

  1985cited by this paper
• Characterization of the sites phosphorylated on tyrosine hydroxylase by Ca2+ and phospholipid‐dependent protein kinase, calmodulin‐dependent multiprotein kinase and cyclic AMP‐dependent protein kinase

  1985cited by this paper
• Calcium/phospholipid-dependent protein kinase (protein kinase C) phosphorylates and activates tyrosine hydroxylase.

  1984cited by this paper
• Removal of phosphate from proteins by the reverse reaction.

  1983cited by this paper
• Purification and Characterization of a Ca2+‐ and Calmodulin‐Dependent Protein Kinase from Rat Brain

  1982cited by this paper
• Further studies on the role of calcium in the depolarization-induced activation of tryptophan hydroxylase. Effect of verapamil, Tetracaine, haloperidol and fluphenazine.

  1982cited by this paper
• Tyrosine 3-monoxygenase is phosphorylated by Ca2+-, calmodulin-dependent protein kinase, followed by activation by activator protein.

  1981cited by this paper
• A new activator protein that activates tryptophan 5-monooxygenase and tyrosine 3-monooxygenase in the presence of Ca2+-, calmodulin-dependent protein kinase. Purification and characterization.

  1981cited by this paper
• Activation of brain tryptophan hydroxylase by ATP-MG2+: dependence on calmodulin.

  1980cited by this paper
• Evidence for three distinct forms of calmodulin‐dependent protein kinases from rat brain

  1980cited by this paper
• Activation of tryptophan hydroxylase from slices of rat brain stem incubates with N6, 02'-dibutyryl adenosine-3':5'-cyclic monophosphate.

  1980cited by this paper
• Tyrosine hydroxylase: a substrate of cyclic AMP-dependent protein kinase.

  1980cited by this paper
• In vitro phosphorylation of bovine adrenal tyrosine hydroxylase by adenosine 3':5'-monophosphate-dependent protein kinase.

  1979cited by this paper
• Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

  1979cited by this paper
• Activation of tryptophan hydroxylase from slices of rat brain stem incubated with agents which promote calcium uptake or intraneuronal release.

  1979cited by this paper
• THE ROLE OF INTRANEURONAL 5‐HT AND OF TRYPTOPHAN HYDROXYLASE ACTIVATION IN THE CONTROL OF 5‐HT SYNTHESIS IN RAT BRAIN SLICES INCUBATED IN K+‐ENRICHED MEDIUM

  1979cited by this paper
• Activation of tryptophan hydroxylase by adenosine triphosphate, magnesium, and calcium.

  1978cited by this paper
• Calcium-dependent activation of tryptophan hydroxylase by ATP and magnesium.

  1978cited by this paper
• Activation of brain typtophan hydroxylase by a phosphorylating system

  1978cited by this paper
• RAT BRAIN STEM TRYPTOPHAN HYDROXYLASE: MECHANISM OF ACTIVATION BY CALCIUM

  1977cited by this paper
• Tryptophan hydroxylase in the rat brain.

  1975cited by this paper
• Rapid nonisotopic assay of tryptophan-5-hydroxylase activity in tissues.

  1973cited by this paper
• Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

  1970cited by this paper
• Tryptophan Hydroxylation: Measurement in Pineal Gland, Brainstem, and Carcinoid Tumor

  1967cited by this paper
• Tryptophan hydroxylation in brain.

  1964cited by this paper
• Protein measurement with the Folin phenol reagent.

  1951cited by this paper

• Melatonin Synthesis Enzymes Activity: Radiometric Assays for AANAT, ASMT, and TPH.

  2022cites this paper
• 5-Hydroxytryptophan (5-HTP): Natural Occurrence, Analysis, Biosynthesis, Biotechnology, Physiology and Toxicology

  2020cites this paper
• Tryptophan hydroxylase and serotonin synthesis regulation

  2020cites this paper
• Hormones and the Development and Expression of Aggressive Behavior

  2017cites this paper
• Phosphorylation of CaMKII in the rat dorsal raphe nucleus plays an important role in sleep–wake regulation

  2016cites this paper
• Constitutively Elevated Blood Serotonin Is Associated with Bone Loss and Type 2 Diabetes in Rats

  2016cites this paper
• OS EFEITOS DO TREINAMENTO FÍSICO AERÓBIO SOBRE A SÍNTESE DE MELATONINA PINEAL EM RATOS

  2015cites this paper
• Brain Serotonergic Disturbances Caused by Diabetes Mellitus are not Reversed by Insulin Treatment

  2015cites this paper
• αCaMKII autophosphorylation controls the establishment of alcohol-induced conditioned place preference in mice.

  2013cites this paper
• αCaMKII Autophosphorylation Controls the Establishment of Alcohol Drinking Behavior

  2013cites this paper
• A Neuronal Signaling Pathway of CaMKII and Gqα Regulates Experience-Dependent Transcription of tph-1

  2013cites this paper
• Neural Substrates of Experience in Caenorhabditis elegans Olfactory Learning

  2013cites this paper
• Genetic and Epigenetic Determinants of Aggression

  2012cites this paper
• A characterisation and functional analysis of the role of the 14-3-3-like proteins in neuronal ageing in the pond snail, Lymnaea stagnalis

  2012cites this paper
• Single-Prolonged Stress Induce Changes of CaM/CaMKIIα in the Rats of Dorsal Raphe Nucleus

  2012cites this paper
• Patho-Epigenetics of Disease

  2012cites this paper
• AÇÕES DA METILECGONIDINA SOBRE A SÍNTESE DE MELATONINA NA GLÂNDULA PINEAL DE RATOS.

  2011cites this paper
• Influência da Ingestão de Álcool na Produção de Melatonina Pineal e suas Conseqüências sobre a expressão dos receptores de melatonina e dos genes relógio no Sistema Nervoso Central

  2009cites this paper
• Sustained depolarization decreases calcium/calmodulin-dependent protein kinase II activity and gene expression in dopamine neurons.

  2009cites this paper
• Perfil diário e os mecanismos de produção de melatonina pela glândula pineal de ratos diabéticos por estreptozotocina

  2009cites this paper
• Activation and stabilization of human tryptophan hydroxylase 2 by phosphorylation and 14-3-3 binding.

  2008cites this paper
• Tryptophan hydroxylase is modulated by L-type calcium channels in the rat pineal gland.

  2008cites this paper
• Structural Determinants of Post-transcriptional Protein Regulation as Modulators

  2008cites this paper
• 3,4-Methylenedioxymethamphetamine induces differential regulation of tryptophan hydroxylase 2 protein and mRNA levels in the rat dorsal raphe nucleus.

  2008cites this paper
• Role of TPH‐2 in brain function: News from behavioral and pharmacologic studies

  2007cites this paper
• AVALIAÇÃO DAS ALTERAÇÕES CAUSADAS PELO CÂNCER SOBRE A PRODUÇÃO DE MELATONINA NA GLÂNDULA PINEAL

  2007cites this paper
• Developmental role of tryptophan hydroxylase in the nervous system

  2007cites this paper
• Cell‐type specific induction of tryptophan hydroxylase‐2 transcription by calcium mobilization

  2007cites this paper
• Tryptophan metabolism in the central nervous system: medical implications

  2006cites this paper
• Effects of the blockade of high voltage‐activated calcium channels on in vitro pineal melatonin synthesis

  2006cites this paper
• Chronic reduction in dietary tryptophan leads to changes in the emotional response to stress in mice.

  2005cites this paper
• Somatodendritic autoreceptor regulation of serotonergic neurons: dependence on l‐tryptophan and tryptophan hydroxylase‐activating kinases

  2005cites this paper
• Chapter 4.6 – Stress, corticotropin-releasing factor and serotonergic neurotransmission

  2005cites this paper
• Inhibition and kinetic changes of brain tryptophan-5-hydroxylase during insulin-dependent diabetes mellitus in the rat

  2005cites this paper
• New insights into the mechanisms of antidepressant therapy.

  2004cites this paper
• A unique central tryptophan hydroxylase isoform.

  2003cites this paper
• Generation of the Melatonin Endocrine Message in Mammals: A Review of the Complex Regulation of Melatonin Synthesis by Norepinephrine, Peptides, and Other Pineal Transmitters

  2003cites this paper
• Involvement of NF‐Y and Sp1 in basal and cAMP‐stimulated transcriptional activation of the tryptophan hydroxylase (TPH) gene in the pineal gland

  2002cites this paper
• Evidence for involvement of protein kinases in the regulation of serotonin synthesis and turnover in the mouse brain in vivo

  2002cites this paper
• Molecular basis of aggression.

  2001cites this paper
• Regional serotonin metabolism in the brain of transgenic mice lacking monoamine oxidase A

  2001cites this paper
• Autoregulation of Cell-specific MAP Kinase Control of the Tryptophan Hydroxylase Promoter*

  2001cites this paper
• Vivo Serotonin Synthesis Rates in Rat and Human Brain.

  2001cites this paper
• Identification of substrate orienting and phosphorylation sites within tryptophan hydroxylase using homology-based molecular modeling.

  2000cites this paper
• Tryptophan Hydroxylase: Molecular Biology and Regulation

  2000cites this paper
• Day/night variation of tryptophan hydroxylase and serotonin N‐acetyltransferase mRNA levels in the ovine pineal gland and retina

  1999cites this paper
• Chapter 3.1.8 Targeting aggression in mice

  1999cites this paper
• Cloning and expression of recombinant human pineal tryptophan hydroxylase in Escherichia coli: purification and characterization of the cloned enzyme.

  1999cites this paper
• Tetrahydropterin-dependent amino acid hydroxylases.

  1999cites this paper
• Neuropeptide Y increases intracellular calcium in rat pinealocytes

  1999cites this paper
• Advances in the molecular characterization of tryptophan hydroxylase

  1998cites this paper
• Why tryptophan hydroxylase is difficult to purify: a reactive oxygen-derived species-mediated phenomenon that may be implicated in human pathology.

  1998cites this paper
• CBF/NF-Y activates transcription of the human tryptophan hydroxylase gene through an inverted CCAAT box.

  1998cites this paper
• A chimeric tyrosine/tryptophan hydroxylase. The tyrosine hydroxylase regulatory domain serves to stabilize enzyme activity.

  1997cites this paper
• Inhibitors of serine/threonine phosphatases increase membrane-bound choline acetyltransferase activity and enhance acetylcholine synthesis.

  1997cites this paper
• Phosphorylation and Activation of Brain Tryptophan Hydroxylase: Identification of Serine‐58 as a Substrate Site for Protein Kinase A

  1997cites this paper
• A chimeric tyrosine/tryptophan hydroxylase

  1997cites this paper
• Amino‐Terminal Analysis of Tryptophan Hydroxylase: Protein Kinase Phosphorylation Occurs at Serine‐58

  1997cites this paper
• Expression and Deletion Mutagenesis of Tryptophan Hydroxylase Fusion Proteins: Delineation of the Enzyme Catalytic Core

  1996cites this paper
• Localization of mRNA for Ca2+/calmodulin-dependent protein kinase I in the brain of developing and mature rats.

  1996cites this paper
• Phosphorylation and Activation of Tryptophan Hydroxylase by Exogenous Protein Kinase A

  1996cites this paper
• Molecular cloning of chick pineal tryptophan hydroxylase and circadian oscillation of its mRNA levels.

  1996cites this paper
• Characterization of the Human Tryptophan Hydroxylase Gene Promoter

  1995cites this paper
• Structure and function of the aromatic amino acid hydroxylases.

  1995cites this paper
• Developmental regulation of early serotonergic neuronal differentiation: the role of brain-derived neurotrophic factor and membrane depolarization.

  1995cites this paper
• Brain L-Glutamate Decarboxylase

  1995cites this paper
• On the role of brain serotonin in expression of genetic predisposition to catalepsy in animal models.

  1995cites this paper
• Neurotrophins, Depolarization and Second Messengers Interact to Control Serotonergic Neuronal Differentiation

  1995cites this paper
• Adrenocorticotropic hormone activation of adenylate cyclase in raphe neurons: multiple regulatory pathways control serotonergic neuronal differentiation.

  1995cites this paper
• Tryptophan Hydroxylase Is Phosphorylated by Protein Kinase A

  1995cites this paper
• Abnormal fear response and aggressive behavior in mutant mice deficient for alpha-calcium-calmodulin kinase II.

  1994cites this paper
• Recombinant rabbit tryptophan hydroxylase is a substrate for cAMP-dependent protein kinase.

  1994cites this paper
• Intracranial dehydroepiandrosterone blocks the activation of tryptophan hydroxylase in response to acute sound stress.

  1994cites this paper
• Characterization of recombinant mouse tryptophan hydroxylase expressed in Escherichia coli.

  1994cites this paper
• Distinct regulatory pathways control neurofilament expression and neurotransmitter synthesis in immortalized serotonergic neurons

  1994cites this paper
• Early nutritional changes modify the kinetics and phosphorylation capacity of tryptophan‐5‐hydroxylase

  1994cites this paper
• Phosphorylation of Rat Brain Choline Acetyltransferase and Its Relationship to Enzyme Activity

  1993cites this paper
• Regulation of serotonin synthesis.

  1993cites this paper
• Differential expression of mRNAs encoding gamma and delta subunits of Ca2+/calmodulin-dependent protein kinase type II (CaM kinase II) in the mature and postnatally developing rat brain.

  1993cites this paper
• Immobilization of tryptophan hydroxylase by immune adsorption: a method to study regulation of catalytic activity.

  1992cites this paper
• A single locus encodes both phenylalanine hydroxylase and tryptophan hydroxylase activities in Drosophila.

  1992cites this paper
• Increase in cortical and midbrain tryptophan hydroxylase activity by intracerebroventricular administration of corticotropin releasing factor: block by adrenalectomy, by RU 38486 and by bilateral lesions to the central nucleus of the amygdala.

  1992cites this paper
• Distinct forms of the protein kinase-dependent activator of tyrosine and tryptophan hydroxylases.

  1991cites this paper
• Tryptophan Hydroxylase Synthesis Is Induced by 3′, 5′‐Cyclic Adenosine Monophosphate During Circadian Rhythm in the Rat Pineal Gland

  1991cites this paper
• Isolation and structural characterization of the murine tryptophan hydroxylase gene

  1991cites this paper
• Multiple signal transduction mechanisms leading to the secretion of 5- hydroxytryptamine by MTC cells, a neurectodermally derived cell line

  1990cites this paper
• Origin and Metabolism of Serotonin

  1990cites this paper
• The increases in rat cortical and midbrain tryptophan hydroxylase activity in response to acute or repeated sound stress are blocked by bilateral lesions to the central nucleus of the amygdala.

  1990cites this paper
• Increases in the activity of tryptophan hydroxylase from rat cortex and midbrain in response to acute or repeated sound stress are blocked by adrenalectomy and restored by dexamethasone treatment.

  1990cites this paper