Efficacy of the novel dual PI3-kinase/mTOR inhibitor NVP-BEZ235 in a preclinical model of adrenocortical carcinoma.

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Molecular and Cellular Endocrinology

• Publication date

  2012-11-25

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.mce.2012.08.014PMID 22960230
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Combination chemotherapy in advanced adrenocortical carcinoma.

  2012cited by this paper
• The Dual PI3K/mTOR Inhibitor NVP-BEZ235 Induces Tumor Regression in a Genetically Engineered Mouse Model of PIK3CA Wild-Type Colorectal Cancer

  2011cited by this paper
• Adrenocortical carcinoma: a clinician's update

  2011cited by this paper
• NVP-BEZ235 as a New Therapeutic Option for Sarcomas

  2010cited by this paper
• Regulation of insulin-like growth factor-mammalian target of rapamycin signaling by microRNA in childhood adrenocortical tumors.

  2010cited by this paper
• The Efficacy of the Novel Dual PI3-Kinase/mTOR Inhibitor NVP-BEZ235 Compared with Rapamycin in Renal Cell Carcinoma

  2010cited by this paper
• Dual targeting of the PI3K/Akt/mTOR pathway as an antitumor strategy in Waldenstrom macroglobulinemia.

  2010cited by this paper
• Preclinical targeting of the type I insulin-like growth factor receptor in adrenocortical carcinoma.

  2009cited by this paper
• The T cell factor/beta-catenin antagonist PKF115-584 inhibits proliferation of adrenocortical carcinoma cells.

  2008cited by this paper
• Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity

  2008cited by this paper
• mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt.

  2006cited by this paper

• Development and Characterization of 3-Dimensional Cell Culture Models of Adrenocortical Carcinoma

  2024cites this paper
• Acyl-CoA synthetase 4 modulates mitochondrial function in breast cancer cells

  2024cites this paper
• Preclinical Models of Adrenocortical Cancer

  2023cites this paper
• Targeting Oncogenic Wnt/β-Catenin Signaling in Adrenocortical Carcinoma Disrupts ECM Expression and Impairs Tumor Growth

  2023cites this paper
• Hereditary Endocrine Tumor Registries

  2022cites this paper
• Targeting oncogenic Wnt/β-catenin signaling in adrenocortical carcinoma disrupts ECM expression and impairs tumor growth

  2022cites this paper
• Angiotensin II regulates mitochondrial mTOR pathway activity dependent on acyl CoA synthetase 4 in adrenocortical cells.

  2022cites this paper
• The role of mTOR pathway as target for treatment in adrenocortical cancer

  2019cites this paper
• The next step: mechanisms driving adrenocortical carcinoma metastasis.

  2018cites this paper
• Methylation status of Vitamin D receptor gene promoter in adrenocortical carcinoma

  2018cites this paper
• P53/Rb inhibition induces metastatic adrenocortical carcinomas in a preclinical transgenic model

  2017cites this paper
• The role of microRNAs in the pathophysiology of adrenal tumors.

  2017cites this paper
• Establishment of a mouse xenograft model of metastatic adrenocortical carcinoma.

  2017cites this paper
• A 9-cisz retinsav és a mitotán tumorellenes hatásainak és a mikroRNS kifejeződés mintázatának vizsgálata mellékvesekéreg-rák xenograft modelljein

  2017cites this paper
• Establishment of a mouse xenograft model of metastatic adrenocortical carcinoma

  2017cites this paper
• MicroRNA-99a inhibits insulin-induced proliferation, migration, dedifferentiation, and rapamycin resistance of vascular smooth muscle cells by inhibiting insulin-like growth factor-1 receptor and mammalian target of rapamycin.

  2017cites this paper
• Metformin as a new anti-cancer drug in adrenocortical carcinoma

  2016cites this paper
• Effect of API-1 and FR180204 on cell proliferation and apoptosis in human DLD-1 and LoVo colorectal cancer cells

  2016influential citation
• The PI3K/Akt Pathway in Tumors of Endocrine Tissues

  2016cites this paper
• Future directions in the diagnosis and medical treatment of adrenocortical carcinoma.

  2016cites this paper
• Can the Dual Inhibition of Extracellular Signal-Related Kinase (ERK) and Phosphoinositide-3 Kinase (PI3K) Increase Efficacy of Cisplatin in Endometrial and Ovarian Cancers?

  2016cites this paper
• Insulin‐Like Growth Factor—Phosphatidylinositol 3 Kinase Signaling in Canine Cortisol‐Secreting Adrenocortical Tumors

  2015cites this paper
• Molecular pathways of human adrenocortical carcinoma - translating cell signalling knowledge into diagnostic and treatment options.

  2015cites this paper
• Animal models of adrenocortical tumorigenesis.

  2015cites this paper
• Clinical, Magnetic Resonance Imaging, and Histopathologic Findings in 6 Dogs with Surgically resected Extraparenchymal Spinal Cord Hematomas

  2015cites this paper
• Role of the ERK1/2 pathway in tumor chemoresistance and tumor therapy.

  2015cites this paper
• Effect of Orexin-A on Cortisol Secretion in H295R Cells via p70S6K/4EBP1 Signaling Pathway

  2015cites this paper
• Adrenocortical carcinoma: the management of metastatic disease.

  2014cites this paper
• EJE prize 2014: current and evolving treatment options in adrenocortical carcinoma: where do we stand and where do we want to go?

  2014cites this paper
• Pediatric adrenocortical tumors: diagnosis, management and advancements in the understanding of the genetic basis and therapeutic implications

  2014cites this paper
• Curcumin Significantly Enhances Dual PI3K/Akt and mTOR Inhibitor NVP-BEZ235-Induced Apoptosis in Human Renal Carcinoma Caki Cells through Down-Regulation of p53-Dependent Bcl-2 Expression and Inhibition of Mcl-1 Protein Stability

  2014cites this paper
• Genetics and epigenetics of adrenocortical tumors.

  2014cites this paper
• The Combination of Novel Targeted Molecular Agents and Radiation in the Treatment of Pediatric Gliomas

  2013cites this paper
• Studies of NVP-BEZ235 in melanoma.

  2013cites this paper
• mTOR pathway in colorectal cancer: an update

  2013cites this paper
• Lack of long-lasting effects of mitotane adjuvant therapy in a mouse xenograft model of adrenocortical carcinoma.

  2013cites this paper
• Animal models of adrenocortical tumorigenesis.

  2012cites this paper