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Relationship of the polyunsaturated to saturated fatty acid ratio to cardiovascular risk factors and metabolic syndrome in Japanese: the INTERLIPID study.

Zhao Guo,K. Miura,T. Turin,A. Hozawa,N. Okuda,T. Okamura,S. Saitoh,K. Sakata,H. Nakagawa,A. Okayama,K. Yoshita,T. Kadowaki,S. Choudhury,Yasuyuki Nakamura,B. Rodríguez,David Curb,P. Elliott,J. Stamler,H. Ueshima

Published 2010 in Journal of atherosclerosis and thrombosis

ABSTRACT

AIM There have been few studies on the relationships of the dietary polyunsaturated to saturated fatty acid ratio (P/S) to cardiovascular risk factors and metabolic syndrome. We hypothesized that there would be favorable relationships. METHODS Metabolic cardiovascular risk factors from dietary nutrient intake were investigated in 1,004 men and women aged 40-59 years from 4 population samples of Japanese. Multiple linear regression analysis was used to examine the relationship of the dietary P/S ratio to the following risk factors: hemoglobin A1c, blood pressure, serum triglycerides, LDL and total cholesterol, and HDL-cholesterol. Adjusted odds ratio of having metabolic syndrome was also calculated. RESULTS The dietary P/S ratio was significantly and inversely related to serum total and LDL cholesterol with control for possible confounding variables. We did not find any significant relationship between the P/S ratio and single metabolic risk factors or the prevalence of metabolic syndrome. CONCLUSIONS Managing the P/S ratio is important to control serum LDL-cholesterol; however, increasing the P/S ratio may not improve metabolic risk factors. Other countermeasures, such as weight control, greater physical activity, and smoking cessation should be recommended to prevent and control metabolic syndrome.

PUBLICATION RECORD

  • Publication year

    2010

  • Venue

    Journal of atherosclerosis and thrombosis

  • Publication date

    2010-08-31

  • Fields of study

    Agricultural and Food Sciences, Medicine, Biology

  • Identifiers
    DOI 10.5551/JAT.4135PMID 20351467
  • External record

    Open on Semantic Scholar

  • Source metadata

    Semantic Scholar, PubMed

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