Evolution of Antibiotic Resistance without Antibiotic Exposure

ABSTRACT Antibiotic use is the main driver in the emergence of antibiotic resistance. Another unexplored possibility is that resistance evolves coincidentally in response to other selective pressures. We show that selection in the absence of antibiotics can coselect for decreased susceptibility to several antibiotics. Thus, genetic adaptation of bacteria to natural environments may drive resistance evolution by generating a pool of resistance mutations that selection could act on to enrich resistant mutants when antibiotic exposure occurs.

• Publication year

  2017

• Venue

  Antimicrobial Agents and Chemotherapy

• Publication date

  2017-09-11

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/AAC.01495-17PMID 28893783PMCID 5655081
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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