Self-energy-limited ion transport in subnanometer channels.

The current-voltage characteristics of the alpha-Hemolysin protein pore during the passage of single-stranded DNA under varying ionic strength C are studied experimentally. We observe strong blockage of the current, weak superlinear growth of the current as a function of voltage, and a minimum of the current as a function of C. These observations are interpreted as the result of the ion electrostatic self-energy barrier originating from the large difference in the dielectric constants of water and the lipid bilayer. The dependence of DNA capture rate on C also agrees with our model.

• Publication year

  2006

• Venue

  Physical Review Letters

• Publication date

  2006-04-05

• Fields of study

  Biology, Materials Science, Physics, Chemistry, Medicine

• Identifiers
  DOI 10.1103/PhysRevLett.97.128104arXiv cond-mat/0604148PMID 17026003
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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