Rad18 E3 ubiquitin ligase activity mediates Fanconi anemia pathway activation and cell survival following DNA Topoisomerase 1 inhibition

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Cell Cycle

• Publication date

  2011-05-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4161/cc.10.10.15617PMID 21478670PMCID PMC3127162
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The E3 ubiquitin ligase RAD18 regulates ubiquitylation and chromatin loading of FANCD2 and FANCI.

  2011cited by this paper
• The RAD6 DNA damage tolerance pathway operates uncoupled from the replication fork and is functional beyond S phase.

  2010cited by this paper
• Cellular processing determinants for the activation of damage signals in response to topoisomerase I-linked DNA breakage

  2010cited by this paper
• Phosphorylated Rad18 directs DNA Polymerase η to sites of stalled replication

  2010cited by this paper
• RAD18-mediated ubiquitination of PCNA activates the Fanconi anemia DNA repair network

  2010cited by this paper
• A novel role for fanconi anemia (FA) pathway effector protein FANCD2 in cell cycle progression of untransformed primary human cells

  2010cited by this paper
• Topoisomerase I suppresses genomic instability by preventing interference between replication and transcription

  2010cited by this paper
• Rad18-mediated Translesion Synthesis of Bulky DNA Adducts Is Coupled to Activation of the Fanconi Anemia DNA Repair Pathway*

  2010cited by this paper
• Ku70 Corrupts DNA Repair in the Absence of the Fanconi Anemia Pathway

  2010cited by this paper
• A genetic screen identifies FAN1, a Fanconi anemia-associated nuclease necessary for DNA interstrand crosslink repair.

  2010cited by this paper
• FANCJ/BRIP1 recruitment and regulation of FANCD2 in DNA damage responses

  2010cited by this paper
• Monoubiquitylation in the Fanconi anemia DNA damage response pathway.

  2009cited by this paper
• Differential Roles for DNA Polymerases Eta, Zeta, and REV1 in Lesion Bypass of Intrastrand versus Interstrand DNA Cross-Links

  2009cited by this paper
• How the fanconi anemia pathway guards the genome.

  2009cited by this paper
• Topoisomerase I suppresses genomic instability by preventing interference between replication and transcription

  2009cited by this paper
• FANCD2 hurdles the DNA interstrand crosslink.

  2009cited by this paper
• RAD18 transmits DNA damage signaling to elicit homologous recombination repair

  2009influential reference
• Selective accumulation of virus-specific CD8+ T cells within the peripheral blood stem cell compartment.

  2009cited by this paper
• Dynamic localization of human RAD18 during the cell cycle and a functional connection with DNA double-strand break repair.

  2009cited by this paper
• Impaired FANCD2 monoubiquitination and hypersensitivity to camptothecin uniquely characterize Fanconi anemia complementation group M.

  2009cited by this paper
• RAD18 promotes DNA double-strand break repair during G1 phase through chromatin retention of 53BP1

  2009cited by this paper
• DNA topoisomerase I inhibitors: chemistry, biology, and interfacial inhibition.

  2009cited by this paper
• Mechanistic insight into site-restricted monoubiquitination of FANCD2 by Ube2t, FANCL, and FANCI.

  2008cited by this paper
• Recognition of forked and single‐stranded DNA structures by human RAD18 complexed with RAD6B protein triggers its recruitment to stalled replication forks

  2008cited by this paper
• Activation of Ubiquitin-Dependent DNA Damage Bypass Is Mediated by Replication Protein A

  2008cited by this paper
• DNA Damage-induced Ubiquitylation of RFC2 Subunit of Replication Factor C Complex*

  2008cited by this paper
• Et al

  2008cited by this paper
• Regulation of proliferating cell nuclear antigen ubiquitination in mammalian cells

  2008influential reference
• Fanconi anemia proteins stabilize replication forks.

  2008cited by this paper
• UBE2T, the Fanconi Anemia Core Complex, and FANCD2 Are Recruited Independently to Chromatin: a Basis for the Regulation of FANCD2 Monoubiquitination

  2007cited by this paper
• RAD18 and Poly(ADP-Ribose) Polymerase Independently Suppress the Access of Nonhomologous End Joining to Double-Strand Breaks and Facilitate Homologous Recombination-Mediated Repair

  2007cited by this paper
• Human Mus81 and FANCB independently contribute to repair of DNA damage during replication

  2007cited by this paper
• Antitumour drugs impede DNA uncoiling by topoisomerase I

  2007influential reference
• Dormant origins licensed by excess Mcm2-7 are required for human cells to survive replicative stress.

  2007cited by this paper
• UBE2T is the E2 in the Fanconi anemia pathway and undergoes negative autoregulation.

  2006cited by this paper
• Topoisomerase I inhibitors: camptothecins and beyond

  2006influential reference
• Regulation of DNA repair by ubiquitylation

  2006cited by this paper
• Repair of topoisomerase I-mediated DNA damage.

  2006cited by this paper
• The Chk 1-mediated S-phase Checkpoint Targets Initiation Factor Cdc 45 via a Cdc 25 A / Cdk 2-independent Mechanism *

  2006cited by this paper
• Regulation of monoubiquitinated PCNA by DUB autocleavage

  2006cited by this paper
• The Chk1-mediated S-phase Checkpoint Targets Initiation Factor Cdc45 via a Cdc25A/Cdk2-independent Mechanism*

  2006cited by this paper
• Excess Mcm2–7 license dormant origins of replication that can be used under conditions of replicative stress

  2006cited by this paper
• Rad18 Regulates DNA Polymerase κ and Is Required for Recovery from S-Phase Checkpoint-Mediated Arrest

  2006cited by this paper
• Eukaryotic translesion synthesis DNA polymerases: specificity of structure and function.

  2005influential reference
• DNA Polymerase κ Is Specifically Required for Recovery from the Benzo[a]pyrene-Dihydrodiol Epoxide (BPDE)-induced S-phase Checkpoint*

  2005cited by this paper
• Regulated interaction of the Fanconi anemia protein, FANCD2, with chromatin.

  2005cited by this paper
• Fancd2 functions in a double strand break repair pathway that is distinct from non-homologous end joining.

  2005cited by this paper
• Multiple Endonucleases Function to Repair Covalent Topoisomerase I Complexes in Saccharomyces cerevisiae

  2005cited by this paper
• The deubiquitinating enzyme USP1 regulates the Fanconi anemia pathway.

  2005cited by this paper
• Human DNA topoisomerase I: relaxation, roles, and damage control

  2005cited by this paper
• Human Fanconi anemia monoubiquitination pathway promotes homologous DNA repair.

  2005influential reference
• Fancd 2 functions in a double strand break repair pathway that is distinct from non-homologous end joining

  2005cited by this paper
• Ubiquitination of PCNA and the Polymerase Switch in Human Cells

  2004influential reference
• Interaction of human DNA polymerase eta with monoubiquitinated PCNA: a possible mechanism for the polymerase switch in response to DNA damage.

  2004cited by this paper
• Structure, molecular mechanisms, and evolutionary relationships in DNA topoisomerases.

  2004cited by this paper
• Mechanisms of camptothecin resistance by human topoisomerase I mutations.

  2004cited by this paper
• Hydrogen Peroxide Induces Topoisomerase I-mediated DNA Damage and Cell Death*

  2004cited by this paper
• Rad18 guides polη to replication stalling sites through physical interaction and PCNA monoubiquitination

  2004cited by this paper
• Functional Interaction of Monoubiquitinated FANCD2 and BRCA2/FANCD1 in Chromatin

  2004cited by this paper
• Camptothecins and topoisomerase I: a foot in the door. Targeting the genome beyond topoisomerase I with camptothecins and novel anticancer drugs: importance of DNA replication, repair and cell cycle checkpoints.

  2004cited by this paper
• A novel ubiquitin ligase is deficient in Fanconi anemia

  2003cited by this paper
• Transcription-Dependent Degradation of Topoisomerase I-DNA Covalent Complexes

  2003cited by this paper
• Sensing DNA Damage Through ATRIP Recognition of RPA-ssDNA Complexes

  2003cited by this paper
• The DNA damage-dependent intra–S phase checkpoint is regulated by parallel pathways

  2002cited by this paper
• Cellular roles of DNA topoisomerases: a molecular perspective

  2002cited by this paper
• Cancer therapeutics in yeast.

  2002cited by this paper
• Tumor cell death induced by topoisomerase-targeting drugs.

  2001cited by this paper
• Cell Cycle-dependent Proteolysis and Phosphorylation of Human Mcm10*

  2001cited by this paper
• Bone Morphogenetic Protein-2 Inhibits Serum Deprivation-induced Apoptosis of Neonatal Cardiac Myocytes through Activation of the Smad1 Pathway*

  2001cited by this paper
• Conversion of Topoisomerase I Cleavage Complexes on the Leading Strand of Ribosomal DNA into 5′-Phosphorylated DNA Double-Strand Breaks by Replication Runoff

  2000influential reference
• A model for the mechanism of human topoisomerase I.

  1998influential reference
• Analysis of topoisomerase I/DNA complexes in patients administered topotecan.

  1995cited by this paper
• Topoisomerase-targeting antitumor drugs: mechanisms of cytotoxicity and resistance.

  1992influential reference
• Effects of camptothecin on the breakage and repair of DNA during the cell cycle.

  1973cited by this paper

• SMARCA4 regulates SMARCAD1 expression for toleration of replication stress in non-small cell lung cancer

  2025cites this paper
• Cell Type Specific Suppression of Hyper-Recombination by Human RAD18 Is Linked to Proliferating Cell Nuclear Antigen K164 Ubiquitination

  2025cites this paper
• PCNA-binding activity separates RNF168 functions in DNA replication and DNA double-stranded break signaling

  2024cites this paper
• Cell type specific suppression of hyper-recombination by human RAD18 is linked to PCNA K164 ubiquitination

  2024cites this paper
• Roles of trans-lesion synthesis (TLS) DNA polymerases in tumorigenesis and cancer therapy

  2023cites this paper
• A scalable platform for efficient CRISPR-Cas9 chemical-genetic screens of DNA damage-inducing compounds

  2023cites this paper
• RAD18 opposes transcription-associated genome instability through FANCD2 recruitment

  2022cites this paper
• Targeting CX3CR1 Suppresses the Fanconi Anemia DNA Repair Pathway and Synergizes with Platinum

  2021cites this paper
• Roles of RAD18 in DNA replication and post-replication repair (PRR)

  2021cites this paper
• A Degenerate PCNA-Interacting Peptide (DPIP) box targets RNF168 to replicating DNA to limit 53BP1 signaling

  2021cites this paper
• Rad18 mediates specific mutational signatures and shapes the genomic landscape of carcinogen-induced tumors in vivo

  2021cites this paper
• The forkhead box M1 (FOXM1) expression and antitumor effect of FOXM1 inhibition in malignant rhabdoid tumor

  2020cites this paper
• SET1/MLL family of proteins: functions beyond histone methylation

  2020cites this paper
• Mustard Seed (Brassica nigra) Extract Exhibits Antiproliferative Effect against Human Lung Cancer Cells through Differential Regulation of Apoptosis, Cell Cycle, Migration, and Invasion

  2020influential citation
• RAD18 may function as a predictor of response to preoperative concurrent chemoradiotherapy in patients with locally advanced rectal cancer through caspase‐9‐caspase‐3‐dependent apoptotic pathway

  2019cites this paper
• Synergistic Effects of Andrographolide on DNA Damage Repair Mechanism and Apoptosis in Breast Cancer Cells

  2019cites this paper
• Acetaldehyde forms covalent GG intrastrand crosslinks in DNA

  2019cites this paper
• Fanconi Anemia Signaling: The Role of FANCD2 During M Phase.

  2018cites this paper
• Regulation of various DNA repair pathways by E3 ubiquitin ligases

  2017cites this paper
• DNA repair factor RAD18 and DNA polymerase Pol κ confer tolerance of oncogenic DNA replication stress

  2017cites this paper
• RAD6 promotes DNA repair and stem cell signaling in ovarian cancer and is a promising therapeutic target to prevent and treat acquired chemoresistance

  2017cites this paper
• Fanconi Anemia Signaling and Cancer.

  2017cites this paper
• DNA repair factor RAD18 and DNA polymerase Polκ confer tolerance of oncogenic DNA replication stress

  2017cites this paper
• Common Chemical Inductors of Replication Stress: Focus on Cell-Based Studies

  2017cites this paper
• The Crossroads of Ubiquitination and DNA Repair: A Structural Perspective

  2016cites this paper
• A novel role for non-ubiquitinated FANCD2 in response to hydroxyurea-induced DNA damage

  2016cites this paper
• Rad18 is required for functional interactions between FANCD2, BRCA2, and Rad51 to repair DNA topoisomerase 1-poisons induced lesions and promote fork recovery

  2016influential citation
• Mgm101: A double-duty Rad52-like protein

  2016cites this paper
• Rad18 confers hematopoietic progenitor cell DNA damage tolerance independently of the Fanconi Anemia pathway in vivo

  2016influential citation
• USP7 is essential for maintaining Rad18 stability and DNA damage tolerance

  2016cites this paper
• A neomorphic cancer cell-specific role of MAGE-A4 in trans-lesion synthesis

  2016cites this paper
• Synthesis and in vitro anticancer evaluation of some 4,6-diamino-1,3,5-triazine-2-carbohydrazides as Rad6 ubiquitin conjugating enzyme inhibitors.

  2016cites this paper
• Rad6 upregulation promotes stem cell-like characteristics and platinum resistance in ovarian cancer.

  2016cites this paper
• Roles of RAD18 in DNA Replication and Postreplication Repair

  2016cites this paper
• Functional interaction between the DNA damage tolerance pathway and the DNA damage checkpoint : implications for genome stability and oncogenesis

  2016influential citation
• Tumor suppressor miR-145 reverses drug resistance by directly targeting DNA damage-related gene RAD18 in colorectal cancer

  2015cites this paper
• Regulation of Y-family translesion synthesis ( TLS ) DNA polymerases by RAD 18

  2015cites this paper
• Allyl isothiocyanate induces replication-associated DNA damage response in NSCLC cells and sensitizes to ionizing radiation

  2015cites this paper
• FANCD2 and REV1 cooperate in the protection of nascent DNA strands in response to replication stress

  2015influential citation
• FANCJ protein is important for the stability of FANCD2/FANCI proteins and protects them from proteasome and caspase-3 dependent degradation

  2015cites this paper
• Discrimination of Kinetic Models by a Combination of Microirradiation and Fluorescence Photobleaching.

  2015cites this paper
• RNA interferences targeting the Fanconi anemia/BRCA pathway upstream genes reverse cisplatin resistance in drug-resistant lung cancer cells

  2015cites this paper
• Rad18 and Rnf8 facilitate homologous recombination by two distinct mechanisms, promoting Rad51 focus formation and suppressing the toxic effect of nonhomologous end joining

  2014cites this paper
• ALDH1A1 Maintains Ovarian Cancer Stem Cell-Like Properties by Altered Regulation of Cell Cycle Checkpoint and DNA Repair Network Signaling

  2014cites this paper
• The Rad6/18 Ubiquitin Complex Interacts with the Epstein-Barr Virus Deubiquitinating Enzyme, BPLF1, and Contributes to Virus Infectivity

  2014cites this paper
• The Fanconi anemia ID2 complex: Dueling saxes at the crossroads

  2014cites this paper
• Gli1 Protein Regulates the S-phase Checkpoint in Tumor Cells via Bid Protein, and Its Inhibition Sensitizes to DNA Topoisomerase 1 Inhibitors*

  2014influential citation
• Quantitative proteomics of human chromatin

  2013cites this paper
• Cell cycle stage-specific roles of Rad18 in tolerance and repair of oxidative DNA damage

  2013cites this paper
• Readers of PCNA modifications

  2013influential citation
• Regulation of DNA cross-link repair by the Fanconi anemia/BRCA pathway.

  2012cites this paper
• Epstein-Barr Virus BPLF1 Deubiquitinates PCNA and Attenuates Polymerase η Recruitment to DNA Damage Sites

  2012cites this paper
• A prototypical Fanconi anemia pathway in lower eukaryotes?

  2012cites this paper
• DNA repair and resistance to topoisomerase I inhibitors: mechanisms, biomarkers and therapeutic targets.

  2012cites this paper
• c-Jun N-terminal kinase–mediated Rad18 phosphorylation facilitates Polη recruitment to stalled replication forks

  2012cites this paper
• Ubiquitin-activating enzyme UBA1 is required for cellular response to DNA damage

  2012influential citation
• Rad18 is a transcriptional target of E2F3

  2012cites this paper
• REV1 and DNA polymerase zeta in DNA interstrand crosslink repair

  2012cites this paper
• Rescue of replication failure by Fanconi anaemia proteins

  2011cites this paper
• Rad18 emerges as a critical regulator of the Fanconi anemia pathway

  2011cites this paper
• Zinc, a promising mineral for misfolded p53 reactivation

  2011cites this paper
• A novel Rad18 ubiqitin ligase-mediated pathway for repair of camptothecin-induced DNA damage

  2011cites this paper
• Human RAD18 Interacts with Ubiquitylated Chromatin Components and Facilitates RAD9 Recruitment to DNA Double Strand Breaks

  2011cites this paper
• Regulation of Rev1 by the Fanconi Anemia Core Complex

  2011cites this paper