A Tat subunit vaccine confers protective immunity against the immune-modulating activity of the human immunodeficiency virus type-1 Tat protein in mice

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Proceedings of the National Academy of Sciences of the United States of America

• Publication date

  2002-07-02

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1073/pnas.152313899PMID 12096189PMCID PMC126620
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2001cited by this paper
• Vaccination with DNA containing tat coding sequences and unmethylated CpG motifs protects cynomolgus monkeys upon infection with simian/human immunodeficiency virus (SHIV89.6P).

  2001cited by this paper
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  2000cited by this paper
• HIV‐1 Tat mutants in the cysteine‐rich region downregulate HLA class II expression in T lymphocytic and macrophage cell lines

  2000cited by this paper
• Impaired function of circulating HIV-specific CD8(+) T cells in chronic human immunodeficiency virus infection.

  2000cited by this paper
• HIV-Specific Cd8+ T Cells Produce Antiviral Cytokines but Are Impaired in Cytolytic Function

  2000cited by this paper
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  2000cited by this paper
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  1999cited by this paper
• Tat as one key to HIV-induced immune pathogenesis and Tat (correction of Pat) toxoid as an important component of a vaccine.

  1999cited by this paper
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  1999cited by this paper
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  1999cited by this paper
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  1999cited by this paper
• Extracellular HIV-1 tat protein up-regulates the expression of surface CXC-chemokine receptor 4 in resting CD4+ T cells.

  1999cited by this paper
• Tat as one key to HIV-induced immune pathogenesis and Pat toxoid as an important component of a vaccine

  1999cited by this paper
• Interferon alpha and Tat involvement in the immunosuppression of uninfected T cells and C-C chemokine decline in AIDS.

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• Identification of a Novel Domain of HIV Tat Involved in Monocyte Chemotaxis*

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  1998cited by this paper
• HIV-1 Tat protein mimicry of chemokines.

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• Extracellular HIV‐1 Tat protein activates phosphatidylinositol 3‐ and Akt/PKB kinases in CD4+ T lymphoblastoid Jurkat cells

  1997cited by this paper
• Dual role of HIV Tat in regulation of apoptosis in T cells.

  1997cited by this paper
• CD8+ T cell‐mediated suppression of HIV long terminal repeat‐driven gene expression is not associated with improved clinical status

  1997cited by this paper
• HIV‐1 Tat protein exits from cells via a leaderless secretory pathway and binds to extracellular matrix‐associated heparan sulfate proteoglycans through its basic region

  1997cited by this paper
• Tat-mediated protein delivery can facilitate MHC class I presentation of antigens

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  1996cited by this paper
• CD26 mediates the action of HIV-1 Tat protein on DNA synthesis and cytokine production in U937 cells.

  1996cited by this paper
• Pleiotropic effects of immobilized versus soluble recombinant HIV-1 Tat protein on CD3-mediated activation, induction of apoptosis, and HIV-1 long terminal repeat transactivation in purified CD4+ T lymphocytes.

  1996cited by this paper
• Antibody against human immunodeficiency virus type 1 (HIV-1) Tat protein may have influenced the progression of AIDS in HIV-1-infected hemophiliac patients

  1996cited by this paper
• Effect of antibody to HIV-1 Tat protein on viral replication in vitro and progression of HIV-1 disease in vivo.

  1995cited by this paper
• Failure of T-cell homeostasis preceding AIDS in HIV-1 infection

  1995cited by this paper
• Induction of apoptosis in uninfected lymphocytes by HIV-1 Tat protein.

  1995cited by this paper
• Quantification of antigen specific CD8+ T cells using an ELISPOT assay.

  1995cited by this paper
• The human immunodeficiency virus type-1 Tat protein upregulates Bcl-2 gene expression in Jurkat T-cell lines and primary peripheral blood mononuclear cells.

  1995cited by this paper
• An autocrine loop of HIV type-1 Tat protein responsible for the improved survival/proliferation capacity of permanently Tat-transfected cells and required for optimal HIV-1 LTR transactivating activity.

  1995cited by this paper
• Epitope Mapping and Topology of Baculovirus-Expressed HIV-1 gp160 Determined with a Panel of Murine Monoclonal Antibodies

  1994cited by this paper
• Tat-mediated delivery of heterologous proteins into cells.

  1994cited by this paper
• Release, uptake, and effects of extracellular human immunodeficiency virus type 1 Tat protein on cell growth and viral transactivation

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• Detection of replication-competent and pseudotyped human immunodeficiency virus with a sensitive cell line on the basis of activation of an integrated beta-galactosidase gene

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• β2-Microglobulin deficient mice lack CD4−8+ cytolytic T cells

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• Tat protein of HIV-1 stimulates growth of cells derived from Kaposi's sarcoma lesions of AIDS patients

  1990cited by this paper
• Direct gene transfer into mouse muscle in vivo.

  1990cited by this paper
• Inhibition of antigen-induced lymphocyte proliferation by Tat protein from HIV-1.

  1989cited by this paper
• An immunodominant epitope of the human immunodeficiency virus envelope glycoprotein gp160 recognized by class I major histocompatibility complex molecule-restricted murine cytotoxic T lymphocytes.

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