The synthetic somatostatin analogue, octreotide, ameliorates acute and delayed intestinal radiation injury.

No abstract is available for this paper.

• Publication year

  1999

• Venue

  International Journal of Radiation Oncology, Biology, Physics

• Publication date

  1999-12-01

• Fields of study

  Medicine, Environmental Science

• Identifiers
  DOI 10.1016/S0360-3016(99)00293-XPMID 10613325
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Octreotide

  2025cited by this paper
• Octreotide for nausea and vomiting after chemotherapy and stem-cell transplantation.

  1999cited by this paper
• The effect of intestinal permeability on pancreatic enzyme-induced enteropathy in the rat.

  1998cited by this paper
• Characterization of Protease-activated Receptor-2 Immunoreactivity in Normal Human Tissues

  1998cited by this paper
• Indomethacin and Pancreatic Enzymes Synergistically Damage Intestine of Rats

  1998cited by this paper
• The correlation of acute toxicity and late rectal injury in radiotherapy for cervical carcinoma: evidence suggestive of consequential late effect (CQLE).

  1998cited by this paper
• Antidiarrheal agents for the management of treatment-related diarrhea in cancer patients.

  1998cited by this paper
• Proteinase-activated receptors: novel mechanisms of signaling by serine proteases.

  1998cited by this paper
• Recommended guidelines for the treatment of chemotherapy-induced diarrhea.

  1998cited by this paper
• Increased transforming growth factor beta (TGF-beta) immunoreactivity is independently associated with chronic injury in both consequential and primary radiation enteropathy.

  1997cited by this paper
• Association of granulocyte transmigration with structural and cellular parameters of injury in experimental radiation enteropathy.

  1997cited by this paper
• Relationship between intestinal fibrosis and histopathologic and morphometric changes in consequential and late radiation enteropathy.

  1996cited by this paper
• Octreotide.

  1996cited by this paper
• Models for estimating the risk of ulcers in the small intestine after localized single or fractionated irradiation.

  1995cited by this paper
• Somatostatin and somatostatin analogues: pharmacokinetics and pharmacodynamic effects.

  1994cited by this paper
• Significance of overall treatment time for the development of radiation‐induced intestinal complications. An experimental study in the rat

  1994cited by this paper
• Strictures of ascending colon in cystic fibrosis and high-strength pancreatic enzymes.

  1994cited by this paper
• Nitric oxide synthesis inhibition increases epithelial permeability via mast cells.

  1994cited by this paper
• Postreceptor signal transduction mechanisms involved in octreotide-induced inhibition of angiogenesis.

  1994cited by this paper
• Faecal calprotectin: a novel test for the diagnosis of colorectal cancer?

  1993cited by this paper
• Histological changes in mouse colon after single- and split-dose irradiation.

  1993cited by this paper
• Tolerance of rat small intestine to localized single dose and fractionated irradiation.

  1992cited by this paper
• Antiproliferative effects of the somatostatin analogue octreotide (SMS 201-995) on ZR-75-1 human breast cancer cells in vivo and in vitro.

  1992cited by this paper
• Assessment of the neutrophil dominating protein calprotectin in feces. A methodologic study.

  1992cited by this paper
• Preclinical studies on the anticancer activity of the somatostatin analogue octreotide (SMS 201-995).

  1992cited by this paper
• Effects of SMS 201-995 on basal and stimulated pancreatic secretion in rats.

  1990cited by this paper
• Late radiation injury of the small intestine. Clinical, pathophysiologic and radiobiologic aspects. A review.

  1990cited by this paper
• Effects of accelerated fractionation on radiation injury of the small intestine: a new rat model.

  1988cited by this paper
• Accelerated fractionation in the radiation treatment of head and neck cancer. A critical comparison of different strategies.

  1988cited by this paper
• Collagen content and types in the intestinal strictures of Crohn's disease.

  1988cited by this paper
• Assay of premorbid murine jejunal fibrosis based on mechanical changes after X irradiation and hyperthermia.

  1987cited by this paper
• Collagen synthesis by human intestinal smooth muscle cells in culture.

  1987cited by this paper
• Experimental studies on the pathogenesis of the chronic radiation ulcer of the large bowel in rats.

  1986cited by this paper
• Estimation of surface area from vertical sections

  1986cited by this paper
• Influence of pancreatic secretion on late radiation enteropathy in the rat.

  1985cited by this paper
• Quantitative changes in the goblet cells of the rat small intestine after irradiation.

  1985cited by this paper
• The role of luminal contents in radiation enteritis

  1984cited by this paper
• Effects of dose fractionation on late roentgen radiation damage of rat small intestine.

  1983cited by this paper
• Late changes following single dose roentgen irradiation of rat small intestine.

  1983cited by this paper
• The relationship between early and late gastrointestinal complications of radiation therapy for carcinoma of the cervix.

  1983cited by this paper
• Radiation injury in surgical pathology: Part II. Alimentary tract

  1981cited by this paper
• Radiation injury in surgical pathology: Part 1

  1978cited by this paper
• Aseptic endotoxemia in radiation injury and graft-vs-host diesease.

  1975cited by this paper
• Prolongation of survival in lethally irradiated dogs by pancreatic duct ligation.

  1970cited by this paper
• Injurious effect of pancreatic secretions on postradiation enteropathy.

  1967cited by this paper
• PROTECTION AGAINST LETHAL IRRADIATION INJURY BY PANCREATIC ENZYME EXCLUSION.

  1967cited by this paper
• Influence of Intestinal Content on Radiation Lesions of the Small Intestine,∗

  1967cited by this paper
• The nature of intestinal radiation death.

  1956cited by this paper

• The delayed effects of acute radiation exposure (DEARE): characteristics, mechanisms, animal models, and promising medical countermeasures

  2023cites this paper
• High-throughput screening strategies for space-based radiation countermeasure discovery.

  2022cites this paper
• Nuclear and Radiological Emergencies: Biological Effects, Countermeasures and Biodosimetry

  2022cites this paper
• Radioprotection and Radiomitigation: From the Bench to Clinical Practice

  2020cites this paper
• Dietary Oat Bran Reduces Systemic Inflammation in Mice Subjected to Pelvic Irradiation

  2020cites this paper
• Pancreatic radiation effect in apoptosis-related rectal radiation toxicity

  2018cites this paper
• Role of drugs in the prevention and amelioration of radiation induced toxic effects

  2018cites this paper
• Pharmacological interventions for the prevention and treatment of radiation colitis, enteritis and proctitis

  2017cites this paper
• Low dose radiation exposure and cardiovascular diseases: a review

  2017cites this paper
• Strategies to Enhance the Therapeutic Ratio of Radiation as a Cancer Treatment

  2016cites this paper
• Novel Strategies to Prevent, Mitigate or Reverse Radiation Injury and Fibrosis

  2016cites this paper
• Protective role of hemeoxygenase-1 in gastrointestinal diseases

  2015cites this paper
• Optimising the management of gastrointestinal symptoms following pelvic radiotherapy.

  2014cites this paper
• Systematic review: the efficacy of nutritional interventions to counteract acute gastrointestinal toxicity during therapeutic pelvic radiotherapy

  2013cites this paper
• Gamma tocotrienol, a potent radioprotector, preferentially upregulates expression of anti-apoptotic genes to promote intestinal cell survival.

  2013cites this paper
• Pharmaceutical drugs supporting regeneration of small-intestinal mucosa severely damaged by ionizing radiation in mice

  2013cites this paper
• Effect of the new synthetic vitamin E derivative ETS-GS on radiation enterocolitis symptoms in a rat model

  2013cites this paper
• Amelioration of radiation-induced hematopoietic and gastrointestinal damage by Ex-RAD® in mice

  2012cites this paper
• TheProtectiveEffectofAmifostineonRadiation-Induced Proctitis:SystemicVersusTopicalApplication

  2012cites this paper
• Clinical trial: Efficacy of a low or modified fat diet for the prevention of gastrointestinal toxicity in patients receiving radiotherapy treatment for pelvic malignancies.

  2012cites this paper
• Novel drugs to ameliorate gastrointestinal normal tissue radiation toxicity in clinical practice: what is emerging from the laboratory?

  2012cites this paper
• Traitement des lésions colorectales radio-induites par injection de Cellules Stromales Mésenchymateuses (CSM) : implication du processus inflammatoire

  2012cites this paper
• ICRP PUBLICATION 118: ICRP Statement on Tissue Reactions and Early and Late Effects of Radiation in Normal Tissues and Organs — Threshold Doses for Tissue Reactions in a Radiation Protection Context

  2012cites this paper
• The Protective Effect of Amifostine on Radiation-Induced Proctitis: Systemic Versus Topical Application

  2011cites this paper
• Novel pharmacological strategies to reduce acute radiation injury

  2011cites this paper
• Protective Effects of Melatonin and Octreotide Against Radiation-Induced Intestinal Injury

  2011cites this paper
• Preclinical Evaluation of SOM230 as a Radiation Mitigator in a Mouse Model: Postexposure Time Window and Mechanisms of Action

  2011cites this paper
• Manipulating the consequential effect: an alternative approach to reducing pelvic radiation disease other than dose reduction.

  2011cites this paper
• Diarrhea and the rationale to use Sandostatin.

  2010cites this paper
• Protein-Losing Enteropathies

  2010cites this paper
• Gastrointestinal , Hepatobiliary and Pancreatic Pathology Essential Role of Plasminogen Activator Inhibitor Type-1 in Radiation Enteropathy

  2010cites this paper
• The Somatostatin Analog SOM230 (Pasireotide) Ameliorates Injury of the Intestinal Mucosa and Increases Survival after Total-Body Irradiation by Inhibiting Exocrine Pancreatic Secretion

  2009cites this paper
• Inactivation of Thrombomodulin by Ionizing Radiation in a Cell-Free System: Possible Implications for Radiation Responses in Vascular Endothelium

  2008cites this paper
• Medical Countermeasures for Radiation Combined Injury: Radiation with Burn, Blast, Trauma and/or Sepsis. Report of an NIAID Workshop, March 26–27, 2007

  2008cites this paper
• Medical prevention and treatment of acute and chronic radiation induced enteritis--is there any proven therapy? a short review.

  2008cites this paper
• Rôle de l’endothélium dans les dommages radio-induits aux tissus sains

  2008cites this paper
• The effect of simultaneous local irradiation of pancreas and rectum on radiation-induced rectal toxicity: Apoptosis and fibrosis

  2008cites this paper
• Medical Prevention and Treatment of Acute and Chronic Radiation Induced Enteritis - Is there any Proven Therapy? A short Review.

  2008cites this paper
• Essential role of plasminogen activator inhibitor type-1 in radiation enteropathy.

  2008cites this paper
• Glucagon-like peptide-2 improves both acute and late experimental radiation enteritis in the rat.

  2007cites this paper
• Effect of heme oxygenase‐1 induction by octreotide on TNBS‐induced colitis

  2007cites this paper
• Octreotide in the Management of Chemoradiotherapy-Induced Diarrhea Refractory to Loperamide in Patients with Rectal Carcinoma

  2007cites this paper
• Radiation damage to the gastrointestinal tract: mechanisms, diagnosis, and management

  2007cites this paper
• Simvastatin ameliorates radiation enteropathy development after localized, fractionated irradiation by a protein C-independent mechanism.

  2007cites this paper
• Activation of somatostatin receptors attenuates pulmonary fibrosis

  2007influential citation
• Increased uptake of 111In-octreotide in idiopathic pulmonary fibrosis.

  2006cites this paper
• The effect of heme oxygenase-1 induction by octreotide on radiation enteritis.

  2006influential citation
• The Effect of Octreotide on Pancreatic Damage in TNBS-Induced Colitis

  2006cites this paper
• Increased Uptake of 111 In-Octreotide in Idiopathic Pulmonary Fibrosis

  2006cites this paper
• Early and Late Treatment-Induced Toxicity

  2006cites this paper
• The Efficacy of Octreotide in Pancreatic and Intestinal Changes: Radiation-Induced Enteritis in Animals

  2006cites this paper
• Sucralfate does not ameliorate acute radiation proctitis: randomised study and meta-analysis.

  2005cites this paper
• Gastrointestinal mucositis.

  2004cites this paper
• Clinical practice guidelines for the prevention and treatment of cancer therapy–induced oral and gastrointestinal mucositis

  2004cites this paper
• Mechanisms and Modification of the Radiation Response of Gastrointestinal Organs

  2003cites this paper
• Up-regulation and Activation of Proteinase-Activated Receptor 2 in Early and Delayed Radiation Injury in the Rat Intestine: Influence of Biological Activators of Proteinase-Activated Receptor 2

  2003cites this paper
• Bowel injury: current and evolving management strategies.

  2003cites this paper
• Radiation toxicity and proteinase‐activated receptors

  2003cites this paper
• Review article The radiotherapeutic injury - a complex 'wound'

  2002cites this paper
• The efficacy of octreotide in the therapy of acute radiation-induced diarrhea: a randomized controlled study.

  2002cites this paper
• The dose-volume realationship of acute small bowel toxicity from concurrent 5-FU-based chemotherapy and radiation therapy for rectal cancer

  2002cites this paper
• The radiotherapeutic injury--a complex 'wound'.

  2002cites this paper
• The dose-volume relationship of acute small bowel toxicity from concurrent 5-FU-based chemotherapy and radiation therapy for rectal cancer.

  2002cites this paper
• Does sucralfate reduce early side effects of pelvic radiation? A double-blind randomized trial.

  2002cites this paper
• Clinical applications of radioprotectors

  2001cites this paper
• Influence of Short-Term Octreotide Administration on Chronic Tissue Injury, Transforming Growth Factor beta (TGF-beta) Overexpression, and Collagen Accumulation in Irradiated Rat Intestine.

  2001cites this paper
• Effects of radiation damage on intestinal morphology.

  2001cites this paper
• Influence of Short-Term Octreotide Administration on Chronic Tissue Injury , Transforming Growth Factor b ( TGF-b ) Overexpression , and Collagen Accumulation in Irradiated Rat

  2001cites this paper
• Consequential late effects in normal tissues.

  2001cites this paper
• Sensitizers and protectors of radiation and chemotherapy.

  2001cites this paper
• Radiation-induced granulocyte transmigration predicts development of delayed structural changes in rat intestine.

  2001cites this paper
• Role of Mast Cells in Early and Delayed Radiation Injury in Rat Intestine

  2000cites this paper