Peripherally derived FGF21 promotes remyelination in the central nervous system.

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Journal of Clinical Investigation

• Publication date

  2017-08-21

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1172/JCI94337PMID 28825598PMCID PMC5669554
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2013cited by this paper
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  2013cited by this paper
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  2013cited by this paper
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  2013cited by this paper
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  2013cited by this paper
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  2012cited by this paper
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  2012cited by this paper
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  2012cited by this paper
• Exogenous Leukemia Inhibitory Factor Stimulates Oligodendrocyte Progenitor Cell Proliferation and Enhances Hippocampal Remyelination

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  2012cited by this paper
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  2012cited by this paper
• The ageing systemic milieu negatively regulates neurogenesis and cognitive function

  2011cited by this paper
• FGF-dependent regulation of VEGF receptor 2 expression in mice.

  2011cited by this paper
• Vascular Endothelial Growth Factor Regulates the Migration of Oligodendrocyte Precursor Cells

  2011cited by this paper
• The aging systemic milieu negatively regulates neurogenesis and cognitive function

  2011cited by this paper
• Fibroblast Growth Factor 21 (FGF21) in Human Cerebrospinal Fluid

  2011cited by this paper
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  2011cited by this paper
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  2011cited by this paper
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  2011cited by this paper
• NF449 Is a Novel Inhibitor of Fibroblast Growth Factor Receptor 3 (FGFR3) Signaling Active in Chondrocytes and Multiple Myeloma Cells*

  2010influential reference
• White matter damage and cognitive impairment after traumatic brain injury

  2010cited by this paper
• Research resource: Comprehensive expression atlas of the fibroblast growth factor system in adult mouse.

  2010cited by this paper
• Multiple myeloma phosphotyrosine proteomic profile associated with FGFR3 expression, ligand activation, and drug inhibition

  2009influential reference
• An Oligovascular Niche: Cerebral Endothelial Cells Promote the Survival and Proliferation of Oligodendrocyte Precursor Cells

  2009cited by this paper
• The role of CNS glia in preserving axon function.

  2009cited by this paper
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  2009cited by this paper
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  2009cited by this paper
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  2009cited by this paper
• Cognitive impairment in multiple sclerosis.

  2008cited by this paper
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  2008cited by this paper
• Remyelination in the CNS: from biology to therapy

  2008cited by this paper
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  2008cited by this paper
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  2008cited by this paper
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  2007cited by this paper
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  2007cited by this paper
• The fasting polypeptide FGF21 can enter brain from blood.

  2007influential reference
• Can regenerating axons recapitulate developmental guidance during recovery from spinal cord injury?

  2006cited by this paper
• Blood–brain Barrier: Structural Components and Function Under Physiologic and Pathologic Conditions

  2006cited by this paper
• Distinct Fibroblast Growth Factor (FGF)/FGF Receptor Signaling Pairs Initiate Diverse Cellular Responses in the Oligodendrocyte Lineage

  2005cited by this paper
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  2005cited by this paper
• Novel Role of Vitamin K in Preventing Oxidative Injury to Developing Oligodendrocytes and Neurons

  2003cited by this paper
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  2003cited by this paper
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  2003cited by this paper
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  2002cited by this paper
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  2002cited by this paper
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  2000cited by this paper
• PDGF and FGF-2 signaling in oligodendrocyte progenitor cells: regulation of proliferation and differentiation by multiple intracellular signaling pathways.

  2000cited by this paper
• Oligodendrocyte progenitors are present in the normal adult human CNS and in the lesions of multiple sclerosis.

  1998cited by this paper
• In vivo proliferation of oligodendrocyte progenitors expressing PDGFalphaR during early remyelination.

  1998cited by this paper
• Locomotor deficits induced by experimental spinal cord demyelination are abolished by spontaneous remyelination.

  1997cited by this paper
• In situ expression of fibroblast growth factor receptors by oligodendrocyte progenitors and oligodendrocytes in adult mouse central nervous system

  1997cited by this paper
• Regulation of FGF receptors in the oligodendrocyte lineage.

  1996cited by this paper
• Blood-brain barrier breach following cortical contusion in the rat.

  1996cited by this paper
• Cerebrovascular Permeability to Peptides: Manipulations of Transport Systems at the Blood-Brain Barrier

  1995influential reference
• Blood-brain barrier permeability, cerebral edema, and neurologic function after closed head injury in rats.

  1993cited by this paper
• Blood-brain barrier permeability to horseradish peroxidase in twitcher and cuprizone-intoxicated mice.

  1987cited by this paper
• Central remyelination restores secure conduction

  1979cited by this paper

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  2026cites this paper
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  2025cites this paper
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  2025cites this paper
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  2025cites this paper
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  2024cites this paper
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  2023cites this paper
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  2023cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2019cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2017cites this paper
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