Control of cardiac ryanodine receptor by sarcoplasmic reticulum luminal Ca2+

Jones et al. propose that SR luminal Ca2+ regulates RyR2 activity via a luminal Ca2+ sensor distinct from the cytosolic Ca2+ sensor.

• Publication year

  2017

• Venue

  The Journal of General Physiology

• Publication date

  2017-09-04

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1085/jgp.201711805PMID 28798281PMCID 5583710
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• FKBPs facilitate the termination of spontaneous Ca2+ release in wild-type RyR2 but not CPVT mutant RyR2.

  2016cited by this paper
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  2016cited by this paper
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  2016influential reference
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• Structural Basis for Gating and Activation of RyR1.

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  2016influential reference
• The EF-hand Ca2+ Binding Domain Is Not Required for Cytosolic Ca2+ Activation of the Cardiac Ryanodine Receptor*

  2015cited by this paper
• Oxidation of ryanodine receptor (RyR) and calmodulin enhance Ca release and pathologically alter, RyR structure and calmodulin affinity.

  2015cited by this paper
• Arrhythmogenesis in a catecholaminergic polymorphic ventricular tachycardia mutation that depresses ryanodine receptor function

  2015cited by this paper
• The arrhythmogenic human HRC point mutation S96A leads to spontaneous Ca(2+) release due to an impaired ability to buffer store Ca(2+).

  2014cited by this paper
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  2014cited by this paper
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  2014cited by this paper
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  2014cited by this paper
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  2014cited by this paper
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  2013cited by this paper
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  2013cited by this paper
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  2012influential reference
• Abnormal Termination of Ca2+ Release Is a Common Defect of RyR2 Mutations Associated With Cardiomyopathies

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• Cardiac calsequestrin: quest inside the SR

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  2008cited by this paper
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  2007cited by this paper
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  2007cited by this paper
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  2007cited by this paper
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  2007cited by this paper
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  2007cited by this paper
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  2007cited by this paper
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  2007influential reference
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  2006cited by this paper
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  2004cited by this paper
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  2004cited by this paper
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  2004cited by this paper
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  2003cited by this paper
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  2002cited by this paper
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  2002cited by this paper
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  2002cited by this paper
• Light at the end of the Ca2+-release channel tunnel: structures and mechanisms involved in ion translocation in ryanodine receptor channels

  2001cited by this paper
• PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts.

  2000cited by this paper
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  1998cited by this paper
• Activation of the cardiac calcium release channel (ryanodine receptor) by poly-S-nitrosylation.

  1998cited by this paper
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  1997cited by this paper
• Sarcoplasmic reticulum lumenal Ca2+ has access to cytosolic activation and inactivation sites of skeletal muscle Ca2+ release channel.

  1996cited by this paper
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  1995cited by this paper

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