Comparative 13C Metabolic Flux Analysis of Pyruvate Dehydrogenase Complex-Deficient, l-Valine-Producing Corynebacterium glutamicum

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Applied and Environmental Microbiology

• Publication date

  2011-07-22

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1128/AEM.00575-11PMID 21784914PMCID PMC3187166
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• 13C-based metabolic flux analysis

  2012cited by this paper
• Stationary versus non-stationary (13)C-MFA: a comparison using a consistent dataset.

  2011cited by this paper
• Studies on substrate utilisation in l-valine-producing Corynebacterium glutamicum strains deficient in pyruvate dehydrogenase complex

  2010cited by this paper
• Analysing overexpression of l-valine biosynthesis genes in pyruvate-dehydrogenase-deficient Corynebacterium glutamicum

  2010cited by this paper
• The identification of enzyme targets for the optimization of a valine producing Corynebacterium glutamicum strain using a kinetic model

  2009cited by this paper
• 13C-based metabolic flux analysis

  2009cited by this paper
• Fermentative production of branched chain amino acids: a focus on metabolic engineering

  2009cited by this paper
• Increased Glucose Utilization in Corynebacterium glutamicum by Use of Maltose, and Its Application for the Improvement of l-Valine Productivity

  2009cited by this paper
• Importance of NADPH supply for improved L‐valine formation in Corynebacterium glutamicum

  2009cited by this paper
• Corynebacterium glutamicum tailored for high-yield L-valine production

  2008cited by this paper
• Analysis of amino acids without derivatization in barley extracts by LC-MS-MS

  2008cited by this paper
• Influence of l-isoleucine and pantothenate auxotrophy for l-valine formation in Corynebacterium glutamicum revisited by metabolome analyses

  2008cited by this paper
• Expression of the Escherichia coli pntAB genes encoding a membrane-bound transhydrogenase in Corynebacterium glutamicum improves l-lysine formation

  2007cited by this paper
• Metabolic engineering of Escherichia coli for the production of l-valine based on transcriptome analysis and in silico gene knockout simulation

  2007cited by this paper
• l-Valine Production with Pyruvate Dehydrogenase Complex-Deficient Corynebacterium glutamicum

  2007cited by this paper
• Metabolic flux analysis at ultra short time scale: isotopically non-stationary 13C labeling experiments.

  2007cited by this paper
• l-Valine biosynthesis during batch and fed-batch cultivations of Corynebacterium glutamicum: Relationship between changes in bacterial growth rate and intracellular metabolism

  2007cited by this paper
• Simultaneous determination of multiple intracellular metabolites in glycolysis, pentose phosphate pathway and tricarboxylic acid cycle by liquid chromatography-mass spectrometry.

  2007cited by this paper
• Basic Biotechnology: Amino acids

  2006cited by this paper
• Lysine and glutamate production by Corynebacterium glutamicum on glucose, fructose and sucrose: roles of malic enzyme and fructose-1,6-bisphosphatase.

  2005cited by this paper
• Global metabolite analysis of yeast: evaluation of sample preparation methods

  2005cited by this paper
• Feedback-Resistant Acetohydroxy Acid Synthase Increases Valine Production in Corynebacterium glutamicum

  2005cited by this paper
• Pyruvate:Quinone Oxidoreductase from Corynebacterium glutamicum: Purification and Biochemical Characterization

  2005cited by this paper
• Comparative Metabolic Flux Analysis of Lysine-Producing Corynebacterium glutamicum Cultured on Glucose or Fructose

  2004cited by this paper
• Carbon Flux Analysis in a Pantothenate Overproducing Corynebacterium Glutamicum Strain

  2004cited by this paper
• Proton translocation by transhydrogenase

  2003influential reference
• Linking Central Metabolism with Increased Pathway Flux: l-Valine Accumulation by Corynebacterium glutamicum

  2002cited by this paper
• Changes of pentose phosphate pathway flux in vivo in Corynebacterium glutamicum during leucine-limited batch cultivation as determined from intracellular metabolite concentration measurements.

  2002cited by this paper
• 13C metabolic flux analysis.

  2001cited by this paper
• Bidirectional reaction steps in metabolic networks: IV. Optimal design of isotopomer labeling experiments.

  1999cited by this paper
• Bidirectional reaction steps in metabolic networks: III. Explicit solution and analysis of isotopomer labeling systems.

  1999cited by this paper
• Response of the central metabolism in Corynebacterium glutamicum to the use of an NADH-dependent glutamate dehydrogenase.

  1999cited by this paper
• Response of the central metabolism of Corynebacterium glutamicum to different flux burdens.

  1997cited by this paper
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  1997cited by this paper
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  1997cited by this paper
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  1996cited by this paper
• Cloning, sequence analysis, expression, and inactivation of the Corynebacterium glutamicum icd gene encoding isocitrate dehydrogenase and biochemical characterization of the enzyme

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• A method for the determination of changes of glycolytic metabolites in yeast on a subsecond time scale using extraction at neutral pH.

  1992cited by this paper
• Amplification of three threonine biosynthesis genes inCorynebacterium glutamicum and its influence on carbon flux in different strains

  1991cited by this paper
• Amino acids

  1916cited by this paper

• Model predictive control with supervisory substrate targeting for multi-setpoint biomass control in continuous bioprocesses

  2026cites this paper
• Multi-layered transcriptional and post-translational fine-tuning of metabolic pathways for overproduction of L-valine.

  2025cites this paper
• Construction and screening of L-valine high-yielding Escherichia coli using an artificial screening marker

  2025cites this paper
• Organometallic dichloro bis l-Valine Zinc(II) nonlinear optical crystal growth, nucleation investigations and characterization (DCBVZ)

  2024cites this paper
• System metabolic engineering of Escherichia coli W for the production of 2-ketoisovalerate using unconventional feedstock

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• Stratifications and foliations in phase portraits of gene network models

  2022cites this paper
• Rational metabolic engineering of Corynebacterium glutamicum to create a producer of L-valine

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• Improved production of D-pantothenic acid in Escherichia coli by integrated strain engineering and fermentation strategies.

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• An energetic profile of Corynebacterium glutamicum underpinned by measured biomass yield on ATP.

  2021cites this paper
• Transcriptome analysis of l-leucine-producing Corynebacterium glutamicum under the addition of trimethylglycine

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• Engineering of microbial cells for L-valine production: challenges and opportunities

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• L-valine production in Corynebacterium glutamicum based on systematic metabolic engineering: progress and prospects

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• Improvement of l-Valine Production by Atmospheric and Room Temperature Plasma Mutagenesis and High-Throughput Screening in Corynebacterium glutamicum

  2020cites this paper
• Corynebacterium glutamicum: Biology and Biotechnology

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  2019cites this paper
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  2019cites this paper
• Schlussbericht

  2019cites this paper
• Impact of CO2/HCO3– Availability on Anaplerotic Flux in Pyruvate Dehydrogenase Complex-Deficient Corynebacterium glutamicum Strains

  2019cites this paper
• Metabolic engineering of l-leucine production in Escherichia coli and Corynebacterium glutamicum: a review.

  2019cites this paper
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  2018influential citation
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2017cites this paper
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  2017cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
• Recent advances in amino acid production by microbial cells.

  2016cites this paper
• Investigation into the flux distribution of central carbon metabolism in Corynebacterium glutamicum using principal component analysis

  2015cites this paper
• 13C-Metabolic Flux Analysis: An Accurate Approach to Demystify Microbial Metabolism for Biochemical Production

  2015influential citation
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  2014cites this paper
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  2014cites this paper
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  2014influential citation
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  2014cites this paper
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  2014cites this paper
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  2014cites this paper
• Application of a Genetically Encoded Biosensor for Live Cell Imaging of L-Valine Production in Pyruvate Dehydrogenase Complex-Deficient Corynebacterium glutamicum Strains

  2014cites this paper
• The pyruvate dehydrogenase complex of Corynebacterium glutamicum: an attractive target for metabolic engineering.

  2014cites this paper
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  2014cites this paper
• The contest for precursors: channelling l-isoleucine synthesis in Corynebacterium glutamicum without byproduct formation

  2014cites this paper
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  2013cites this paper
• Expression of NAD(H) Kinase and Glucose-6-Phosphate Dehydrogenase Improve NADPH Supply and l-isoleucine Biosynthesis in Corynebacterium glutamicum ssp. lactofermentum

  2013cites this paper
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  2013cites this paper
• Targeted quantification of central metabolic enzymes in Corynebacterium glutamicum

  2013cites this paper
• Metabolomics in Biotechnology (Microbial Metabolomics)

  2013cites this paper
• Engineering of Corynebacterium glutamicum for High-Yield l-Valine Production under Oxygen Deprivation Conditions

  2012cites this paper
• Bio-based production of chemicals, materials and fuels -Corynebacterium glutamicum as versatile cell factory.

  2012cites this paper
• Engineering Corynebacterium glutamicum as a designer-bug for the bio-based production of chemical building blocks and biofuel

  2012cites this paper
• Tracer‐Based Analysis of Metabolic Flux Networks

  2012cites this paper
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  2012cites this paper
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  2012cites this paper
• Systems Metabolic Engineering of Corynebacterium glutamicum for Biobased Production of Chemicals, Materials and Fuels

  2012cites this paper
• Aims and Scope

  2011cites this paper