Enzymatic assays for 2,4-diamino-5-methyl-6-[(3,4,5-trimethoxyanilino)methyl]quinazoline, a promising new "nonclassical" antifolate.

No abstract is available for this paper.

• Publication year

  1981

• Venue

  Journal of Pharmacy and Science

• Publication date

  1981-07-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1002/JPS.2600700737PMID 6455513
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Inhibition of histamine-metabolizing enzymes and elevation of histamine levels in tissues by lipid-soluble anticancer folate antagonists.

  1980cited by this paper
• A Rapid Enzymatic Assay for Methotrexate in Serum

  1979cited by this paper
• 2,4-diamino-5-methyl-6-[(3,4,5-trimethoxyanilino)methyl]quinazoline (tmq), a potent non-classical folate antagonist inhibitor--I effect on dihydrofolate reductase and growth of rodent tumors in vitro and in vivo.

  1979cited by this paper
• Toward improved selectivity in cancer chemotherapy: the Richard and Hinda Rosenthal Foundation Award Lecture.

  1979cited by this paper
• Use of dihydrofolate reductase from bovine liver, rather than from L. casei, for determining methotrexate.

  1978cited by this paper
• Weekly methotrexate-calcium leucovorin rescue: effect of alkalinization on nephrotoxicity; pharmacokinetics in the CNS; and use in CNS non-Hodgkin's lymphoma.

  1977cited by this paper
• Methotrexate assay by enzymatic inhibition, with use of centrifugal analyzer.

  1977cited by this paper
• 7-Hydroxymethotrexate as a urinary metabolite in human subjects and rhesus monkeys receiving high dose methotrexate.

  1976cited by this paper
• Inhibitor binding analysis of dihydrofolate reductases from various species.

  1965cited by this paper
• Enzymatic reduction of folic acid and dihydrofolic acid to tetrahydrofolic acid.

  1957cited by this paper
• Chemistry and biology of pteridines: a Ciba Foundation Symposium, edited by G.E.W. Wolstenholme, J. and A. Churchill, Ltd., London. 1954. 425 pages, 42s

  1956cited by this paper

• Structural genomics for drug design against the pathogen Coxiella burnetii

  2015cites this paper
• Synthesis and antibacterial activity of some 5-hydroxy-5-trifluoromethyl-4,5-dihydropyrazol-1-thiocarboxamides, 3-trifluoromethylpyrazol-1-thiocarboxamides and 4-aryl-2-(5(3)-trifluoromethyl-1-pyrazolyl)thiazoles

  2011cites this paper
• Biological and biochemical properties of new anticancer folate antagonists

  2004cites this paper
• A phase I trial of trimetrexate glucuronate (NSC 352122) given every 3 weeks: clinical pharmacology and pharmacodynamics

  2004cites this paper
• Trimetrexate: a new antifol entering clinical trials

  2004cites this paper
• A phase I study of trimetrexate (NSC 352122) administered by 5-day continuous intravenous infusion

  2004cites this paper
• Novel antifolate drugs

  2003cites this paper
• Determination of plasma propofol levels using gas chromatography-mass spectrometry with selected-ion monitoring.

  1993cites this paper
• 2,4-Diaminothieno[2,3-d]pyrimidine analogues of trimetrexate and piritrexim as potential inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase.

  1993cites this paper
• Improved chromatographic method for the determination of trimetrexate in urine.

  1990cites this paper
• Phase I trial of trimetrexate glucuronate on a five-day bolus schedule: clinical pharmacology and pharmacodynamics.

  1989cites this paper
• Cellular pharmacology of chloroquinoxaline sulfonamide and a related compound in murine B16 melanoma cells.

  1988cites this paper
• Clinical pharmacology of trimetrexate

  1987cites this paper
• Determination of plasma trimetrexate levels using gas chromatography-mass spectrometry with selected-ion monitoring.

  1986cites this paper
• A Rapid and Sensitive Method for Determination of Trimetrexate from Biological Fluids

  1985cites this paper
• Biochemical pharmacology of the lipophilic antifolate, trimetrexate.

  1984cites this paper