Degradation of heme oxygenase‐1 by the immunoproteasome in astrocytes: A potential interferon‐γ‐dependent mechanism contributing to HIV neuropathogenesis

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Glia

• Publication date

  2017-05-22

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/glia.23160PMID 28543773PMCID PMC5739592
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• HIV-associated neurocognitive disorder — pathogenesis and prospects for treatment

  2016cited by this paper
• Ubiquitin-independent proteosomal degradation of myelin basic protein contributes to development of neurodegenerative autoimmunity

  2015cited by this paper
• Cerebrospinal Fluid (CSF) CD8+ T-Cells That Express Interferon-Gamma Contribute to HIV Associated Neurocognitive Disorders (HAND)

  2015influential reference
• Neuropathology of HAND With Suppressive Antiretroviral Therapy: Encephalitis and Neurodegeneration Reconsidered

  2015cited by this paper
• Signal peptide peptidase-mediated nuclear localization of heme oxygenase-1 promotes cancer cell proliferation and invasion independent of its enzymatic activity

  2015cited by this paper
• Induction of Heme Oxygenase-1 Deficiency and Associated Glutamate-Mediated Neurotoxicity Is a Highly Conserved HIV Phenotype of Chronic Macrophage Infection That Is Resistant to Antiretroviral Therapy

  2015influential reference
• Involvement of ELAV RNA-binding proteins in the post-transcriptional regulation of HO-1

  2015cited by this paper
• A Review on Hemeoxygenase-2: Focus on Cellular Protection and Oxygen Response

  2014cited by this paper
• Heme Oxygenase-1 Dysregulation in the Brain: Implications for HIV-Associated Neurocognitive Disorders

  2014cited by this paper
• Heme oxygenase-1 deficiency accompanies neuropathogenesis of HIV-associated neurocognitive disorders.

  2014influential reference
• Signal peptide peptidase-mediated nuclear localization of heme oxygenase-1 promotes cancer cell proliferation and invasion independent of its enzymatic activity

  2014cited by this paper
• Cerebrospinal fluid metabolomics reveals altered waste clearance and accelerated aging in HIV patients with neurocognitive impairment

  2014cited by this paper
• Proteasome isoforms exhibit only quantitative differences in cleavage and epitope generation

  2014cited by this paper
• Multiple Sclerosis Autoantigen Myelin Basic Protein Escapes Control by Ubiquitination during Proteasomal Degradation*

  2014cited by this paper
• Regulation of the Proteasome: Evaluating the Lung Proteasome as a New Therapeutic Target

  2014cited by this paper
• Cleavage by signal peptide peptidase is required for the degradation of selected tail-anchored proteins

  2014influential reference
• Enhanced rate of degradation of basic proteins by 26S immunoproteasomes.

  2014cited by this paper
• The balance mediated by miRNAs and the heme oxygenase 1 feedback loop contributes to biological effects

  2013cited by this paper
• The proteasome: from basic mechanisms to emerging roles.

  2013cited by this paper
• Mixed Proteasomes Function To Increase Viral Peptide Diversity and Broaden Antiviral CD8+ T Cell Responses

  2013cited by this paper
• TRC8 suppresses tumorigenesis through targeting heme oxygenase-1 for ubiquitination and degradation

  2013cited by this paper
• Regulation of the Nrf2 antioxidant pathway by microRNAs: New players in micromanaging redox homeostasis.

  2013cited by this paper
• Immunoproteasome enhances intracellular proteolysis of myelin basic protein

  2013cited by this paper
• Immunoproteasomes: structure, function, and antigen presentation.

  2012cited by this paper
• Monocyte Activation Markers in Cerebrospinal Fluid Associated With Impaired Neurocognitive Testing in Advanced HIV Infection

  2012cited by this paper
• Dimethyl Fumarate, an Immune Modulator and Inducer of the Antioxidant Response, Suppresses HIV Replication and Macrophage-Mediated Neurotoxicity: A Novel Candidate for HIV Neuroprotection

  2011influential reference
• HIV-associated neurocognitive disorders before and during the era of combination antiretroviral therapy: differences in rates, nature, and predictors

  2010cited by this paper
• Immunoproteasomes preserve protein homeostasis upon interferon-induced oxidative stress.

  2010cited by this paper
• The development of antiretroviral therapy and its impact on the HIV-1/AIDS pandemic.

  2010cited by this paper
• Mechanisms of cell protection by heme oxygenase-1.

  2010cited by this paper
• Persistent hijacking of brain proteasomes in HIV-associated dementia.

  2010influential reference
• Molecular mechanisms of proteasome assembly

  2009cited by this paper
• Cognitive dysfunction in HIV patients despite long-standing suppression of viremia

  2009cited by this paper
• Microbial Translocation Is Associated with Increased Monocyte Activation and Dementia in AIDS Patients

  2008cited by this paper
• The heme oxygenase – carbon monoxide system: regulation and role in stress response and organ failure

  2008cited by this paper
• Ubiquitin-proteasome system mediates heme oxygenase-1 degradation through endoplasmic reticulum-associated degradation pathway.

  2008cited by this paper
• Associative and predictive biomarkers of dementia in HIV-1–infected patients

  2007cited by this paper
• Heme Oxygenase-1 Protein Localizes to the Nucleus and Activates Transcription Factors Important in Oxidative Stress*

  2007cited by this paper
• How many transcription factors does it take to turn on the heme oxygenase-1 gene?

  2007cited by this paper
• Updated research nosology for HIV-associated neurocognitive disorders

  2007cited by this paper
• Regulation of heme oxygenase-1 mRNA deadenylation and turnover in NIH3T3 cells by nitrosative or alkylation stress

  2007cited by this paper
• Immune activation of the central nervous system is still present after >4 years of effective highly active antiretroviral therapy.

  2007cited by this paper
• Microbial translocation is a cause of systemic immune activation in chronic HIV infection

  2006cited by this paper
• Microbial translocation is a cause of systemic immune activation in chronic HIV infection

  2006cited by this paper
• IFN-gamma-induced immune adaptation of the proteasome system is an accelerated and transient response.

  2005influential reference
• Heme oxygenase-1: from bench to bedside.

  2005cited by this paper
• Interrater Reliability of Clinical Ratings and Neurocognitive Diagnoses in HIV

  2004cited by this paper
• Elevated expression of IFN-gamma in the HIV-1 infected brain.

  2004cited by this paper
• Immunoproteasomes Down-Regulate Presentation of a Subdominant T Cell Epitope from Lymphocytic Choriomeningitis Virus1

  2004cited by this paper
• Protein kinase Akt/PKB phosphorylates heme oxygenase‐1 in vitro and in vivo

  2004cited by this paper
• Different Faces of the Heme-Heme Oxygenase System in Inflammation

  2003cited by this paper
• Heme oxygenase-1: the "emerging molecule" has arrived.

  2002cited by this paper
• Gene Transfection of H25A Mutant Heme Oxygenase-1 Protects Cells against Hydroperoxide-induced Cytotoxicity*

  2002cited by this paper
• Heme oxygenase/carbon monoxide signaling pathways: Regulation and functional significance

  2002cited by this paper
• Isolated human astrocytes are not susceptible to infection by M‐ and T‐tropic HIV‐1 strains despite functional expression of the chemokine receptors CCR5 and CXCR4

  2001cited by this paper
• Regulation of proteasome complexes by gamma-interferon and phosphorylation.

  2001cited by this paper
• Immunoproteasomes Largely Replace Constitutive Proteasomes During an Antiviral and Antibacterial Immune Response in the Liver1

  2001cited by this paper
• The National NeuroAIDS Tissue Consortium:a new paradigm in brain banking with an emphasis on infectious disease

  2001cited by this paper
• Interferon-γ inducible exchanges of 20S proteasome active site subunits: Why?

  2001cited by this paper
• Regulation of proteasome complexes by γ-interferon and phosphorylation

  2001cited by this paper
• Interferon-gamma inducible exchanges of 20S proteasome active site subunits: why?

  2001cited by this paper
• Heme oxygenase activity. Current methods and applications.

  2000cited by this paper
• Different proteasome subtypes in a single tissue exhibit different enzymatic properties.

  2000cited by this paper
• Biochemical analysis of proteasomes from mouse microglia: Induction of immunoproteasomes by interferon‐γ and lipopolysaccharide

  2000cited by this paper
• Clonal Expansions of Cd8+ T Cells Dominate the T Cell Infiltrate in Active Multiple Sclerosis Lesions as Shown by Micromanipulation and Single Cell Polymerase Chain Reaction

  2000cited by this paper
• Transcription Factor Nrf2 Coordinately Regulates a Group of Oxidative Stress-inducible Genes in Macrophages*

  2000influential reference
• Intermediates in the formation of mouse 20S proteasomes: implications for the assembly of precursor beta subunits.

  1997cited by this paper
• Intermediates in the formation of mouse 20S proteasomes: implications for the assembly of precursor β subunits

  1997cited by this paper
• Cellular localization of tumor necrosis factor mRNA in neurological tissue from HIV-infected patients by combined reverse transcriptase/polymerase chain reaction in situ hybridization and immunohistochemistry.

  1997cited by this paper
• Perspectives Series : Cytokines and the Brain Cytokines in the Brain during Viral Infection : Clues to HIV-associated Dementia

  1997cited by this paper
• Identification of MECL-1 (LMP-10) as the third IFN-gamma-inducible proteasome subunit.

  1996cited by this paper
• cDNA cloning and interferon gamma down-regulation of proteasomal subunits X and Y.

  1994cited by this paper
• Interferon-gamma induces different subunit organizations and functional diversity of proteasomes.

  1994cited by this paper
• Displacement of housekeeping proteasome subunits by MHC‐encoded LMPs: a newly discovered mechanism for modulating the multicatalytic proteinase complex.

  1994cited by this paper
• Neopterin and interferon‐gamma in serum and cerebrospinal fluid of patients with HIV‐associated neurologic disease

  1991cited by this paper
• HIV‐Associated Disease of the Nervous System: Review of Nomenclature and Proposal for Neuropathology‐Based Terminology

  1991cited by this paper
• Interferon-gamma concentrations are increased in sera from individuals infected with human immunodeficiency virus type 1.

  1989influential reference
• Neopterin concentrations in cerebrospinal fluid and serum of individuals infected with HIV-1.

  1989influential reference
• Half-life of proteasomes (multiprotease complexes) in rat liver.

  1989cited by this paper

• Implications and prospects of immunological and neuroimaging research in HIV-associated neurocognitive disorders.

  2026cites this paper
• A critical role for Macrophage-derived Cysteinyl-Leukotrienes in HIV-1 induced neuronal injury.

  2024cites this paper
• Rutin prevents EqHV-8 induced infection and oxidative stress via Nrf2/HO-1 signaling pathway

  2024cites this paper
• Hyperoside inhibits EHV-8 infection via alleviating oxidative stress and IFN production through activating JNK/Keap1/Nrf2/HO-1 signaling pathways

  2024cites this paper
• Heme oxygenase 1 in erythropoiesis: an important regulator beyond catalyzing heme catabolism

  2023cites this paper
• A Journey into the Clinical Relevance of Heme Oxygenase 1 for Human Inflammatory Disease and Viral Clearance: Why Does It Matter on the COVID-19 Scene?

  2022cites this paper
• Neuropathogenesis of HIV-1: insights from across the spectrum of acute through long-term treated infection

  2022cites this paper
• Developments in Neuroprotection for HIV-Associated Neurocognitive Disorders (HAND)

  2022cites this paper
• Hemeoxygenase and its metabolites in regulation of vascular endothelial health

  2021cites this paper
• A Nature-Inspired Nrf2 Activator Protects Retinal Explants from Oxidative Stress and Neurodegeneration

  2021cites this paper
• Neuroinflammation associates with antioxidant heme oxygenase-1 response throughout the brain in persons living with HIV

  2020influential citation
• Design and synthesis of HLA-A*02-restricted Hantaan virus multiple-antigenic peptide for CD8+ T cells

  2020cites this paper
• Heme oxygenase-1 promoter (GT)n polymorphism associates with HIV neurocognitive impairment

  2020influential citation
• Lipocalin-2 Mediates HIV-1 Induced Neuronal Injury and Behavioral Deficits by Overriding CCR5-dependent Protection.

  2020cites this paper
• Immune response and blood–brain barrier dysfunction during viral neuroinvasion

  2020cites this paper
• 7,8-Dihydroxyflavone improves neuropathological changes in the brain of Tg26 mice, a model for HIV-associated neurocognitive disorder

  2020cites this paper
• Antineuroinflammatory drugs in HIV-associated neurocognitive disorders as potential therapy

  2019cites this paper
• PA28α/β Promote Breast Cancer Cell Invasion and Metastasis via Down-Regulation of CDK15

  2019cites this paper
• Friends Turn Foe—Astrocytes Contribute to Neuronal Damage in NeuroAIDS

  2019cites this paper
• DMO-CAP inhibits influenza virus replication by activating heme oxygenase-1-mediated IFN response

  2019cites this paper
• Heme oxygenase-1 deficiency promotes severity of sepsis in a non-surgical preterm mouse model

  2018cites this paper
• A Dual Role of Heme Oxygenase-1 in Cancer Cells

  2018cites this paper
• Heme oxygenase-1 promoter region (GT)n polymorphism associates with increased neuroimmune activation and risk for encephalitis in HIV infection

  2018cites this paper