In vitro response of human dermal fibroblasts to X-irradiation: relationship between radiation-induced clonogenic cell death, chromosome aberrations and markers of proliferative senescence or differentiation

No abstract is available for this paper.

• Publication year

  2001

• Venue

  International Journal of Radiation Biology

• Publication date

  2001-01-01

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1080/09553000110086372PMID 11747541
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Molecular and cellular basis of radiation fibrosis.

  2009cited by this paper
• Normal tissue radiobiology: from the laboratory to the clinic.

  2001cited by this paper
• TGF-beta1-mediated alterations of rat lung fibroblast differentiation resulting in the radiation-induced fibrotic phenotype.

  2000influential reference
• Spontaneous and radiation-induced differentiationof fibroblasts.

  2000influential reference
• Relationship between DNA double-strand breaks, cell killing, and fibrosis studied in confluent skin fibroblasts derived from breast cancer patients.

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