Structure and Functional Analysis of ClbQ, an Unusual Intermediate-Releasing Thioesterase from the Colibactin Biosynthetic Pathway.

No abstract is available for this paper.

• Publication year

  2017

• Venue

  ACS Chemical Biology

• Publication date

  2017-09-08

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1021/acschembio.7b00479PMID 28846367PMCID PMC5830302
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The microbiome and cancer

  2018cited by this paper
• Domain-Targeted Metabolomics Delineates the Heterocycle Assembly Steps of Colibactin Biosynthesis.

  2017cited by this paper
• Colibactin assembly line enzymes use S-adenosylmethionine to build a cyclopropane ring

  2017cited by this paper
• Polyketide synthase and non-ribosomal peptide synthetase thioesterase selectivity: logic gate or a victim of fate?

  2016cited by this paper
• A Mechanistic Model for Colibactin-Induced Genotoxicity.

  2016cited by this paper
• Convergent and Modular Synthesis of Candidate Precolibactins. Structural Revision of Precolibactin A.

  2016cited by this paper
• Natural Products as Sources of New Drugs from 1981 to 2014.

  2016cited by this paper
• Characterization of Polyketide Synthase Machinery from the pks Island Facilitates Isolation of a Candidate Precolibactin.

  2016cited by this paper
• Divergent biosynthesis yields a cytotoxic aminomalonate-containing precolibactin

  2016cited by this paper
• Role and mechanisms of action of Escherichia coli Nissle 1917 in the maintenance of remission in ulcerative colitis patients: An update.

  2016cited by this paper
• Cancer and the microbiota

  2015cited by this paper
• JPred4: a protein secondary structure prediction server

  2015cited by this paper
• Colibactin biosynthesis and biological activity depend on the rare aminomalonyl polyketide precursor.

  2015cited by this paper
• Intracellular colon cancer-associated Escherichia coli promote protumoral activities of human macrophages by inducing sustained COX-2 expression

  2015cited by this paper
• Critical Intermediates Reveal New Biosynthetic Events in the Enigmatic Colibactin Pathway

  2015cited by this paper
• Crystal Structure and Substrate Specificity of Human Thioesterase 2

  2015cited by this paper
• Colibactin: understanding an elusive gut bacterial genotoxin.

  2015cited by this paper
• Comparative Metabolomics and Structural Characterizations Illuminate Colibactin Pathway-Dependent Small Molecules

  2014cited by this paper
• Roles of type II thioesterases and their application for secondary metabolite yield improvement

  2014cited by this paper
• Bacterial genotoxin colibactin promotes colon tumour growth by inducing a senescence-associated secretory phenotype

  2014cited by this paper
• The interplay between the gut microbiota and the immune system

  2014cited by this paper
• In Vivo Evidence for a Prodrug Activation Mechanism during Colibactin Maturation

  2013cited by this paper
• A prodrug resistance mechanism is involved in colibactin biosynthesis and cytotoxicity.

  2013cited by this paper
• The microbiome and cancer

  2013cited by this paper
• Interactions Between the Microbiota and the Immune System

  2012cited by this paper
• Genotoxicity of Escherichia coli Nissle 1917 strain cannot be dissociated from its probiotic activity

  2012cited by this paper
• Analysis of structure-function relationships in the colibactin-maturating enzyme ClbP.

  2012cited by this paper
• Intestinal Inflammation Targets Cancer-Inducing Activity of the Microbiota

  2012cited by this paper
• Towards automated crystallographic structure refinement with phenix.refine

  2012cited by this paper
• Structure and Function of the RedJ Protein, a Thioesterase from the Prodiginine Biosynthetic Pathway in Streptomyces coelicolor*

  2011cited by this paper
• ClbP Is a Prototype of a Peptidase Subgroup Involved in Biosynthesis of Nonribosomal Peptides*

  2011cited by this paper
• Policing starter unit selection of the enterocin type II polyketide synthase by the type II thioesterase EncL.

  2011cited by this paper
• Structural basis for phosphopantetheinyl carrier domain interactions in the terminal module of nonribosomal peptide synthetases.

  2011cited by this paper
• Dali server: conservation mapping in 3D

  2010cited by this paper
• Escherichia coli induces DNA damage in vivo and triggers genomic instability in mammalian cells

  2010cited by this paper
• Biochemical and Genetic Insights into Asukamycin Biosynthesis*

  2010cited by this paper
• The gut microbiota shapes intestinal immune responses during health and disease

  2009cited by this paper
• Structure and Functional Analysis of RifR, the Type II Thioesterase from the Rifamycin Biosynthetic Pathway*

  2009cited by this paper
• Genetic Structure and Distribution of the Colibactin Genomic Island among Members of the Family Enterobacteriaceae

  2009cited by this paper
• Nonribosomal peptide synthetases involved in the production of medically relevant natural products.

  2008cited by this paper
• Structure elucidation and biosynthesis of fuscachelins, peptide siderophores from the moderate thermophile Thermobifida fusca

  2008cited by this paper
• Structural basis for the selectivity of the external thioesterase of the surfactin synthetase

  2008cited by this paper
• Selective Removal of Aberrant Extender Units by a Type II Thioesterase for Efficient FR-008/Candicidin Biosynthesis in Streptomyces sp. Strain FR-008

  2008cited by this paper
• Phaser crystallographic software

  2007cited by this paper
• Expression analysis of the colibactin gene cluster coding for a novel polyketide in Escherichia coli.

  2007cited by this paper
• Escherichia coli Induces DNA Double-Strand Breaks in Eukaryotic Cells

  2006cited by this paper
• Identification of NanE as the thioesterase for polyether chain release in nanchangmycin biosynthesis.

  2006cited by this paper
• Evidence that a Novel Thioesterase is Responsible for Polyketide Chain Release during Biosynthesis of the Polyether Ionophore Monensin

  2006cited by this paper
• Site-specific protein labeling by Sfp phosphopantetheinyl transferase

  2006cited by this paper
• Type II Thioesterase Restores Activity of a NRPS Module Stalled with an Aminoacyl‐S‐enzyme that Cannot Be Elongated

  2004cited by this paper
• Coot: model-building tools for molecular graphics.

  2004cited by this paper
• Structural basis for the cyclization of the lipopeptide antibiotic surfactin by the thioesterase domain SrfTE.

  2002cited by this paper
• Regeneration of misprimed nonribosomal peptide synthetases by type II thioesterases

  2002cited by this paper
• Role of type II thioesterases: evidence for removal of short acyl chains produced by aberrant decarboxylation of chain extender units.

  2001cited by this paper
• Characterization of Sfp, a Bacillus subtilis phosphopantetheinyl transferase for peptidyl carrier protein domains in peptide synthetases.

  1998cited by this paper
• Genetic evidence for a role of thioesterase domains, integrated in or associated with peptide synthetases, in non-ribosomal peptide biosynthesis in Bacillus subtilis

  1998cited by this paper
• Modular Peptide Synthetases Involved in Nonribosomal Peptide Synthesis.

  1997cited by this paper
• The α/β hydrolase fold

  1992cited by this paper
• The alpha/beta hydrolase fold.

  1992cited by this paper

• Characterization of a Novel Fatty Acid-Modifying Pathway in the Biosynthesis of Tambjamine BE-18591 in Streptomyces.

  2025cites this paper
• Structural study on human microbiome-derived polyketide synthases that assemble genotoxic colibactin.

  2025cites this paper
• Prevalence of polyketide synthase (PKS) genotoxin among Escherichia coli isolated from clinical sources

  2025cites this paper
• Molecular Basis for Short-Chain Thioester Hydrolysis by Acyl Hydrolases in trans-Acyltransferase Polyketide Synthases

  2024cites this paper
• Analysis of the partial sequencing of clbA, clbB and clbQ in Escherichia coli isolates that produce colibactin and multilocus sequence typing

  2024cites this paper
• Current understandings of colibactin regulation

  2024cites this paper
• The Rapid Synthesis of Colibactin Warhead Model Compounds Using New Metal-Free Photocatalytic Cyclopropanation Reactions Facilitates the Investigation of Biological Mechanisms.

  2023cites this paper
• Targeted depletion of pks+ bacteria from a fecal microbiota using specific antibodies

  2023cites this paper
• Biosynthesis and bioactivities of microbial genotoxin colibactins.

  2022cites this paper
• Multiple Functions of the Type II Thioesterase Associated with the Phoslactomycin Polyketide Synthase

  2022cites this paper
• Advancing the Biosynthetic and Chemical Understanding of the Carcinogenic Risk Factor Colibactin and Its Producers.

  2022cites this paper
• Protein-protein interface analysis of the non-ribosomal peptide synthetase peptidyl carrier protein and enzymatic domains

  2022cites this paper
• Thioesterase enzyme families: Functions, structures, and mechanisms

  2021cites this paper
• Chain release mechanisms in polyketide and non-ribosomal peptide biosynthesis.

  2021cites this paper
• “Effect of Subinhibitory Concentrations of Some Antibiotics and Low Doses of Gamma Radiation on the Cytotoxicity and Expression of Colibactin by an Uropathogenic Escherichia coli isolate”

  2021cites this paper
• ClbR Is the Key Transcriptional Activator of Colibactin Gene Expression in Escherichia coli

  2020cites this paper
• Hybrid Peptide–Polyketide Natural Product Biosynthesis

  2020cites this paper
• Structure and function of BorB, the type II thioesterase from the borrelidin biosynthetic gene cluster.

  2020cites this paper
• The accumulation of colibactin intermediates does not affect the growth and morphology of pks+ Escherichia coli

  2020cites this paper
• Structure, function, and regulation of thioesterases.

  2020cites this paper
• Structure and bioactivity of colibactin.

  2020cites this paper
• Erratum for Wallenstein et al., “ClbR Is the Key Transcriptional Activator of Colibactin Gene Expression in Escherichia coli”

  2020cites this paper
• Biosynthesis of depsipeptides, or Depsi: The peptides with varied generations

  2020cites this paper
• Pre-proof Structure , function , and regulation of thioesterases

  2020cites this paper
• Synthesis and reactivity of precolibactin 886

  2019cites this paper
• Chemistry and Enzymology Encoded by the Human Microbiome

  2019cites this paper
• Structure elucidation of colibactin

  2019cites this paper
• Structure elucidation of colibactin and its DNA cross-links

  2019cites this paper
• Macrocyclic colibactin induces DNA double-strand breaks via copper-mediated oxidative cleavage

  2019cites this paper
• The Polyamine Spermidine Modulates the Production of the Bacterial Genotoxin Colibactin

  2019cites this paper
• Structural Biology of Nonribosomal Peptide Synthetases

  2019cites this paper
• Hot off the press.

  2018cites this paper
• Étude des métabolites liés à l’îlot pks chez les souches urinaires de Escherichia coli

  2018cites this paper
• The Colibactin Genotoxin Generates DNA Interstrand Cross-Links in Infected Cells

  2018cites this paper
• YbtT - Type II thioesterase from Yersiniabactin NRPS/PKS biosynthetic pathway

  2018cites this paper
• Model colibactins exhibit human cell genotoxicity in the absence of host bacteria

  2018cites this paper
• YbtT is a low-specificity type II thioesterase that maintains production of the metallophore yersiniabactin in pathogenic enterobacteria

  2018cites this paper
• Colibactin: More Than a New Bacterial Toxin

  2018cites this paper