Hepatocytes isolated from preneoplastic rat livers are resistant to ethacrynic acid cytotoxicity

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Archives of Toxicology

• Publication date

  2007-03-06

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s00204-007-0183-8PMID 17340122
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Interferon alpha-induced apoptosis on rat preneoplastic liver is mediated by hepatocytic transforming growth factor beta(1).

  2004cited by this paper
• Interferon α‐induced apoptosis on rat preneoplastic liver is mediated by hepatocytic transforming growth factor β1

  2004cited by this paper
• Ethacrynic-acid-induced glutathione depletion and oxidative stress in normal and Mrp2-deficient rat liver.

  2004cited by this paper
• Hepatocellular carcinoma: present status and future prospects.

  2003cited by this paper
• Toxicity of ethacrynic acid in isolated rat hepatocytes.

  2002influential reference
• The in vivo apoptotic effect of interferon alfa‐2b on rat preneoplastic liver involves Bax protein

  2002cited by this paper
• Glutathione S‐transferases

  2002cited by this paper
• Expression of the multidrug resistance proteins MRP2 and MRP3 in human hepatocellular carcinoma

  2001cited by this paper
• Glutathione and glutathione-dependent enzymes represent a co-ordinately regulated defence against oxidative stress.

  1999cited by this paper
• Epidemiology of Primary Liver Cancer

  1999cited by this paper
• Uptake and glutathione conjugation of ethacrynic acid and efflux of the glutathione adduct by periportal and perivenous rat hepatocytes.

  1999cited by this paper
• Drug export activity of the human canalicular multispecific organic anion transporter in polarized kidney MDCK cells expressing cMOAT (MRP2) cDNA.

  1998cited by this paper
• Combined expression of multidrug resistance protein (MRP) and glutathione S-transferase P1-1 (GSTP1-1) in MCF7 cells and high level resistance to the cytotoxicities of ethacrynic acid but not oxazaphosphorines or cisplatin.

  1998cited by this paper
• Inhibition of glutathione S-transferase activity in human melanoma cells by α,β-unsaturated carbonyl derivatives. Effects of acrolein, cinnamaldehyde, citral, crotonaldehyde, curcumin, ethacrynic acid, and trans-2-hexenal

  1996cited by this paper
• Isolation and characterization of rat cholangiocyte vesicles enriched in apical or basolateral plasma membrane domains.

  1995cited by this paper
• Hepatic neoformations.

  1994cited by this paper
• Increased levels of glutathione S-transferase pi transcript as a mechanism of resistance to ethacrynic acid.

  1992cited by this paper
• Hepsulfam sensitivity in human breast cancer cell lines: the role of glutathione and glutathione S-transferase in resistance.

  1992cited by this paper
• The role of glutathione-dependent enzymes in drug resistance.

  1991cited by this paper
• Glutathione S-transferases: role in alkylating agent resistance and possible target for modulation chemotherapy--a review.

  1990cited by this paper
• Inhibition of rat and human glutathione S-transferase isoenzymes by ethacrynic acid and its glutathione conjugate.

  1990cited by this paper
• The role of glutathione and glutathione transferases in chemical carcinogenesis.

  1990cited by this paper
• Glutathione S-transferases and drug resistance.

  1990cited by this paper
• The Significance of Chemically-Induced Hepatocellular Altered Foci in Rat Liver and Application to Carcinogen Detection∗

  1989cited by this paper
• Glutathione transferases in rat hepatoma cells. Effects of ascites cells on the isoenzyme pattern in liver and induction of glutathione transferases in the tumour cells.

  1989cited by this paper
• Critical Parameters in the Quantitation of the Stages of Initiation, Promotion, and Progression in One Model of Hepatocarcinogenesis in the Rat∗

  1989cited by this paper
• Toxicity of uricosuric diuretics in rat hepatocyte culture.

  1989cited by this paper
• Glutathione transferases as markers of preneoplasia and neoplasia.

  1989cited by this paper
• Glutathione transferases--structure and catalytic activity.

  1988influential reference
• Overexpression of a novel anionic glutathione transferase in multidrug-resistant human breast cancer cells.

  1986cited by this paper
• Glutathione transferases in primary rat hepatomas: the isolation of a form with GSH peroxidase activity

  1985influential reference
• Identification of three classes of cytosolic glutathione transferase common to several mammalian species: correlation between structural data and enzymatic properties.

  1985cited by this paper
• Purification, induction, and distribution of placental glutathione transferase: a new marker enzyme for preneoplastic cells in the rat chemical hepatocarcinogenesis.

  1985cited by this paper
• Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction.

  1979cited by this paper
• Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction

  1979cited by this paper
• Glutathione transferases. Catalysis of nucleophilic reactions of glutathione.

  1978cited by this paper
• Glutathione S-transferases. The first enzymatic step in mercapturic acid formation.

  1974cited by this paper
• Preparation of rat liver cells. II. Effects of ions and chelators on tissue dispersion.

  1973cited by this paper
• Preparation of rat liver cells. 3. Enzymatic requirements for tissue dispersion.

  1973cited by this paper
• Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues.

  1969cited by this paper
• Protein measurement with the Folin phenol reagent.

  1951cited by this paper

• The chemoprotective effects of IFN-α-2b on rat hepatocarcinogenesis are blocked by vitamin E supplementation.

  2021cites this paper
• Reactive Oxygen Species Act as Signaling Molecules in Liver Carcinogenesis

  2012cites this paper
• Quercetin Inhibits Diethylnitrosamine-Induced Hepatic Preneoplastic Lesions in Rats

  2011cites this paper
• Regulation of hepatic ABCC transporters by xenobiotics and in disease states

  2010cites this paper
• Attenuation of the Wnt/β-catenin/TCF pathway by in vivo interferon-α2b (IFN-α2b) treatment in preneoplastic rat livers

  2010cites this paper
• The dilemma of cultivated hepatocytes

  2009cites this paper
• Cross-talk between IFN-α and TGF-β1 signaling pathways in preneoplastic rat liver

  2009cites this paper
• Predicting drug metabolism-dependent toxicity

  2009cites this paper
• A new series of review articles on drug metabolizing enzymes: nomenclature of isoenzyme families, genetic organization, polymorphisms, substrate specificities, clinical relevance and role in carcinogenesis

  2008cites this paper