Hypoxia-stimulated cardiac fibroblast production of IL-6 promotes myocardial fibrosis via the TGF-β1 signaling pathway

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Laboratory Investigation

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/labinvest.2016.84PMID 27562310
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Hypoxia-stimulated cardiac fibroblast production of IL-6 promotes myocardial fibrosis via the TGF-β1 signaling pathway

  2016cited by this paper

• IL-6 trans-signaling activates the TGF-β pathway via soluble factors in difficult-to-treat rheumatoid arthritis joint fluid.

  2026cites this paper
• TET3 is a regulator and can be targeted for the intervention of myocardial fibrosis

  2025cites this paper
• Cellular crosstalk in fibrosis: Insights into macrophage and fibroblast dynamics

  2025cites this paper
• The endogenous glutamatergic transmitter system promotes collagen synthesis in cardiac fibroblasts under hypoxia

  2025cites this paper
• Risk factors and management of lung cancer in idiopathic pulmonary fibrosis: A comprehensive review

  2025cites this paper
• Cell autonomous TLR4 signaling modulates TGF-β induced activation of human cardiac fibroblasts

  2025cites this paper
• Oxidative stress and ferroptosis in diabetic cardiomyopathy: mechanistic interplay and therapeutic implications

  2025cites this paper
• IL‐6 in the spotlight: From cardiovascular pathophysiology to therapy

  2025cites this paper
• Retinal ALKBH5 inhibition induces myopia protection through selective regulation of ERK1/2 signaling

  2025cites this paper
• Interleukin 6 at menstruation promotes the proliferation and self-renewal of endometrial mesenchymal stromal/stem cells through the WNT/β-catenin signaling pathway

  2024cites this paper
• Modeling the contribution of cardiac fibroblasts in dilated cardiomyopathy using induced pluripotent stem cells (iPSCs).

  2024cites this paper
• The Abl1 tyrosine kinase is a key player in doxorubicin-induced cardiomyopathy and its p53/p73 cell death mediated signaling differs in atrial and ventricular cardiomyocytes

  2024cites this paper
• Synbiotic supplementation ameliorates anxiety and myocardial ischaemia–reperfusion injury in hyperglycaemic rats by modulating gut microbiota

  2024cites this paper
• Hypoxic–Normoxic Crosstalk Activates Pro‐Inflammatory Signaling in Human Cardiac Fibroblasts and Myocytes in a Post‐Infarct Myocardium on a Chip

  2024cites this paper
• Acute Pancreatitis and Myocardial Infarction: A Narrative Review

  2023cites this paper
• Protective effects of epigallocatechin-3-gallate counteracting the chronic hypobaric hypoxia-induced myocardial injury in plain-grown rats at high altitude

  2023cites this paper
• Persistent hypoxia promotes myofibroblast differentiation via GPR‐81 and differential regulation of LDH isoenzymes in normal and idiopathic pulmonary fibrosis fibroblasts

  2023cites this paper
• Tebuconazole Induces ER-Stress-Mediated Cell Death in Bovine Mammary Epithelial Cell Lines

  2023cites this paper
• Hypothalamic Oxytocin Neuron Activation Attenuates Intermittent Hypoxia-Induced Hypertension and Cardiac Dysfunction in an Animal Model of Sleep Apnea

  2023cites this paper
• L-carnitine attenuated hyperuricemia-associated left ventricular remodeling through ameliorating cardiomyocytic lipid deposition

  2023cites this paper
• Signaling Pathways and Potential Therapeutic Strategies in Cardiac Fibrosis

  2023cites this paper
• IL-6 inhibitors effectively reverse post-infarction cardiac injury and ischemic myocardial remodeling via the TGF-β1/Smad3 signaling pathway

  2022cites this paper
• AMPK/Sirt1-mediated inflammation is positively correlated with myocardial fibrosis during ageing

  2022cites this paper
• Fibrotic Signaling in Cardiac Fibroblasts and Vascular Smooth Muscle Cells: The Dual Roles of Fibrosis in HFpEF and CAD

  2022cites this paper
• Quercetin inhibits the amphiregulin/EGFR signaling‐mediated renal tubular epithelial‐mesenchymal transition and renal fibrosis in obstructive nephropathy

  2022cites this paper
• Effect of Interleukin 6 on Scleral Fibroblast Proliferation, Differentiation, and Apoptosis Involved in Myopic Scleral Remodeling

  2022cites this paper
• A narrative review of research advances in hypoxic pulmonary hypertension

  2022cites this paper
• Fibrosis in frozen shoulder: Activation of IL-6 through PI3K-Akt signaling pathway in synovial fibroblast.

  2022cites this paper
• Comprehensive Mechanism, Novel Markers and Multidisciplinary Treatment of Severe Acute Pancreatitis-Associated Cardiac Injury – A Narrative Review

  2021influential citation
• Hypoxia-induced amniotic fluid stem cell secretome augments cardiomyocyte proliferation and enhances cardioprotective effects under hypoxic-ischemic conditions

  2021cites this paper
• Donor Preconditioning with Inhaled Sevoflurane Mitigates the Effects of Ischemia-Reperfusion Injury in a Swine Model of Lung Transplantation

  2021cites this paper
• In vitro and In silico Models to Study SARS-CoV-2 Infection: Integrating Experimental and Computational Tools to Mimic “COVID-19 Cardiomyocyte”

  2021influential citation
• A cannabinoid receptor agonist shows anti-inflammatory and survival properties in human SARS-CoV-2-infected iPSC-derived cardiomyocytes

  2021cites this paper
• Selective Interleukin-6 Trans-Signaling Blockade Is More Effective Than Panantagonism in Reperfused Myocardial Infarction

  2021cites this paper
• Scoping review and interpretation of myofascial pain/fibromyalgia syndrome: An attempt to assemble a medical puzzle

  2021cites this paper
• Engineering the Cellular Microenvironment of Post-infarct Myocardium on a Chip

  2021cites this paper
• Low‐intensity pulsed ultrasound prevents prolonged hypoxia‐induced cardiac fibrosis through HIF‐1α/DNMT3a pathway via a TRAAK‐dependent manner

  2021cites this paper
• WIN 55,212-2 shows anti-inflammatory and survival properties in human iPSC-derived cardiomyocytes infected with SARS-CoV-2

  2021cites this paper
• Fibroblast‐mediated intercellular crosstalk in the healthy and diseased heart

  2021cites this paper
• Matrix metalloproteinase 3 regulates angiotensin II-induced myocardial fibrosis cell viability, migration and apoptosis

  2020cites this paper
• TGF-β pathway activation by idiopathic pulmonary fibrosis (IPF) fibroblast derived soluble factors is mediated by IL-6 trans-signaling

  2020cites this paper
• Human Atrial Fibroblast Adaptation to Heterogeneities in Substrate Stiffness

  2020cites this paper
• β2-Adrenergic Receptors Increase Cardiac Fibroblast Proliferation Through the Gαs/ERK1/2-Dependent Secretion of Interleukin-6

  2020cites this paper
• Let‐7 mediated airway remodelling in chronic obstructive pulmonary disease via the regulation of IL‐6

  2020cites this paper
• Tocilizumab improves oxidative stress and endothelial glycocalyx: A mechanism that may explain the effects of biological treatment on COVID-19

  2020cites this paper
• Tyrosyl phosphorylation of PZR promotes hypertrophic cardiomyopathy in PTPN11-associated Noonan syndrome with multiple lentigines.

  2020cites this paper
• Pathogenic Roles of Autoantibodies and Aberrant Epigenetic Regulation of Immune and Connective Tissue Cells in the Tissue Fibrosis of Patients with Systemic Sclerosis

  2020cites this paper
• The effector cells and cellular mediators of immune system involved in cardiac inflammation and fibrosis after myocardial infarction

  2020cites this paper
• Interleukin-6 antagonism in a rat model of acute myocardial infarction

  2019cites this paper
• Atorvastatin Prevents Myocardial Fibrosis in Spontaneous Hypertension via Interleukin-6 (IL-6)/Signal Transducer and Activator of Transcription 3 (STAT3)/Endothelin-1 (ET-1) Pathway

  2019cites this paper
• Etude du remodelage du ventricule droit dans l’hypertension pulmonaire : du phénotypage approfondi à l'étude de la protéomique

  2019cites this paper
• LncRNA ROR facilitates myocardial fibrosis in rats with viral myocarditis through regulating C-Myc expression.

  2019cites this paper
• Prostaglandin E1 protects cardiomyocytes against hypoxia-reperfusion induced injury via the miR-21-5p/FASLG axis

  2019cites this paper
• Doxorubicin induces trans-differentiation and MMP1 expression in cardiac fibroblasts via cell death-independent pathways

  2019cites this paper
• β-Arrestin 2 mediates arginine vasopressin-induced IL-6 induction via the ERK1/2-NF-κB signal pathway in murine hearts

  2019cites this paper
• Lysophosphatidylcholine-induced mitochondrial fission contributes to collagen production in human cardiac fibroblasts[S]

  2019cites this paper
• Acute Hyperthermia Inhibits TGF-β1-induced Cardiac Fibroblast Activation via Suppression of Akt Signaling

  2018cites this paper
• Lysophosphatidylcholine induces cyclooxygenase-2-dependent IL-6 expression in human cardiac fibroblasts

  2018cites this paper
• Long noncoding RNA TUG1 promotes cardiac fibroblast transformation to myofibroblasts via miR‑29c in chronic hypoxia.

  2018cites this paper
• Therapeutic interleukin-6 blockade reverses transforming growth factor-beta pathway activation in dermal fibroblasts: insights from the faSScinate clinical trial in systemic sclerosis

  2018cites this paper
• Transient receptor potential vanilloid-3 (TRPV3) activation plays a central role in cardiac fibrosis induced by pressure overload in rats via TGF-β1 pathway

  2018cites this paper
• Bone Marrow-Derived Mesenchymal Stem Cells Expressing Thioredoxin 1 Attenuate Bleomycin-Induced Skin Fibrosis and Oxidative Stress in Scleroderma.

  2017cites this paper
• GRK2 Mediates Arginine Vasopressin-Induced Interleukin-6 Production via Nuclear Factor-κB Signaling Neonatal Rat Cardiac Fibroblast

  2017cites this paper
• GRK2 mediates arginine vasopressin-induced IL-6 production via NF-k B signaling in neonatal rat cardiac fibroblasts

  2016cites this paper
• Mechanobiology of Cardiac Disease and Fibrosis: a Novel Role for Cadherin-11

  2016cites this paper