Human Scythe contains a functional nuclear localization sequence and remains in the nucleus during staurosporine-induced apoptosis.

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Biochemical and Biophysical Research Communications - BBRC

• Publication date

  2001-10-12

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1006/BBRC.2001.5701PMID 11587531
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Cloning and Functional Analysis of BAG-l: A Novel Bcl-2-Binding Protein with Anti-Cell Death Activity

  2004cited by this paper
• Structure-Function Analysis of Bag1 Proteins

  2001cited by this paper
• Bag1–Hsp70 mediates a physiological stress signalling pathway that regulates Raf-1/ERK and cell growth

  2001cited by this paper
• Reversible inhibition of Hsp70 chaperone function by Scythe and Reaper

  2001cited by this paper
• Rapid caspase‐3 activation during apoptosis revealed using fluorescence‐resonance energy transfer

  2000cited by this paper
• A family of ubiquitin‐like proteins binds the ATPase domain of Hsp70‐like Stch

  2000cited by this paper
• The Ubiquitin-related BAG-1 Provides a Link between the Molecular Chaperones Hsc70/Hsp70 and the Proteasome*

  2000cited by this paper
• Induction of apoptosis by Drosophila reaper, hid and grim through inhibition of IAP function

  2000cited by this paper
• Reaper‐induced dissociation of a Scythe‐sequestered cytochrome c‐releasing activity

  1999cited by this paper
• Cloning and Characterization of Rat BAT3 cDNA

  1999cited by this paper
• Protein translocation in apoptosis.

  1999cited by this paper
• The neuroprotective potential of heat shock protein 70 (HSP70).

  1999cited by this paper
• Death by design: mechanism and control of apoptosis.

  1999cited by this paper
• An Evolutionarily Conserved Family of Hsp70/Hsc70 Molecular Chaperone Regulators*

  1999cited by this paper
• Caspases: enemies within.

  1998cited by this paper
• Expression and location of Hsp70/Hsc-binding anti-apoptotic protein BAG-1 and its variants in normal tissues and tumor cell lines.

  1998cited by this paper
• Apoptosis Induced by Drosophila Reaper and Grim in a Human System

  1998cited by this paper
• Scythe: a novel reaper‐binding apoptotic regulator

  1998cited by this paper
• Importins and exportins: how to get in and out of the nucleus.

  1998cited by this paper
• Nucleocytoplasmic transport: signals, mechanisms and regulation

  1997cited by this paper
• Bcl-2 interacting protein, BAG-1, binds to and activates the kinase Raf-1.

  1996cited by this paper
• Cell Killing by the Drosophila Gene reaper

  1996cited by this paper
• Mammalian CAP interacts with CAP, CAP2, and actin

  1996cited by this paper
• Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE

  1994cited by this paper
• The human BAT3 ortholog in rodents is predominantly and developmentally expressedin testis

  1994cited by this paper
• Two interdependent basic domains in nucleoplasmin nuclear targeting sequence: identification of a class of bipartite nuclear targeting sequence.

  1991cited by this paper
• A gene pair from the human major histocompatibility complex encodes large proline-rich proteins with multiple repeated motifs and a single ubiquitin-like domain.

  1990cited by this paper
• Sequence requirements for nuclear location of simian virus 40 large-T antigen

  1984cited by this paper
• DNA sequencing with chain-terminating inhibitors.

  1977cited by this paper

• One BAG doesn't fit all: the differences and similarities of BAG family members in mediating CNS homeostasis.

  2025cites this paper
• Mouse Pxt1 expression is regulated by Mir6996 miRNA.

  2023cites this paper
• GET4 is a novel driver gene in colorectal cancer that regulates the localization of BAG6, a nucleocytoplasmic shuttling protein

  2021cites this paper
• PAQR9 modulates BAG6-mediated protein quality control of mislocalized membrane proteins.

  2020cites this paper
• HLA-B-associated transcript 3 (Bat3) stabilizes and activates p53 in a HAUSP-dependent manner

  2019cites this paper
• The Bag6 Complex: Biological Complexity through Modularity

  2017influential citation
• The structural basis for regulation of the nucleo-cytoplasmic distribution of Bag6 by TRC35

  2017cites this paper
• Structural basis for regulation of the nucleo-cytoplasmic distribution of Bag6 by TRC35

  2017influential citation
• mReg2 inhibits nuclear entry of apoptosis-inducing factor in mouse insulinoma cells

  2015cites this paper
• Possible Prognostic Value of BORIS Transcript Variants Ratio in Laryngeal Squamous Cell Carcinomas – a Pilot Study

  2014cites this paper
• Nucleocytoplasmic transport under stress conditions and its role in HSP70 chaperone systems.

  2014cites this paper
• SGTA regulates the cytosolic quality control of hydrophobic substrates

  2014cites this paper
• Overexpression of BAT3 Alleviates Prion Protein Fragment PrP106‐126‐Induced Neuronal Apoptosis

  2014cites this paper
• BAT3 modulates p300-dependent acetylation of p53 and autophagy-related protein 7 (ATG7) during autophagy

  2014cites this paper
• BAG6 regulates the quality control of a polytopic ERAD substrate

  2014influential citation
• Nuclear BAG6-UBL4A-GET4 Complex Mediates DNA Damage Signaling and Cell Death*

  2013cites this paper
• Bag6/Bat3/Scythe: A novel chaperone activity with diverse regulatory functions in protein biogenesis and degradation

  2013cites this paper
• BAG6/BAT3: emerging roles in quality control for nascent polypeptides.

  2013cites this paper
• BAG-6, a jack of all trades in health and disease

  2013cites this paper
• The Ubiquitin-like modifier FAT10 in tolerance induction

  2013cites this paper
• Bcl-2 associated athanogene 5 (Bag5) is overexpressed in prostate cancer and inhibits ER-stress induced apoptosis

  2013cites this paper
• IL1RAPL1 Associated with Mental Retardation and Autism Regulates the Formation and Stabilization of Glutamatergic Synapses of Cortical Neurons through RhoA Signaling Pathway

  2013cites this paper
• Scythe cleavage during Fas (APO‐1)‐and staurosporine‐mediated apoptosis

  2012cites this paper
• AIF and Scythe (Bat3) Regulate Phosphatidylserine Exposure and Macrophage Clearance of Cells Undergoing Fas (APO-1)-Mediated Apoptosis

  2012cites this paper
• BAT3 Regulates Mycobacterium tuberculosis Protein ESAT-6-Mediated Apoptosis of Macrophages

  2012cites this paper
• A Novel BAT3 Sequence Generated by Alternative RNA Splicing of Exon 11B Displays Cell Type-Specific Expression and Impacts on Subcellular Localization

  2012influential citation
• A Novel, Non-Apoptotic Role for Scythe/BAT3: A Functional Switch between the Pro- and Anti-Proliferative Roles of p21 during the Cell Cycle

  2012cites this paper
• 7‐Interferon‐regulated chaperone governs human lymphocyte antigen class II expression

  2012cites this paper
• BAT 3 Guides Misfolded Glycoproteins Out of the Endoplasmic Reticulum Citation Claessen

  2011cites this paper
• BAT3 Guides Misfolded Glycoproteins Out of the Endoplasmic Reticulum

  2011cites this paper
• Apoptosis-Inducing Factor: Structure, Function, and Redox Regulation

  2011cites this paper
• Overexpression of peroxisomal testis-specific 1 protein induces germ cell apoptosis and leads to infertility in male mice

  2011cites this paper
• The promoter for intestinal cell kinase is head-to-head with F-Box 9 and contains functional sites for TCF7L2 and FOXA factors

  2010cites this paper
• Bat3 promotes the membrane integration of tail-anchored proteins

  2010influential citation
• Sequential interplay between BAG6 and HSP70 upon heat shock

  2009cites this paper
• Growth inhibitory action of distinct sequences derived from the co-chaperone Bag-1L

  2009influential citation
• BAT3 Interacts with Transforming Growth Factor-β (TGF-β) Receptors and Enhances TGF-β1-induced Type I Collagen Expression in Mesangial Cells*

  2008cites this paper
• The BAG proteins: a ubiquitous family of chaperone regulators

  2008cites this paper
• HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53.

  2007influential citation
• Human leukocyte antigen-B-associated transcript 3 is released from tumor cells and engages the NKp30 receptor on natural killer cells.

  2007cites this paper
• Differential gene expression in a paclitaxel-resistant clone of a head and neck cancer cell line

  2006cites this paper
• Identification of Yin-Yang Regulators and a Phosphorylation Consensus for Male Germ Cell-Associated Kinase (MAK)-Related Kinase

  2006influential citation
• Phenotype-Based Identification of Host Genes Required for Replication of African Swine Fever Virus†

  2006cites this paper
• Human SGT interacts with Bag-6/Bat-3/Scythe and cells with reduced levels of either protein display persistence of few misaligned chromosomes and mitotic arrest.

  2006cites this paper
• Phenotype-Based Identification of Host Genes Required for Replication of African Swine Fever Virus

  2006cites this paper
• Drosophila starvin Encodes a Tissue-Specific BAG-Domain Protein Required for Larval Food Uptake

  2005cites this paper
• Mechanism of action of Drosophila Reaper in mammalian cells: Reaper globally inhibits protein synthesis and induces apoptosis independent of mitochondrial permeability

  2004cites this paper
• Apoptosis signaling to mitochondria by death receptors and DNA damaging anti-cancer regimens

  2004cites this paper
• Immediate early gene X-1 interacts with proteins that modulate apoptosis.

  2004cites this paper
• Ricin Triggers Apoptotic Morphological Changes through Caspase-3 Cleavage of BAT3*

  2004cites this paper
• Charakterisierung und Expression der MHC-kodierten BAT2- und BAT3-Gene

  2003cites this paper
• What's in the 'BAG'?--A functional domain analysis of the BAG-family proteins.

  2002cites this paper