Thematic Minireview Series on Glycobiology and Extracellular Matrices: Glycan Functions Pervade Biology at All Levels*

G. Hart

Published 2013 in Journal of Biological Chemistry

ABSTRACT

Abstract Glycans represent one of the four fundamental building blocks of life, and they are the most abundant biological molecules on our planet. Only in recent years, have we begun to appreciate how deeply glycan functions pervade all aspects of organismic biology, molecular biology and biochemistry. A recent National Academy Science report ( http://www.nap.edu/catalog.php?record_id=13446 ) has concluded that a better understanding of glycoscience is critical to advancing human health and for sustainability on this planet. The report further concludes that efforts to study this key area of biochemistry/biology have substantially lagged behind investments in other biological molecules, such as nucleic acids and proteins. The Journal of Biological Chemistry continues to be the leader in publication of glycoscience research. In this special issue of the Journal, five Mini-Reviews, authored by leaders in glycobiology, illustrate the remarkable diversity of the biological functions of glycans.

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