Dimethylnitrosamine-induced cirrhosis. Evidence for an immunological mechanism.

No abstract is available for this paper.

• Publication year

  1989

• Venue

  Journal of Hepatology

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/0168-8278(89)90160-8PMID 2921502
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Correlation between Ito cells and fibrogenesis in an experimental model of hepatic fibrosis. A sequential stereological study.

  2008cited by this paper
• A morphological study of the early stages of hepatic fibrosis induced by low doses of dimethylnitrosamine in the rat.

  1987cited by this paper
• Large granular lymphocytes or “Pit cells” from rat liver: isolation, ultrastructural characterization and natural killer activity

  1987cited by this paper
• Sequential changes of extracellular matrix and proliferation of Ito cells with enhanced expression of desmin and actin in focal hepatic injury.

  1986cited by this paper
• A dimethylnitrosamine-induced model of cirrhosis and portal hypertension in the rat.

  1985cited by this paper
• Ethanol and Fibrogenesis in the Liver

  1985cited by this paper
• Immunocytochemical Detection of Desmin in Fat‐Storing Cells (Ito Cells)

  1984cited by this paper
• Functional significance of the regulation of macrophage Ia expression

  1984cited by this paper
• The fine structure of normal lymphocyte subpopulations--a study with monoclonal antibodies and the immunogold technique.

  1982cited by this paper
• The extracellular matrix of the liver.

  1982cited by this paper
• Role of the Kupffer cells in local and systemic immune responses.

  1981cited by this paper
• Role of the Kupffer cells in local and systemic immune responses

  1981cited by this paper
• Antigen presentation by isolated guinea pig Kupffer cells.

  1980cited by this paper
• Intermediate filaments as mechanical integrators of cellular space

  1980cited by this paper
• Increased antibody production following depression of hepatic phagocytosis.

  1975cited by this paper

• Aluminum adjuvant promotes liver inflammation and fibrosis in mice: A novel approach to establish a liver fibrosis animal model

  2025cites this paper
• Protective Effect of Oligonol on Dimethylnitrosamine-Induced Liver Fibrosis in Rats via the JNK/NF-κB and PI3K/Akt/Nrf2 Signaling Pathways

  2021cites this paper
• Metabolism of N-nitrosodimethylamine, methylation of macromolecules, and development of hepatic fibrosis in rodent models

  2020cites this paper
• Molecular mechanisms in the pathogenesis of N-nitrosodimethylamine induced hepatic fibrosis

  2019cites this paper
• A new perspective in liver fibrosis: Etiology removal does not cause regression of liver fibrosis

  2018cites this paper
• Gallic Acid Attenuates Dimethylnitrosamine-Induced Liver Fibrosis by Alteration of Smad Phosphoisoform Signaling in Rats

  2018cites this paper
• Effect of Yi Guan Jian decoction on differentiation of bone marrow mesenchymalstem cells into hepatocyte-like cells in dimethylnitrosamine-induced liver cirrhosis in mice

  2016cites this paper
• Hepatoprotective effects of zingerone on carbon tetrachloride- and dimethylnitrosamine-induced liver injuries in rats

  2015cites this paper
• Quantitative changes in tumor-associated M2 macrophages characterize cholangiocarcinoma and their association with metastasis.

  2015cites this paper
• Two xanthones from Swertia punicea with hepatoprotective activities in vitro and in vivo.

  2014cites this paper
• Melatonin inhibits cholangiocarcinoma and reduces liver injury in Opisthorchis viverrini‐infected and N‐nitrosodimethylamine‐treated hamsters

  2013cites this paper
• Effect of sinapic acid against dimethylnitrosamine-induced hepatic fibrosis in rats

  2013cites this paper
• Modulation of extracellular matrix proteins and hepatate stellate cell activation following gadolinium chloride induced Kuffer cell blockade in an experimental model of liver fibrosis/cirrhosis

  2013cites this paper
• Ameliorative effect of silibinin against N-nitrosodimethylamine-induced hepatic fibrosis in rats.

  2012cites this paper
• Can apricot kernels fatty acids delay the atrophied hepatocytes from progression to fibrosis in dimethylnitrosamine (DMN)-induced liver injury in rats?

  2011cites this paper
• Induction of HGF and VEGF in hepatic regeneration after hepatotoxin-induced cirrhosis in mice.

  2011cites this paper
• Protective Effects of Cinnamomum cassia Blume in the Fibrogenesis of Activated HSC-T6 Cells and Dimethylnitrosamine-Induced Acute Liver Injury in SD Rats

  2010cites this paper
• Inhibitory Effect of 1-O-Hexyl-2,3,5-Trimethylhydroquinone on Dimethylnitrosamine-induced Liver Fibrosis in Male SD Rats

  2010cites this paper
• Effect of dietary supplementation of grape skin and seeds on liver fibrosis induced by dimethylnitrosamine in rats

  2010cites this paper
• The proanthocyanidins inhibit dimethylnitrosamine-induced liver damage in rats

  2010cites this paper
• Involvement of MMP‐9 in peribiliary fibrosis and cholangiocarcinogenesis via Rac1‐dependent DNA damage in a hamster model

  2010cites this paper
• Resveratrol inhibits dimethylnitrosamine-induced hepatic fibrosis in rats

  2010influential citation
• Targeted disruption of Smad3 confers resistance to the development of dimethylnitrosamine‐induced hepatic fibrosis in mice

  2009cites this paper
• Antifibrotic effects of green tea on in vitro and in vivo models of liver fibrosis.

  2009cites this paper
• Targeted disruption of Smad 3 confers resistance to the developmentof dimethylnitrosamine-induced hepatic ¢ brosis inmice

  2009cites this paper
• Anti-fibrotic effects of a methylenedioxybenzene compound, CW209292 on dimethylnitrosamine-induced hepatic fibrosis in rats.

  2009cites this paper
• Role of hepatic vitamin A and lipocyte distribution in experimental hepatic fibrosis.

  2008cites this paper
• Activity Change of Sphingomyelin Anabolic Enzymes during Dimethylnitrosamine-induced Hepatic Fibrosis in Rats

  2008cites this paper
• Immunohistochemical identification of proliferating cells following dimethylnitrosamine-induced liver injury.

  2008cites this paper
• Reduction of Liver Fibrosis by Xenogeneic Human Umbilical Cord Blood and Adipose Tissue-derived Multipotent Stem Cells without Treatment of an Immunosuppressant

  2008cites this paper
• Pathophysiological Characteristics of Dimethylnitrosamine-Induced Liver Fibrosis in Acute and Chronic Injury Models: A Possible Contribution of KLF5 to Fibrogenic Responses

  2008cites this paper
• Hepatoprotective effect of vitamin B12 on dimethylnitrosamine-induced liver injury.

  2008cites this paper
• Preventive effect of Qianggan-Rongxian Decoction on rat liver fibrosis.

  2008cites this paper
• Adenoviral vector expressing hepatocyte growth factor promotes liver regeneration by preoperative injection: the advantages of performing selective injection to the remnant lobe.

  2007cites this paper
• Iron deposition and fat accumulation in dimethylnitrosamine-induced liver fibrosis in rat.

  2007cites this paper
• Oncostatin M gene therapy attenuates liver damage induced by dimethylnitrosamine in rats.

  2007cites this paper
• Influence of somatostatin and octreotide on liver microcirculation in an experimental mouse model of cirrhosis studied by intravital fluorescence microscopy

  2007cites this paper
• Granulocyte colony-stimulating factor impairs liver regeneration in mice through the up-regulation of interleukin-1beta.

  2007cites this paper
• The hepatic stellate cell in sight

  2006cites this paper
• Combination gene therapy of HGF and truncated type II TGF-beta receptor for rat liver cirrhosis after partial hepatectomy.

  2006cites this paper
• Effects of bicyclol on dimethylnitrosamine-induced liver fibrosis in mice and its mechanism of action.

  2006cites this paper
• Increased iron deposition in rat liver fibrosis induced by a high-dose injection of dimethylnitrosamine.

  2006cites this paper
• The hepatic stellate cell in sight: targeting antiproliferative drugs to the fibrotic liver

  2006cites this paper
• Remote delivery and expression of soluble type II TGF-beta receptor in muscle prevents hepatic fibrosis in rats.

  2005cites this paper
• Cell cycle protein profile of the hepatic stellate cells (HSCs) in dimethylnitrosamine-induced rat hepatic fibrosis

  2005cites this paper
• Functional restoration of cirrhotic liver after partial hepatectomy in the rat.

  2005cites this paper
• Morphological and serum hyaluronic acid, laminin and type IV collagen changes in dimethylnitrosamine-induced hepatic fibrosis of rats.

  2005cites this paper
• Use of gene expression to characterize heterogeneous liver cell populations

  2004cites this paper
• An interleukin-1 receptor antagonist decreases fibrosis induced by dimethylnitrosamine in rat liver

  2004influential citation
• The flavonoid naringenin inhibits dimethylnitrosamine-induced liver damage in rats.

  2004cites this paper
• Anti-monocyte chemoattractant protein-1 gene therapy prevents dimethylnitrosamine-induced hepatic fibrosis in rats.

  2004cites this paper
• Chapter 24 – Possible Gene Therapy for Liver Cirrhosis

  2003cites this paper
• L-cysteine administration prevents liver fibrosis by suppressing hepatic stellate cell proliferation and activation.

  2003cites this paper
• Hepatocyte growth factor gene transfer into the liver via the portal vein using electroporation attenuates rat liver cirrhosis

  2003cites this paper
• Experimental studies on morphological changes of microcirculation of DMN‐induced liver cirrhosis after normothermic ischemia with charge‐coupled device microscope

  2003cites this paper
• The flavonoid quercetin inhibits dimethylnitrosamine‐induced liver damage in rats

  2003influential citation
• Effect of Sho-saiko-to extract on hepatic inflammation and fibrosis in dimethylnitrosamine induced liver injury rats.

  2002cites this paper
• Heparin accelerates liver regeneration following portal branch ligation in normal and cirrhotic rats with increased plasma hepatocyte growth factor levels.

  2002cites this paper
• Liver inflammatory cells, apoptosis, regeneration and stellate cell activation in non-alcoholic steatohepatitis.

  2001cites this paper
• Dimethyl sulfoxide inhibits dimethylnitrosamine-induced hepatic fibrosis in rats.

  2001cites this paper
• Pirfenidone Inhibits Dimethylnitrosamine‐Induced Hepatic Fibrosis In Rats

  2001cites this paper
• Effects of Octreotide on Intestinal Transit and Bacterial Translocation in Conscious Rats with Portal Hypertension and Liver Fibrosis

  2001cites this paper
• History, Heterogeneity, Developmental Biology, and Functions of Quiescent Hepatic Stellate Cells

  2001cites this paper
• A selective ROCK inhibitor, Y27632, prevents dimethylnitrosamine-induced hepatic fibrosis in rats.

  2001cites this paper
• Hepatic Blood Flow Regulation by Stellate Cells in Normal and Injured Liver

  2001cites this paper
• Dimethylnitrosamine-induced liver injury in rats: the early deposition of collagen.

  2001cites this paper
• Kinetics of macrophages, myofibroblasts and mast cells in carbon tetrachloride-induced rat liver cirrhosis.

  2000cites this paper
• [Experimental models of portal hypertension].

  2000cites this paper
• Immunohistochemical detection of collagen type III and IV in relation with transformation of Ito cells in liver sinusoids of patients with reactive biliary hepatitis.

  1999cites this paper
• Hepatocyte growth factor gene therapy of liver cirrhosis in rats

  1999cites this paper
• Hepatic stellate cells (Ito cells) but not collagen IV may partly be responsible for lower portal pressure after reversing secondary biliary cirrhosis in the rat.

  1997cites this paper
• Morphology of liver stellate cells and liver vitamin A content in 3,4,3',4'-tetrachlorobiphenyl-treated rats.

  1997cites this paper
• Glial fibrillary acidic protein as a marker of perisinusoidal stellate cells that can distinguish between the normal and myofibroblast‐like phenotypes

  1996cites this paper
• Glycoprotein metabolism in dimethyinitrosan ne induced hepatic fibrosis in rats

  1996cites this paper
• Glycoprotein metabolism in dimethylnitrosamine induced hepatic fibrosis in rats.

  1996cites this paper
• Molecular characteristics of dimethylnitrosamine induced fibrotic liver collagen.

  1996cites this paper
• Tumoricidal response of liver macrophages isolated from rats bearing liver metastases of colon adenocarcinoma

  1995cites this paper
• Methylprednisolone does not inhibit the nonparenchymal cell responses to dimethylnitrosamine-induced liver injury

  1995cites this paper
• Hepatic ito cells contain calcium channels: Increases with transforming growth factor‐β 1

  1994cites this paper
• Prevalence of chronic liver disease in the general population of northern Italy: The dionysos study

  1994cites this paper
• In vivo responses of macrophages and perisinusoidal cells to cholestatic liver injury.

  1993cites this paper
• Morphologic Investigation of Sinusoidal Cells

  1993cites this paper
• Alterations in mitochondrial function and morphology in chronic liver disease: pathogenesis and potential for therapeutic intervention.

  1993cites this paper
• Phenotypic modulation of perisinusoidal cells following acute liver injury: a quantitative analysis.

  1992cites this paper
• Role of mesenchymal cell populations in porcine serum‐induced rat liver fibrosis

  1992cites this paper
• Immunolocalization of proliferating perisinusoidal cells in rat liver

  1992cites this paper
• Quantitative analysis of proliferating sinusoidal cells in dimethylnitrosamine-induced cirrhosis. An immunohistochemical study.

  1992cites this paper
• Macrophage and perisinusoidal cell kinetics in acute liver injury

  1992cites this paper
• Tissue distribution, quantitation and proliferation kinetics of fat‐storing cells in carbon tetrachloride–injured rat liver

  1991cites this paper
• Role of fat-storing cells in hepatic fibrogenesis. Retinoids as possible therapeutic agents.

  1991cites this paper
• Animal Models of Portal Hypertension

  1991cites this paper
• Phenotypic analysis of inflammatory infiltrate in rats with dimethylnitrosamine-induced cirrhosis.

  1991cites this paper
• Modulation of extracellular matrix components during dimethylnitrosamine-induced cirrhosis.

  1990cites this paper