Protein Phosphatase X Interacts with c-Rel and Stimulates c-Rel/Nuclear Factor κB Activity*

Nuclear factor κB (NF-κB) and the Rel family of proteins are pleiotropic transcription factors that play central roles in the immune and inflammatory responses, as well as apoptosis. Here, we identified a serine/threonine protein phosphatase X (PPX; also called protein phosphatase 4 (PP4)) that specifically associated with c-Rel, NF-κB p50, and RelA. The amino acid sequences of human and mouse PPX are 100% identical, and the PPX gene was mapped to human chromosome 16 p11.2. Overexpression of PPX, but not catalytically inactive PPX mutants, stimulated the DNA-binding activity of c-Rel and activated NF-κB-mediated transcription. These results suggest that PPX is a novel activator of c-Rel/NF-κB.

• Publication year

  1998

• Venue

  Journal of Biological Chemistry

• Publication date

  1998-12-11

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1074/JBC.273.50.33561PMID 9837938
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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