Diabetes Mellitus and Periodontitis: Signs of a Bidirectional Relationship

Periodontitis is a multifactorial, irreversible and cumulative condition, initiated and propagated by bacteria and host factors. The multifactorial nature of periodontitis is related with the complex interactions between microorganisms in the microbial dental plaque and host response mechanisms, as well as environmental factors. Progression of periodontal disease is very much dependent on host response. Diabetes mellitus (DM), a complex metabolic disorder characterised by prolonged hyperglycaemia, has long been recognised as one of the leading causes of morbidity and mortality globally. DM is a complex metabolic syndrome that affects both the quality and length of life with major complications. Periodontal disease and diabetes are highly prevalent chronic diseases and inflammation may play a critical role in their relationship. Prospective clinical studies with larger scale and greater statistical power are required to better clarify the mechanisms of possible effects of chronic periodontitis on diabetes.

• Publication year

  2013

• Venue

  EMJ Diabetes

• Publication date

  2013-11-28

• Fields of study

  Not labeled

• Identifiers
  DOI 10.33590/emjdiabet/10310009
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Association of stem cell factor and high-sensitivity C reactive protein concentrations in crevicular fluid and serum in patients with chronic periodontitis with and without type 2 diabetes.

  2013cited by this paper
• A review of the evidence for pathogenic mechanisms that may link periodontitis and diabetes.

  2013cited by this paper
• Diabetes and periodontal diseases: consensus report of the Joint EFP/AAP Workshop on Periodontitis and Systemic Diseases.

  2013cited by this paper
• Effect of gingival application of melatonin on alkaline and acid phosphatase, osteopontin and osteocalcin in patients with diabetes and periodontal disease

  2013cited by this paper
• Gingival crevicular fluid levels of human beta-defensins 1 and 3 in subjects with periodontitis and/or type 2 diabetes mellitus: a cross-sectional study.

  2013cited by this paper
• Evidence that periodontal treatment improves diabetes outcomes: a systematic review and meta-analysis.

  2013cited by this paper
• Gingival crevicular fluid adrenomedullin level in individuals with and without diabetes mellitus type 2.

  2013cited by this paper
• Association of serum and crevicular visfatin levels in periodontal health and disease with type 2 diabetes mellitus.

  2012cited by this paper
• The relationship of periodontal disease severity to serum and GCF substance P levels in diabetics.

  2012cited by this paper
• Expression of toll-like receptors 2, 4 and 9 is increased in gingival tissue from patients with type 2 diabetes and chronic periodontitis.

  2012cited by this paper
• Study of Health in Pomerania (SHIP)

  2012cited by this paper
• Lipid peroxidation is associated with the severity of periodontal disease and local inflammatory markers in patients with type 2 diabetes.

  2012cited by this paper
• The expression of antioxidant enzymes in the gingivae of type 2 diabetics with chronic periodontitis.

  2012cited by this paper
• Activity of neutrophil β-glucuronidase in diabetic and nondiabetic patients with chronic generalized periodontitis and healthy subjects.

  2011cited by this paper
• Diagnosis and Classification of Diabetes Mellitus

  2011cited by this paper
• Inflammatory cytokines, adiponectin, insulin resistance and metabolic control after periodontal intervention in patients with type 2 diabetes and chronic periodontitis.

  2011cited by this paper
• Salivary IgA and periodontal treatment needs in diabetic patients.

  2011cited by this paper
• Adipokines and inflammatory mediators after initial periodontal treatment in patients with type 2 diabetes and chronic periodontitis.

  2010cited by this paper
• Receptor activator of nuclear factor-kappa B ligand/osteoprotegerin ratio in sites of chronic periodontitis of subjects with poorly and well-controlled type 2 diabetes.

  2010cited by this paper
• Oral health: prevention is key.

  2009cited by this paper
• Salivary antioxidants in patients with type 1 or 2 diabetes and inflammatory periodontal disease: a case-control study.

  2009cited by this paper
• The effect of non-surgical periodontal therapy on peroxidase activity in diabetic patients: a case-control pilot study.

  2008cited by this paper
• Effects of periodontal therapy on glycemic control and inflammatory markers.

  2008cited by this paper
• Clinical and laboratory evaluations of non-surgical periodontal treatment in subjects with diabetes mellitus.

  2008cited by this paper
• Relationship between markers of metabolic control and inflammation on severity of periodontal disease in patients with diabetes mellitus.

  2007cited by this paper
• Gingival crevicular fluid interleukin-1beta, prostaglandin E2 and periodontal status in a community population.

  2007cited by this paper
• The periodontal host response with diabetes.

  2007cited by this paper
• Effect of non-surgical periodontal therapy on clinical and immunological response and glycaemic control in type 2 diabetic patients with moderate periodontitis.

  2007cited by this paper
• Effects of Diabetes Mellitus, Chronic Renal Failure and Hemodialysis on Serum and Salivary Antioxidant Status

  2006cited by this paper
• Clustering of insulin resistance with vascular dysfunction and low-grade inflammation in type 2 diabetes.

  2006cited by this paper
• Parameters of oxidative stress in saliva from diabetic and parenteral drug addict patients.

  2006cited by this paper
• The effect of improved periodontal health on metabolic control in type 2 diabetes mellitus.

  2005cited by this paper
• Circulating adiponectin levels are associated with better glycemic control, more favorable lipid profile, and reduced inflammation in women with type 2 diabetes.

  2005cited by this paper
• Cross-sectional analysis of different variables of patients with non-insulin dependent diabetes and their periodontal status.

  2004cited by this paper
• The investigation of glutathione peroxidase, lactoferrin, myeloperoxidase and interleukin-1beta in gingival crevicular fluid: implications for oxidative stress in human periodontal diseases.

  2004cited by this paper
• Gingival crevicular fluid levels of interleukin-1beta and glycemic control in patients with chronic periodontitis and type 2 diabetes.

  2004cited by this paper
• Role of smoking and HbA1c level in periodontitis among insulin-dependent diabetic patients.

  2003cited by this paper
• The systemic immune response is more prominent than the mucosal immune response in the pathogenesis of periodontal disease.

  2003cited by this paper
• The influence of diabetes on the periodontal tissues.

  2003cited by this paper
• Dental problems in patients with diabetes mellitus (II): gingival index and periodontal disease.

  2003cited by this paper
• Diabetes mellitus: a review of the literature and dental implications.

  2001cited by this paper
• The effect of antimicrobial periodontal treatment on circulating tumor necrosis factor-alpha and glycated hemoglobin level in patients with type 2 diabetes.

  2001cited by this paper
• The effect of periodontal treatment on glycemic control in patients with type 2 diabetes mellitus.

  2001cited by this paper
• Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study

  2000cited by this paper
• Chronic subclinical inflammation as part of the insulin resistance syndrome: the Insulin Resistance Atherosclerosis Study (IRAS).

  2000cited by this paper
• Heightened gingival inflammation and attachment loss in type 2 diabetics with hyperlipidemia.

  1999cited by this paper
• Dental self-efficacy as a determinant to oral health behaviour, oral hygiene and HbA1c level among diabetic patients.

  1999cited by this paper
• Healing response to non-surgical periodontal therapy in patients with diabetes mellitus: clinical, microbiological, and immunologic results.

  1998cited by this paper
• Periodontal findings in elderly patients with non-insulin dependent diabetes mellitus.

  1998cited by this paper
• Importance of glucose control.

  1998cited by this paper
• Non-insulin dependent diabetes mellitus and alveolar bone loss progression over 2 years.

  1998cited by this paper
• Monocytic TNF alpha secretion patterns in IDDM patients with periodontal diseases.

  1997cited by this paper
• Inflammatory mediator response as a potential risk marker for periodontal diseases in insulin-dependent diabetes mellitus patients.

  1997cited by this paper
• Vascular homeostasis, adhesion molecules, and macrovascular disease in non‐insulin‐dependent diabetes mellitus

  1997cited by this paper
• Increased circulating intercellular adhesion molecule-1 levels in type II diabetic patients: the possible role of metabolic control and oxidative stress.

  1996cited by this paper
• Endotoxin and cytokines induce expression of leptin, the ob gene product, in hamsters.

  1996cited by this paper
• Elevated circulating adhesion molecules in NIDDM — potential mediators in diabetic macroangiopathy

  1996cited by this paper
• Antioxidant activity of saliva and periodontal disease.

  1994cited by this paper
• Fructosamine as a possible monitoring parameter in non-insulin dependent diabetes mellitus patients with periodontal disease.

  1993cited by this paper
• Periodontal Disease: The sixth complication of diabetes mellitus

  1993cited by this paper
• Periodontal conditions in insulin-dependent diabetes mellitus.

  1992cited by this paper
• Receptor-Mediated Interactions of Advanced Glycosylation End Products With Cellular Components Within Diabetic Tissues

  1992cited by this paper
• Periodontal disease in non-insulin-dependent diabetes mellitus.

  1991cited by this paper
• Rapid periodontal destruction in adult humans with poorly controlled diabetes. A report of 2 cases.

  1990cited by this paper
• Prevalence of periodontal disease in insulin-dependent diabetes mellitus (juvenile diabetes).

  1982cited by this paper

• The Severity of Periodontitis in Elderly Patients with Type 2 Diabetes Mellitus: A Community-Based Study

  2024cites this paper
• The Role of Type-2 Diabetes Mellitus in the Progressivity of Periodontitis Stage IV Grade C: A Case Report

  2022cites this paper
• Diabetes Mellitus and Periodontitis: Bidirectional Relationship

  2021cites this paper
• THE BACTERIUM Fusobacterium sp. MAY INTERFERE WITH CONCEPTION

  2020influential citation
• Patients’ Understanding of the Relationship Between Their Diabetes and Periodontal Disease

  2020cites this paper
• Effectiveness of Chitosan Solution as Denture Cleanser to Inhibit the Growth of Candida albicans on Acrylic, Valplast and Luciton-FRS

  2019cites this paper
• Effect of NonSurgical Periodontal Therapy on Plasma Levels of IL-17 in Chronic Periodontitis Patients with Well Controlled Type-II Diabetes Mellitus—A Clinical Study

  2018cites this paper
• Effects of Systemic Simvastatin on the Concentrations of Visfatin, Tumor Necrosis Factor-α, and Interleukin-6 in Gingival Crevicular Fluid in Patients with Type 2 Diabetes and Chronic Periodontitis

  2018cites this paper
• Effect of Periodontal Intervention on Metabolic Control of Diabetes Mellitus

  2017influential citation
• Type II diabetes mellitus, periodontitis and their association with IL-23

  2017cites this paper
• Isolation, Characterization and Estimation of Ellagic Acid activity against Porphyromonas gingivalis Isolated from adult Periodontitis Patients in Kerbala City

  2017cites this paper
• Estimation of Some Cytokines in Serum and Gingival Fluid in Diabetic Patients with Peridontitis

  2015cites this paper
• RELATIONSHIP OF DIABETES AND PERIODONTITIS: A REVIEW

  2015cites this paper
• Salivary IL-1beta in diabetic patients with periodontitis, and healthy subjects with periodontitis

  2015cites this paper
• Cellular microenvironment and collagen destruction during periodont inflammation

  2015cites this paper