Mechanisms for 2‐methoxyestradiol‐induced apoptosis of prostate cancer cells

No abstract is available for this paper.

• Publication year

  2002

• Venue

  FEBS Letters

• Publication date

  2002-11-06

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/S0014-5793(02)03478-6PMID 12417302
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2001cited by this paper
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  2000cited by this paper
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  2000cited by this paper
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  2000cited by this paper
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  2000cited by this paper
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  2000cited by this paper
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  2000cited by this paper
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  1999cited by this paper
• Potent antitumor activity of 2-methoxyestradiol in human pancreatic cancer cell lines.

  1999cited by this paper
• Prognostic significance of apoptosis regulators in breast cancer.

  1999cited by this paper
• Overcoming bcl-2- and p53-mediated resistance in prostate cancer.

  1999cited by this paper
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  1999cited by this paper
• c-Jun N-terminal kinase mediates apoptotic signaling induced by N-(4-hydroxyphenyl)retinamide.

  1999cited by this paper
• Is 2-methoxyestradiol an endogenous estrogen metabolite that inhibits mammary carcinogenesis?

  1998cited by this paper
• Microtubule-interfering Agents Activate c-Jun N-terminal Kinase/Stress-activated Protein Kinase through Both Ras and Apoptosis Signal-regulating Kinase Pathways*

  1998cited by this paper
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  1998cited by this paper
• 2-Methoxyestradiol-induced phosphorylation of Bcl-2: uncoupling from JNK/SAPK activation.

  1998cited by this paper
• SAPKs and transcription factors do the nucleocytoplasmic tango.

  1998cited by this paper
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  1998cited by this paper
• Angiotensin Type 2 Receptor Dephosphorylates Bcl-2 by Activating Mitogen-activated Protein Kinase Phosphatase-1 and Induces Apoptosis*

  1997cited by this paper
• Induction of apoptosis in human lung cancer cells after wild-type p53 activation by methoxyestradiol

  1997cited by this paper
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  1997cited by this paper
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  1997cited by this paper
• Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance

  1997cited by this paper
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  1997cited by this paper
• Regulation of transcription by MAP kinase cascades.

  1996cited by this paper
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  1996cited by this paper
• Taxol induces bcl-2 phosphorylation and death of prostate cancer cells.

  1996cited by this paper
• Estrogen induces apoptosis in a rat prostatic adenocarcinoma: Association with an increased expression of TGF‐ β1 and its type‐I and type‐II receptors

  1996cited by this paper
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  1996cited by this paper
• Cancer statistics, 1996

  1996cited by this paper
• Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis

  1995cited by this paper
• Heterotrimeric G proteins: organizers of transmembrane signals.

  1995cited by this paper
• Inactivation of Bcl-2 by phosphorylation.

  1995cited by this paper
• Bcl-2 protein expression and long-term survival in breast cancer.

  1994cited by this paper
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  1994cited by this paper
• MAPKs: new JNK expands the group.

  1994cited by this paper
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  1994cited by this paper
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  1994cited by this paper
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  1994cited by this paper
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  1994cited by this paper
• The diagnosis of prostatic carcinoma

  1993cited by this paper
• Investigation of the subcellular distribution of the bcl-2 oncoprotein: residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membranes.

  1993cited by this paper
• Detection of the apoptosis-suppressing oncoprotein bc1-2 in hormone-refractory human prostate cancers.

  1993cited by this paper
• Apoptosis and the regulation of cell numbers in normal and neoplastic tissues: an overview

  1992cited by this paper
• Effects of 17β-Estradiol Metabolites on Cell Cycle Events in MCF-7 Cells

  1992cited by this paper
• Effects of 17 beta-estradiol metabolites on cell cycle events in MCF-7 cells.

  1992cited by this paper
• Expression of the protooncogene bcl-2 in the prostate and its association with emergence of androgen-independent prostate cancer.

  1992cited by this paper
• Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

  1990cited by this paper
• Development and characteristics of the available animal model systems for the study of prostatic cancer.

  1987cited by this paper
• Clustering of breakpoints on chromosome 11 in human B-cell neoplasms with the t(11 ; 14) chromosome translocation

  1985cited by this paper
• A detergent-trypsin method for the preparation of nuclei for flow cytometric DNA analysis.

  1983cited by this paper
• Structure-activity relationships for activation of adenylate cyclase by the diterpene forskolin and its derivatives.

  1983cited by this paper
• Comparative properties of the catechol estrogens, I: methylation by catechol-O-methyltransferase and binding to cytosol estrogen receptors.

  1980cited by this paper
• Transplacental carcinogenesis by stilbestrol.

  1971cited by this paper
• Tumor angiogenesis: therapeutic implications.

  1971cited by this paper

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  2017cites this paper
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  2017cites this paper
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  2016cites this paper
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  2015cites this paper
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  2015influential citation
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  2015cites this paper
• Potential Role of Estrogen Metabolite 2-Methoxyestradiol in Health and Disease

  2014cites this paper
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  2014cites this paper
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• Cell cycle regulation of human foreskin fibroblasts

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  2009influential citation
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  2006cites this paper
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  2006cites this paper
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  2005cites this paper
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  2005cites this paper
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  2005influential citation
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  2005cites this paper
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  2004cites this paper
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  2004cites this paper
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  2004cites this paper
• [Therapeutic implications of the revised concept of hormone-refractory metastatic prostate cancer].

  2004cites this paper
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  2004cites this paper
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  2004cites this paper
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  2003cites this paper
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  2003cites this paper
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