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Updating temporal expectancy of an aversive event engages striatal plasticity under amygdala control

G. Dallérac,Michael Graupner,J. Knippenberg,R. Martinez,T. F. Tavares,Lucille Tallot,Nicole el Massioui,Anna Verschueren,Sophie Höhn,J. B. Bertolus,A. Reyes,Joseph E LeDoux,G. Schafe,Lorenzo Díaz-Mataix,V. Doyère

Published 2017 in Nature Communications

ABSTRACT

Pavlovian aversive conditioning requires learning of the association between a conditioned stimulus (CS) and an unconditioned, aversive stimulus (US) but also involves encoding the time interval between the two stimuli. The neurobiological bases of this time interval learning are unknown. Here, we show that in rats, the dorsal striatum and basal amygdala belong to a common functional network underlying temporal expectancy and learning of a CS–US interval. Importantly, changes in coherence between striatum and amygdala local field potentials (LFPs) were found to couple these structures during interval estimation within the lower range of the theta rhythm (3–6 Hz). Strikingly, we also show that a change to the CS–US time interval results in long-term changes in cortico-striatal synaptic efficacy under the control of the amygdala. Collectively, this study reveals physiological correlates of plasticity mechanisms of interval timing that take place in the striatum and are regulated by the amygdala. Aversive conditioning requires the learning of time intervals between conditioned and unconditioned stimuli, as well as the associations of the stimuli themselves. Here the authors show that dorsal striatum and basal amygdala are part of a functional network that encodes interval timing.

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