Paraneoplastic erythrocytosis associated with an inactivating point mutation of the von Hippel-Lindau gene in a renal cell carcinoma.

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Blood

• Publication date

  2002-05-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1182/BLOOD.V99.10.3562PMID 11986208
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Independent function of two destruction domains in hypoxia‐inducible factor‐α chains activated by prolyl hydroxylation

  2001cited by this paper
• Contrasting effects on HIF-1alpha regulation by disease-causing pVHL mutations correlate with patterns of tumourigenesis in von Hippel-Lindau disease.

  2001cited by this paper
• Constitutive activation of hypoxia-inducible genes related to overexpression of hypoxia-inducible factor-1alpha in clear cell renal carcinomas.

  2001cited by this paper
• HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O2 Sensing

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• Pathogenetic mechanisms of polycythemia vera and congenital polycythemic disorders.

  2001cited by this paper
• Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O2-Regulated Prolyl Hydroxylation

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• The von Hippel-Lindau tumor suppressor protein.

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• Up-regulation of hypoxia-inducible factors HIF-1α and HIF-2α under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss of function

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• Hypoxia-inducible expression of tumor-associated carbonic anhydrases.

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• Erythropoietin stimulates proliferation of human renal carcinoma cells.

  2000cited by this paper
• Up-regulation of hypoxia-inducible factors HIF-1alpha and HIF-2alpha under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss of function.

  2000cited by this paper
• The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

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• Gene expression of erythropoietin in renal cell carcinoma.

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• Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1.

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• Synthetic peptides define critical contacts between elongin C, elongin B, and the von Hippel-Lindau protein.

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• Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function.

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• Software and database for the analysis of mutations in the VHL gene

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• Induction of endothelial PAS domain protein-1 by hypoxia: characterization and comparison with hypoxia-inducible factor-1alpha.

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• Prevalence of paraneoplastic erythropoietin production by renal cell carcinomas

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• Identification of the renal erythropoietin-producing cells using transgenic mice.

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• Co-localization of erythropoietin mRNA and ecto-5'-nucleotidase immunoreactivity in peritubular cells of rat renal cortex indicates that fibroblasts produce erythropoietin.

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• Erythropoietin in renal cell carcinoma: evaluation of its usefulness as a tumor marker.

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• New human renal carcinoma cell line established from a patient with erythrocytosis.

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• Renal cell carcinoma.

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• Medicine

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• Multidisciplinary management of patients diagnosed with von Hippel-Lindau disease: A practical review of the literature for clinicians

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• 67-Year-Old Man With Fatigue, Lightheadedness, and Erythrocytosis.

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• Erythropoietin-producing clear cell renal cell carcinoma associated with secondary polycythemia

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• Hemangioblastoma: Sporadic Cases and Von Hippel-Lindau's Disease: About 4 Cases and Literature Review

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• Von Hippel–Lindau disease: a single gene, several hereditary tumors

  2017influential citation
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• CONGENITAL ERYTHROCYTOSIS ARE RARE DISORDERS WITH MANY GENES INVOLVED. FUNCTIONAL EVALUATION OF NOVEL PHD2 AND EPOR MUTATIONS.

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  2015cites this paper
• Regulation of Cellular Oxygen Sensing Pathways by VHL

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• E2-EPF UCP regulates stability and functions of missense mutant pVHL via ubiquitin mediated proteolysis

  2015influential citation
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• 34 – Disorders of Blood Cell Production in Clinical Oncology

  2014cites this paper
• Paraneoplastic symptoms: cachexia, polycythemia, and hypercalcemia are, respectively, related to vascular endothelial growth factor (VEGF) expression in renal clear cell carcinoma.

  2013cites this paper
• Paraneoplastic hormones: parathyroid hormone-related protein (PTHrP) and erythropoietin (EPO) are related to vascular endothelial growth factor (VEGF) expression in clear cell renal cell carcinoma

  2013cites this paper
• Hematopoiesis and the Kidney

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• polycythemia Mutations in the VHL gene in sporadic apparently congenital

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• Functional significance of erythropoietin in renal cell carcinoma

  2013influential citation
• The VHL-HIF Signaling in Renal Cell Carcinoma: Promises and Pitfalls

  2012influential citation
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  2012cites this paper
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• 3 The VHL-HIF Signaling in Renal Cell Carcinoma : Promises and Pitfalls

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