A quantitative study of white matter hypomyelination and oligodendroglial maturation in focal cortical dysplasia type II

Caterina Shepherd,Joan Y. W. Liu,J. Goc,L. Martinian,T. Jacques,S. Sisodiya,M. Thom

Published 2013 in Epilepsia

ABSTRACT

A diagnostic feature of focal cortical dysplasia (FCD) type II on magnetic resonance imaging (MRI) is increased subcortical white matter (WM) signal on T2 sequences corresponding to hypomyelination, the cause of which is unknown. We aimed to quantify WM pathology in FCD type II and any deficiency in the numbers and differentiation of oligodendroglial (OL) cell types within the dysplasia.

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