Weight of the Evidence Evaluation of Low-Dose Reproductive and Developmental Effects of Bisphenol A

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Human and Ecological Risk Assessment: An International Journal

• Publication date

  2004-10-01

• Fields of study

  Biology, Medicine, Environmental Science, Psychology

• Identifiers
  DOI 10.1080/10807030490513883
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Metabolism of bisphenol a in primary cultured hepatocytes from mice, rats, and humans.

  2002cited by this paper
• Low-dose bisphenol A does not affect reproductive organs in estrogen-sensitive C57BL/6N mice exposed at the sexually mature, juvenile, or embryonic stage.

  2002influential reference
• Low-dose in utero effects of xenoestrogens in mice and their relevance to humans: an analytical review of the literature.

  2002cited by this paper
• Summary of the National Toxicology Program's report of the endocrine disruptors low-dose peer review.

  2002cited by this paper
• Opinion of the Scientific Committee on Food on Bisphenol A

  2002cited by this paper
• Evaluation of the adequacy of published studies of low-dose effects of bisphenol A on the rodent prostate for use in human risk assessment.

  2002cited by this paper
• Normal sexual development of two strains of rat exposed in utero to low doses of bisphenol A.

  2002influential reference
• Carcinogenicity bioassay of bisphenol A.

  2002cited by this paper
• Metabolism and kinetics of bisphenol a in humans at low doses following oral administration.

  2002cited by this paper
• Three-generation reproductive toxicity study of dietary bisphenol A in CD Sprague-Dawley rats.

  2002influential reference
• An evaluation of the possible carcinogenicity of bisphenol A to humans.

  2002influential reference
• Exposure to bisphenol A during the fetal and suckling periods disrupts sexual differentiation of the locus coeruleus and of behavior in the rat.

  2001influential reference
• Genetic variation in physiological sensitivity to estrogen in mice

  2001cited by this paper
• In Utero Exposure to Bisphenol A Alters the Development and Tissue Organization of the Mouse Mammary Gland

  2001influential reference
• Statistical issues in the analysis of low-dose endocrine disruptor data.

  2001cited by this paper
• Potential estrogenic effects of bisphenol-A estimated by in vitro and in vivo combination assays.

  2001cited by this paper
• Carcinogenicity bioassays of bisphenol A, 4-vinylcyclohexene diepoxide, and 4-vinycyclohexene.

  2001cited by this paper
• THE ANNAPOLIS ACCORDS ON THE USE OF TOXICOLOGY IN RISK ASSESSMENT AND DECISION-MAKING: AN ANNAPOLIS CENTER WORKSHOP REPORT

  2001cited by this paper
• Prenatal Exposure to Low Doses of Bisphenol A Alters the Periductal Stroma and Glandular Cell Function in the Rat Ventral Prostate1

  2001cited by this paper
• In Vitro and in Vivo Interactions of Bisphenol A and Its Metabolite, Bisphenol A Glucuronide, with Estrogen Receptors α and β

  2001cited by this paper
• Rat two-generation reproductive toxicity study of bisphenol A.

  2001influential reference
• Bisphenol‐A Affects Spermatogenesis in the Adult Rat Even at a Low Dose

  2001influential reference
• In vitro and in vivo interactions of bisphenol A and its metabolite, bisphenol A glucuronide, with estrogen receptors alpha and beta.

  2001cited by this paper
• Altered prostate growth and daily sperm production in male mice exposed prenatally to subclinical doses of 17alpha-ethinyl oestradiol.

  2001cited by this paper
• Effect of different sampling designs on outcome of endocrine disruptor studies.

  2000cited by this paper
• The peripubertal male rat assay as an alternative to the Hershberger castrated male rat assay for the detection of anti‐androgens, oestrogens and metabolic modulators

  2000cited by this paper
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  2000cited by this paper
• The relative bioavailability and metabolism of bisphenol A in rats is dependent upon the route of administration.

  2000cited by this paper
• Reproductive malformation of the male offspring following maternal exposure to estrogenic chemicals.

  2000influential reference
• Uterotrophic activity of bisphenol A in the immature mouse.

  2000influential reference
• Getting the problem of endocrine disruption into focus: The need for a pause for thought

  2000cited by this paper
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  2000cited by this paper
• Developmental Exposure to Bisphenol A: Interaction with Endogenous Estradiol During Pregnancy in Mice1

  2000cited by this paper
• Strain differences in vaginal responses to the xenoestrogen bisphenol A.

  2000cited by this paper
• Estrogenic activity of octylphenol, nonylphenol, bisphenol A and methoxychlor in rats.

  2000cited by this paper
• Passage of Bisphenol A into the Fetus of the Pregnant Rat

  1999cited by this paper
• Environmental toxins: Exposure to bisphenol A advances puberty

  1999influential reference
• Normal reproductive organ development in Wistar rats exposed to bisphenol A in the drinking water.

  1999influential reference
• Fetal hepatic drug elimination.

  1999cited by this paper
• Lack of effects for low dose levels of bisphenol A and diethylstilbestrol on the prostate gland of CF1 mice exposed in utero.

  1999influential reference
• Prostate gland growth during development is stimulated in both male and female rat fetuses by intrauterine proximity to female fetuses.

  1999cited by this paper
• Normal reproductive organ development in CF-1 mice following prenatal exposure to bisphenol A.

  1999influential reference
• Genetic variation in susceptibility to endocrine disruption by estrogen in mice.

  1999influential reference
• Glucuronidation in Humans

  1999cited by this paper
• Dose levels of 0.01-0.2 microg/kg/day diethylstilbestrol are not suitable for use as a positive control in endocrine toxicity studies.

  1999cited by this paper
• Bisphenol A interacts with the estrogen receptor alpha in a distinct manner from estradiol.

  1998influential reference
• The xenoestrogen bisphenol A induces growth, differentiation, and c-fos gene expression in the female reproductive tract.

  1998cited by this paper
• A Physiologically Based Approach To the Study of Bisphenol a and Other Estrogenic Chemicals On the Size of Reproductive Organs, Daily Sperm Production, and Behavior

  1998influential reference
• Uterotrophic activity of bisphenol A in the immature rat.

  1998cited by this paper
• Relative binding affinity-serum modified access (RBA-SMA) assay predicts the relative in vivo bioactivity of the xenoestrogens bisphenol A and octylphenol.

  1997influential reference
• Development of a Tier I screening battery for detecting endocrine-active compounds (EACs).

  1997cited by this paper
• Evaluation of a recombinant yeast cell estrogen screening assay.

  1997influential reference
• Prostate enlargement in mice due to fetal exposure to low doses of estradiol or diethylstilbestrol and opposite effects at high doses.

  1997cited by this paper
• Profound effects of the weak environmental estrogen-like chemical bisphenol A on the growth of the mammary gland of Noble rats.

  1997cited by this paper
• Risk vs Risk: Tradeoffs in Protecting Health and the Environment

  1996cited by this paper
• Environmental estrogens: effects on cholesterol lowering and bone in the ovariectomized rat.

  1996cited by this paper
• Fertility in men exposed prenatally to diethylstilbestrol.

  1995cited by this paper
• The anogenital distance index, a predictor of the intrauterine position effects on reproduction in female house mice.

  1995cited by this paper
• The anogenital distance index, a predictor of the intrauterine position effects on reproduction in female house mice.

  1995cited by this paper
• Physiological responses to social status and housing conditions in male mice subject to food competition tests

  1993influential reference
• Bisphenol-A: an estrogenic substance is released from polycarbonate flasks during autoclaving.

  1993cited by this paper
• Changing cytokeratin expression patterns in diethylstilbestrol dipropionate-induced metaplastic lesions of the goat prostate.

  1992cited by this paper
• Effects of prenatal exposure to diethylstilbestrol (DES) on hemispheric laterality and spatial ability in human males.

  1992cited by this paper
• Anogenital distance at birth as a predictor of volume of the sexually dimorphic nucleus of the preoptic area of the hypothalamus and pituitary responsiveness in castrated adult rats.

  1992cited by this paper
• Intrauterine position effects on steroid metabolism and steroid receptors of reproductive organs in male mice.

  1992influential reference
• Developmental oestrogenization and prostatic neoplasia.

  1990cited by this paper
• Integrated risk information system (IRIS)

  1990cited by this paper
• Reference dose (RfD): description and use in health risk assessments.

  1988cited by this paper
• Effects of zeranol on reproduction in beef bulls: scrotal circumference, serving ability, semen characteristics, and pathologic changes of the reproductive organs.

  1987cited by this paper
• Males exposed in utero to diethylstilbestrol.

  1984cited by this paper
• Neoplastic and preneoplastic lesions induced in female C3H mice by diets containing diethylstilbestrol or 17 beta-estradiol.

  1980cited by this paper
• Prenatal and neonatal drug metabolism in man

  1980cited by this paper
• Association of diethylstilbestrol exposure in utero with cryptorchidism, testicular hypoplasia and semen abnormalities.

  1979cited by this paper
• Biochemical and histological studies on prostates in castrated dogs after treatment with androstanediol, oestradiol and cyproterone acetate.

  1979cited by this paper
• Metabolic activation/deactivation reactions during perinatal development.

  1979cited by this paper
• Journal Abstracts

  1978cited by this paper
• Pathological semen and anatomical abnormalities of the genital tract in human male subjects exposed to diethylstilbestrol in utero.

  1977cited by this paper
• Follow‐up Study of Male and Female Offspring of DES‐Exposed Mothers

  1977cited by this paper
• Perinatal development of conjugative enzyme systems.

  1976cited by this paper
• Dose-dependent kinetics of diethylstilbestrol in the rat.

  1976cited by this paper
• Reproductive tract lesions in male mice exposed prenatally to diethylstilbestrol

  1975cited by this paper
• Adenocarcinoma of the vagina. Association of maternal stilbestrol therapy with tumor appearance in young women.

  1971cited by this paper
• The histology of the human foetal and prepubertal prostates.

  1951influential reference
• Synthetic Œstrogenic Agents without the Phenanthrene Nucleus

  1936cited by this paper

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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2018cites this paper
• Melatonin ameliorates bisphenol A-induced perturbations of the prostate gland of adult Wistar rats.

  2018cites this paper
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  2018cites this paper
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  2017cites this paper
• Derivation of an oral Maximum Allowable Dose Level for Bisphenol A

  2017cites this paper
• Methods for studying human organogenesis.

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  2016cites this paper
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• Triclosan exacerbates the presence of 14C-bisphenol A in tissues of female and male mice.

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• Effect of prenatal exposure to bisphenol a on the vagina of albino rats: immunohistochemical and ultrastructural study.

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