The PEBP2betaMYH11 fusion created by Inv(16)(p13;q22) in myeloid leukemia impairs neutrophil maturation and contributes to granulocytic dysplasia.

No abstract is available for this paper.

• Publication year

  1998

• Venue

  Proceedings of the National Academy of Sciences of the United States of America

• Publication date

  1998-09-29

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1073/PNAS.95.20.11863PMID 9751756PMCID PMC21731
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Expression of a knocked-in AML1-ETO leukemia gene inhibits the establishment of normal definitive hematopoiesis and directly generates dysplastic hematopoietic progenitors.

  1998cited by this paper
• Cytoplasmic Sequestration of the Polyomavirus Enhancer Binding Protein 2 (PEBP2)/Core Binding Factor α (CBFα) Subunit by the Leukemia-Related PEBP2/CBFβ-SMMHC Fusion Protein Inhibits PEBP2/CBF-Mediated Transactivation

  1998cited by this paper
• Cytoplasmic sequestration of the polyomavirus enhancer binding protein 2 (PEBP2)/core binding factor alpha (CBFalpha) subunit by the leukemia-related PEBP2/CBFbeta-SMMHC fusion protein inhibits PEBP2/CBF-mediated transactivation.

  1998cited by this paper
• Hematopoiesis in the fetal liver is impaired by targeted mutagenesis of a gene encoding a non-DNA binding subunit of the transcription factor, polyomavirus enhancer binding protein 2/core binding factor.

  1997cited by this paper
• Characterization of the bovine C alpha gene.

  1997cited by this paper
• A PMLRARalpha transgene initiates murine acute promyelocytic leukemia.

  1997cited by this paper
• CBFβ-SMMHC, expressed in M4Eo AML, reduced CBF DNA-binding and inhibited the G1 to S cell cycle transition at the restriction point in myeloid and lymphoid cells

  1997cited by this paper
• Oncogenes as Transcriptional Regulators

  1997cited by this paper
• Frequency of CBF beta/MYH11 fusion transcripts in patients entered into the U.K. MRC AML trials. The MRC Adult Leukaemia Working Party.

  1997cited by this paper
• A PMLRARα transgene initiates murine acute promyelocytic leukemia

  1997cited by this paper
• Frequency of CBFβ/MYH11 fusion transcripts in patients entered into the U.K. MRC AML trials

  1997cited by this paper
• AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis.

  1996cited by this paper
• Failure of embryonic hematopoiesis and lethal hemorrhages in mouse embryos heterozygous for a knocked-in leukemia gene CBFB-MYH11.

  1996cited by this paper
• Identification of the chimeric protein product of the CBFB‐MYH11 fusion gene in inv(16) leukemia cells

  1996cited by this paper
• Regulation of immature myeloid cell differentiation by PEBP2/CBF, Myb, C/EBP and Ets family members.

  1996cited by this paper
• Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis.

  1996cited by this paper
• The CBFb subunit is essential for CBFa2 (AML1)function in vivo

  1996cited by this paper
• The CBFbeta subunit is essential for CBFalpha2 (AML1) function in vivo.

  1996cited by this paper
• Identification of the chimeric protein product of the CBFB-MYH11 fusion gene in inv(16) leukemia cells.

  1996cited by this paper
• t(8;21) myelodysplasia, an early presentation of M2 AML

  1995cited by this paper
• Subcellular localization of the alpha and beta subunits of the acute myeloid leukemia-linked transcription factor PEBP2/CBF

  1995cited by this paper
• Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia.

  1995cited by this paper
• Myristoylation and differential palmitoylation of the HCK protein-tyrosine kinases govern their attachment to membranes and association with caveolae

  1995cited by this paper
• High frequency of t(12;21) in childhood B-lineage acute lymphoblastic leukemia.

  1995cited by this paper
• A new transcription factor family associated with human leukemias.

  1995cited by this paper
• Correlation of cytogenetic results with immunophenotype, genotype, clinical features, and ras mutation in acute myeloid leukemia. A study of 235 Chinese patients in Taiwan.

  1995cited by this paper
• Generation of the AML1‐EVI‐1 fusion gene in the t(3;21)(q26;q22) causes blastic crisis in chronic myelocytic leukemia.

  1994cited by this paper
• PEBP2/CBF, the murine homolog of the human myeloid AML1 and PEBP2 beta/CBF beta proto-oncoproteins, regulates the murine myeloperoxidase and neutrophil elastase genes in immature myeloid cells

  1994cited by this paper
• bcl-2 inhibits apoptosis of neutrophils but not their engulfment by macrophages

  1994cited by this paper
• The balanced and the unbalanced chromosome aberrations of acute myeloid leukemia may develop in different ways and may contribute differently to malignant transformation.

  1994cited by this paper
• Acute myeloid leukemia with Inv (16) produces a chimeric transcription factor with a myosin heavy chain tail.

  1994cited by this paper
• The 3;21 translocation in myelodysplasia results in a fusion transcript between the AML1 gene and the gene for EAP, a highly conserved protein associated with the Epstein-Barr virus small RNA EBER 1.

  1993cited by this paper
• Fusion between transcription factor CBF beta/PEBP2 beta and a myosin heavy chain in acute myeloid leukemia.

  1993cited by this paper
• Production of high-titer helper-free retroviruses by transient transfection.

  1993cited by this paper
• Mouse MRP8 and MRP14, two intracellular calcium-binding proteins associated with the development of the myeloid lineage.

  1992cited by this paper
• Transplantable myeloproliferative disease induced in mice by an interleukin 6 retrovirus

  1992cited by this paper
• AML-associated cytogenetic abnormalities (inv (16), del (16), t(8;21)) in patients with myelodysplastic syndromes.

  1992cited by this paper
• t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1.

  1991cited by this paper
• FVB/N: an inbred mouse strain preferable for transgenic analyses.

  1991cited by this paper
• The role of ras gene mutations in myeloproliferative disorders.

  1990cited by this paper
• The role of ras gene mutations in myeloproliferative disorders.

  1990cited by this paper
• Myelodysplastic syndrome preceding acute myelomonocytic leukemia with dysplastic marrow eosinophilia and inv(16).

  1989cited by this paper
• A myelodysplastic syndrome with marrow eosinophilia terminating in acute nonlymphocytic leukemia, associated with an abnormal chromosome 16.

  1987cited by this paper
• The c-myc oncogene perturbs B lymphocyte development in E-mu-myc transgenic mice.

  1986cited by this paper
• Neutrophil activity in abscess-bearing mice: comparative studies with neutrophils isolated from peripheral blood, elicited peritoneal exudates, and abscesses

  1986cited by this paper
• Association of an inversion of chromosome 16 with abnormal marrow eosinophils in acute myelomonocytic leukemia. A unique cytogenetic-clinicopathological association.

  1983cited by this paper
• An Atlas of Laboratory Animal Haematology

  1982cited by this paper

• JAK2 inhibition mediates clonal selection of RAS pathway mutations in myeloproliferative neoplasms

  2025cites this paper
• Mouse Models of Frequently Mutated Genes in Acute Myeloid Leukemia

  2021cites this paper
• Overview of KRAS‐Driven Genetically Engineered Mouse Models of Non‐Small Cell Lung Cancer

  2015influential citation
• Akute myeloische Leukämie

  2015cites this paper
• Mouse models for core binding factor leukemia

  2015cites this paper
• Study of acute myeloid leukaemia with known chromosomal translocations A Thesis Submitted for the Degree of Doctor of Philosophy

  2014cites this paper
• Localization of the NRAS:BCL-2 complex determines anti-apoptotic features associated with progressive disease in myelodysplastic syndromes.

  2013cites this paper
• Engineering mouse models with myelodysplastic syndrome human candidate genes; how relevant are they?

  2013cites this paper
• Niclas mouse model of AML by targeting primitive LSK and progenitor cells BCL-2 inhibition with ABT-737 prolongs survival in an NRAS / BCL-2

  2013cites this paper
• BCL-2 inhibition with ABT-737 prolongs survival in an NRAS/BCL-2 mouse model of AML by targeting primitive LSK and progenitor cells.

  2013cites this paper
• Leukemias, Lymphomas, and Other Related Disorders

  2013cites this paper
• human CD34+ cells activity alters gene expression and differentiation of α Induction of C/EBP

  2013cites this paper
• Characterization of the putative CALM/AF10 collaborator Meis1 in leukemia development

  2013cites this paper
• diseases in mice Oncogenic NRAS rapidly and efficiently induces CMML- and AML-like

  2013cites this paper
• Hematopoiesis and leukemogenesis in mice expressing oncogenic NrasG12D from the endogenous locus.

  2011cites this paper
• Cooperating Events in Core Binding Factor Leukemia Development: A Dissertation

  2011cites this paper
• Nuevas estrategias terapéuticas en leucemias agudas mieloblásticas: evaluación preclínica de la eficacia y el mecanismo de ación

  2011cites this paper
• Endogenous oncogenic Nras mutation promotes aberrant GM-CSF signaling in granulocytic/monocytic precursors in a murine model of chronic myelomonocytic leukemia.

  2010cites this paper
• Molecular diagnostics of acute myeloid leukaemia

  2009cites this paper
• RAS oncogene suppression induces apoptosis followed by more differentiated and less myelosuppressive disease upon relapse of acute myeloid leukemia

  2009cites this paper
• RAS oncogene suppression induces apoptosis followed by more differentiated and less myelosuppressive disease upon relapse of acute myeloid leukemia.

  2009cites this paper
• Analysis of senescence-like growth arrest induced by RUNX1 and its fusion derived oncoproteins

  2008cites this paper
• Src family kinases and the MEK/ERK pathway in the regulation of myeloid differentiation and myeloid leukemogenesis.

  2008cites this paper
• FLT 3-ITD cooperates with inv ( 16 ) to promote progression to acute myeloid leukemia

  2008cites this paper
• Mouse model for NRAS-induced leukemogenesis.

  2008cites this paper
• FLT3-ITD cooperates with inv(16) to promote progression to acute myeloid leukemia.

  2008cites this paper
• Complementing mutations in core binding factor leukemias: from mouse models to clinical applications

  2008influential citation
• Detection of the CBFB/MYH11 fusion gene in de novo acute myeloid leukemia (AML): a single-institution study of 224 Japanese AML patients.

  2007cites this paper
• Inhibition of Src family kinases enhances retinoic acid–induced gene expression and myeloid differentiation

  2007cites this paper
• Reactive oxygen species, DNA damage, and error-prone repair: a model for genomic instability with progression in myeloid leukemia?

  2007cites this paper
• Deregulation of apoptosis in acute myeloid leukemia.

  2007cites this paper
• Oncogenic NRAS, KRAS, and HRAS exhibit different leukemogenic potentials in mice.

  2007influential citation
• BCL-2 and mutant NRAS interact physically and functionally in a mouse model of progressive myelodysplasia.

  2007influential citation
• Myeloid Leukemia? Repair: A Model for Genomic Instability with Progression in Reactive Oxygen Species, DNA Damage, and Error-Prone

  2007cites this paper
• T-lymphoid, megakaryocyte, and granulocyte development are sensitive to decreases in CBFbeta dosage.

  2007cites this paper
• Oncogenic NRAS rapidly and efficiently induces CMML- and AML-like diseases in mice.

  2006cites this paper
• Fusion oncogenes in tumor development.

  2005cites this paper
• Fusion oncogenes.

  2005cites this paper
• Pathogenesis of acute myeloid leukaemia and inv(16)(p13;q22): a paradigm for understanding leukaemogenesis?

  2005cites this paper
• The inv(16) Cooperates with ARF Haploinsufficiency to Induce Acute Myeloid Leukemia*

  2005cites this paper
• Mechanism of leukemogenesis by the inv(16) chimeric gene CBFB/PEBP2B-MHY11

  2004cites this paper
• Targeted therapies in myeloid leukemia.

  2004cites this paper
• Expression of Human CXCR2 in Murine Neutrophils as a Model for Assessing Cytomegalovirus Chemokine vCXCL-1 Function In Vivo

  2004cites this paper
• Second hit mutations in the RTK/RAS signaling pathway in acute myeloid leukemia with inv(16).

  2004cites this paper
• RAS mutations are frequent events in AML, with their report- ed frequency being up to 30%.

  2004cites this paper
• The Runx genes: lineage-specific oncogenes and tumor suppressors

  2004cites this paper
• Dysplasia and high proliferation rate are common in acute myeloid leukemia with inv(16)(p13q22).

  2003cites this paper
• Cooperation of Cytokine Signaling with Chimeric Transcription Factors in Leukemogenesis: PML-Retinoic Acid Receptor Alpha Blocks Growth Factor-Mediated Differentiation

  2003cites this paper
• Structural and functional characterization of Runx1, CBFβ, and CBFβ-SMMHC

  2003cites this paper
• Induction of C/EBPalpha activity alters gene expression and differentiation of human CD34+ cells.

  2003cites this paper
• Structural and functional characterization of Runx1, CBF beta, and CBF beta-SMMHC.

  2003cites this paper
• The role of a Runt domain transcription factor AML1/RUNX1 in leukemogenesis and its clinical implications.

  2003cites this paper
• Altered affinity of CBF beta-SMMHC for Runx1 explains its role in leukemogenesis.

  2002cites this paper
• Altered affinity of CBFβ-SMMHC for Runx1 explains its role in leukemogenesis

  2002cites this paper
• Genetic pathways in therapy-related myelodysplasia and acute myeloid leukemia.

  2002cites this paper
• Transcription factor fusions in acute leukemia: variations on a theme

  2002cites this paper
• The clinical significance of cytogenetic abnormalities in acute myeloid leukaemia.

  2001cites this paper
• Bcl-2 Cooperates with Promyelocytic Leukemia Retinoic Acid Receptor α Chimeric Protein (Pmlrarα) to Block Neutrophil Differentiation and Initiate Acute Leukemia

  2001cites this paper
• AML1-ETO expression is directly involved in the development of acute myeloid leukemia in the presence of additional mutations

  2001cites this paper
• Detection and quantification of CBFB/MYH11 fusion transcripts in patients with inv(16)‐positive acute myeloblastic leukemia by real‐time RT‐PCR

  2001cites this paper
• Function of the inv(16) fusion gene CBFB-MYH11.

  2001cites this paper
• Molecular, cytogenetic and genetic abnormalities in MDS and secondary AML.

  2001cites this paper
• Rapid mutational analysis of N-ras proto-oncogene in hematologic malignancies: study of 77 Greek patient.

  2001cites this paper
• Core-binding factor beta (CBFbeta), but not CBFbeta-smooth muscle myosin heavy chain, rescues definitive hematopoiesis in CBFbeta-deficient embryonic stem cells.

  2001cites this paper
• The expression of ETV6/CBFA2 (TEL/AML1) is not sufficient for the transformation of hematopoietic cell lines in vitro or the induction of hematologic disease in vivo.

  2001cites this paper
• Common themes in the pathogenesis of acute myeloid leukemia

  2001cites this paper
• Function of the inv(16) fusion gene CBFB-MYH11

  2001cites this paper
• Core-binding factor b (CBF b ), but not CBF b –smooth muscle myosin heavy chain, rescues definitive hematopoiesis in CBF b -deficient embryonic stem cells

  2001cites this paper
• Role of the transcription factor AML-1 in acute leukemia and hematopoietic differentiation.

  2000cites this paper
• H RAS mutations in haematologically normal individuals.

  2000cites this paper
• Leukemia initiated by PMLRARalpha: the PML domain plays a critical role while retinoic acid-mediated transactivation is dispensable.

  2000cites this paper
• 自家骨髄移植術を用いて治療したinv (16) (p13;q22) 急性骨髄性白血病 (FABM4E) の1例

  2000cites this paper
• Human AML1/MDS1/EVI1 fusion protein induces an acute myelogenous leukemia (AML) in mice: a model for human AML.

  2000cites this paper
• The PEBP2β/CBFβ-SMMHC chimeric protein is localized both in the cell membrane and nuclear subfractions of leukemic cells carrying chromosomal inversion 16

  2000cites this paper
• A full-length Cbfa1 gene product perturbs T-cell development and promotes lymphomagenesis in synergy with MYC

  1999influential citation
• Leukemogenesis by CBF oncoproteins

  1999cites this paper
• Lymphoid development from stem cells and the common lymphocyte progenitors.

  1999cites this paper
• Mammalian runt‐domain proteins and their roles in hematopoiesis, osteogenesis, and leukemia

  1999cites this paper
• Regulation mechanisms for the heterodimeric transcription factor, PEBP2/CBF.

  1999cites this paper