Expression analysis of MiR-21, MiR-205, and MiR-342 in breast cancer in Iran.

MicroRNAs (miRNAs) are short non-coding RNA molecules characterized by their regulatory roles in cancer and gene expression. We analyzed the expression of miR-21, miR-205, and miR-342 in 59 patients with breast cancer. Samples were divided into three different groups according to their immunohistochemistry (IHC) classification: ER-positive and/or PR-positive group (ER+ and/or PR+; group I); HER2-positive group (HER2+; group II); and ER/PR/HER2- negative (ER-/PR-/HER2-; group III) as the triple negative group. The expression levels of the 3 miRNAs were analyzed in the tumor samples and the compared with the normal neighboring dissected tumor (NNDT) samples in all three groups. The expression of miR-21 was similar in all three groups. In patients positive for P53 by IHC, positive for axillary lymph node metastasis and higher tumor stages, it appeared to have significantly elevated. However, significant increase was not found among the 18 fibroadenoma samples. Both miR-205 and miR-342 expressions were significantly down regulated in group III. We conclude that miR-21 does not discriminate between different breast cancer groups. In contrast, miR-205 and miR-342 may be used as potential biomarkers for diagnosis of triple negative breast cancer.

• Publication year

  2012

• Venue

  Asian Pacific Journal of Cancer Prevention

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.7314/APJCP.2012.13.3.873PMID 22631664
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Clinical implications for BRCA gene mutation in breast cancer

  2012cited by this paper
• Tumor suppressor p16INK4a controls oncogenic K‐Ras function in human pancreatic cancer cells

  2012cited by this paper
• Functional Inactivation of Endogenous MDM2 and CHIP by HSP90 Causes Aberrant Stabilization of Mutant p53 in Human Cancer Cells

  2011cited by this paper
• High expression of miR‐21 in tumor stroma correlates with increased cancer cell proliferation in human breast cancer

  2011cited by this paper
• MicroRNA expression analysis in triple-negative (ER, PR and Her2/neu) breast cancer

  2011cited by this paper
• Her2 amplification status in Iranian breast cancer patients: comparison of immunohistochemistry (IHC) and fluorescence in situ hybridisation (FISH).

  2011cited by this paper
• ErbB2 down-regulates microRNA-205 in breast cancer.

  2011cited by this paper
• Comorbidities in the aging breast cancer population: are current assessments leading to improved outcomes?

  2011cited by this paper
• MicroRNA signatures predict oestrogen receptor, progesterone receptor and HER2/neu receptor status in breast cancer

  2009cited by this paper
• Clinical significance of miR-21 expression in breast cancer: SYBR-Green I-based real-time RT-PCR study of invasive ductal carcinoma.

  2009cited by this paper
• Expression of miR-21 and its targets (PTEN, PDCD4, TM1) in flat epithelial atypia of the breast in relation to ductal carcinoma in situ and invasive carcinoma

  2009cited by this paper
• Is it safe practice not to biopsy fibroadenomas in women under 30?

  2009cited by this paper
• Amplification efficiency: linking baseline and bias in the analysis of quantitative PCR data

  2009influential reference
• MicroRNA-21 targets a network of key tumor-suppressive pathways in glioblastoma cells.

  2008cited by this paper
• MicroRNA expression profiling of human breast cancer identifies new markers of tumor subtype

  2007cited by this paper
• A rational route to probing membrane proteins

  2007cited by this paper
• MicroRNA expression profiling of single whole embryonic stem cells

  2006cited by this paper
• Post-transcriptional regulation of microRNA expression.

  2006cited by this paper
• Optimized high-throughput microRNA expression profiling provides novel biomarker assessment of clinical prostate and breast cancer biopsies

  2006cited by this paper
• MicroRNA gene expression deregulation in human breast cancer.

  2005cited by this paper
• Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets.

  2005cited by this paper
• MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells.

  2005cited by this paper
• Assumption-free analysis of quantitative real-time polymerase chain reaction (PCR) data.

  2003influential reference
• Trastuzumab, an appropriate first-line single-agent therapy for HER2-overexpressing metastatic breast cancer

  2003cited by this paper
• MicroRNA pathways in flies and worms: growth, death, fat, stress, and timing.

  2003cited by this paper
• Evaluation of HER-2/neu immunohistochemical assay sensitivity and scoring on formalin-fixed and paraffin-processed cell lines and breast tumors: a comparative study involving results from laboratories in 21 countries.

  2002cited by this paper
• Relative expression software tool (REST©) for group-wise comparison and statistical analysis of relative expression results in real-time PCR

  2002cited by this paper
• DNA mismatch repair defects: role in colorectal carcinogenesis.

  2002cited by this paper
• The p53 pathway in breast cancer

  2002cited by this paper
• [The female breast].

  1993cited by this paper
• Clonal analysis of fibroadenoma and phyllodes tumor of the breast.

  1993cited by this paper
• Chlamydia

  1990cited by this paper
• Pathologic basis of disease

  1974cited by this paper

• Therapeutic Potential of MicroRNAs in Targeting Breast Cancer Stem Cells: A Systematic Review.

  2026cites this paper
• Text Mining Strategy Identifies Gene Networks Under Control of miR‐21 in Breast Cancer Development

  2025cites this paper
• Evaluating MicroRNAs as Diagnostic Tools for Lymph Node Metastasis in Breast Cancer: Findings from a Systematic Review and Meta-Analysis.

  2024cites this paper
• miRNAs in the prognosis of triple-negative breast cancer: A review.

  2023cites this paper
• Role of microRNAs in tumor progression among Iranian population: An overview

  2022cites this paper
• Alteration in the expression of microRNA-21 regulated target genes: Role in breast cancer

  2022cites this paper
• Highly sensitive and reliable detection of microRNA for clinically disease surveillance using SERS biosensor integrated with catalytic hairpin assembly amplification technology.

  2022cites this paper
• The Application of Bi-clustering and Bayesian Network for Gene Sets Network Construction in Breast Cancer Microarray Data

  2022cites this paper
• Passive Microwave Radiometry and microRNA Detection for Breast Cancer Diagnostics

  2022cites this paper
• Evaluation of miRNAs 9 and 342 expressions in sera as diagnostic and prognostic biomarkers for breast cancer

  2021cites this paper
• Molecular studies of breast cancer in Iran: A Systematic Review

  2020cites this paper
• BCTT_A_269519 141..151

  2020cites this paper
• miRNAs and Its Regulatory Role on Autophagy in Tumor Microenvironment

  2020cites this paper
• Mirna21 Expression in the Breast Cancer Tumor Tissue is Independent of Neoadjuvant Chemotherapy

  2020cites this paper
• miRNA Expression Profiles in Luminal A Breast Cancer—Implications in Biology, Prognosis, and Prediction of Response to Hormonal Treatment

  2020cites this paper
• MiR-194 promotes hepatocellular carcinoma through negative regulation of CADM1.

  2020cites this paper
• MicroRNA-based potential diagnostic, prognostic and therapeutic applications in triple-negative breast cancer

  2019cites this paper
• Upregulation of AKT1 and downregulation of AKT3 caused by dysregulation of microRNAs contributes to pathogenesis of hemangioma by promoting proliferation of endothelial cells

  2019cites this paper
• Genetic and molecular biology of breast cancer among Iranian patients

  2019cites this paper
• MicroRNAs Involved in Carcinogenesis, Prognosis, Therapeutic Resistance, and Applications in Human Triple-Negative Breast Cancer

  2019cites this paper
• Aberrant expression of a five‐microRNA signature in breast carcinoma as a promising biomarker for diagnosis

  2019cites this paper
• Histological detection and prognostic value of regulators of metaphase-anaphase transition in breast cancer

  2018influential citation
• MicroRNA-342 inhibits cell proliferation and invasion in nasopharyngeal carcinoma by directly targeting ZEB1.

  2018cites this paper
• Association of rs1042522 SNP with Clinicopathologic Factors of Breast Cancer Patients in the Markazi Province of Iran

  2018cites this paper
• Integrin α5 down-regulation by miR-205 suppresses triple negative breast cancer stemness and metastasis by inhibiting the Src/Vav2/Rac1 pathway.

  2018cites this paper
• Regulation of epithelial to mesenchymal transition by BRCA1 in breast cancer.

  2018cites this paper
• Mi R - 520 d expression analysis in breast cancer

  2018cites this paper
• Análise do perfil de expressão global de miRNA em carcinomas mamários e linfonodos metastáticos de cadelas

  2018cites this paper
• Autophagy-Regulating microRNAs and Cancer

  2017cites this paper
• Cancer Genetics at a Glance: The Comprehensive Insights

  2017cites this paper
• Deregulation of miR-126-3p in basal-like breast cancers stroma and its clinical significance.

  2017cites this paper
• A novel panel of serum miR-21/miR-155/miR-365 as a potential diagnostic biomarker for breast cancer

  2017cites this paper
• THE ROLE OF THE CLINICAL AND MOLECULAR ASSAYS IN PROSTATE CANCER DETECTION

  2017cites this paper
• MicroRNA-342 inhibits the progression of glioma by directly targeting PAK4.

  2017cites this paper
• miR-21, An Oncogenic Target miRNA for Cancer Therapy: Molecular Mechanisms and Recent Advancements in Chemo and Radio-resistance.

  2017cites this paper
• MicroRNA expression profiling identifies decreased expression of miR-205 in inflammatory breast cancer

  2016cites this paper
• Sensitive electrochemical determination of miRNAs based on a sandwich assay onto magnetic microcarriers and hybridization chain reaction amplification.

  2016influential citation
• Tumor suppressor microRNAs: Targeted molecules and signaling pathways in breast cancer.

  2016cites this paper
• EC GYNAECOLOGY Mini Review MicroRNAs and Their Clinical Importance in Triple Negative Breast Cancer

  2016cites this paper
• Deregulated miRNAs in Triple Negative Breast Cancer

  2016cites this paper
• Combined Label-Free Quantitative Proteomics and microRNA Expression Analysis of Breast Cancer Unravel Molecular Differences with Clinical Implications.

  2015cites this paper
• Extracellular Nucleic Acids and Cancer

  2015cites this paper
• MicroRNAs-mediated cell fate in triple negative breast cancers.

  2015cites this paper
• EVALUATION OF MICRORNA-21 IN INVASIVE DUCTAL CARCINOMA IN COMPARISON TO CLINICOPATHOLOGICAL STATUS BY STEM-LOOP RT-PCR PROCEDURE

  2015cites this paper
• The expression and clinical significance of serum miR-205 for breast cancer and its role in detection of human cancers.

  2015cites this paper
• Simultaneous detection of two breast cancer-related miRNAs in tumor tissues using p19-based disposable amperometric magnetobiosensing platforms.

  2015influential citation
• miR-205 regulates A549 cells proliferation by targeting PTEN.

  2015cites this paper
• Expression of miR-520 d in breast cancer

  2015cites this paper
• MicroRNA-21 in breast cancer: diagnostic and prognostic potential

  2014cites this paper
• The important roles of miR-205 in normal physiology, cancers and as a potential therapeutic target.

  2014cites this paper
• Diagnostic and prognostic value of miR-205 in colorectal cancer.

  2014cites this paper
• microRNA alterations in ALDH positive mammary epithelial cells: a crucial contributing factor towards breast cancer risk reduction in case of early pregnancy

  2014cites this paper
• Pathogenesis of Breast Cancer Metastasis to Brain: a Comprehensive Approach to the Signaling Network

  2014cites this paper
• miR-205 and miR-200c: Predictive Micro RNAs for Lymph Node Metastasis in Triple Negative Breast Cancer

  2014cites this paper
• Direct Determination of miR‐21 in Total RNA Extracted from Breast Cancer Samples Using Magnetosensing Platforms and the p19 Viral Protein as Detector Bioreceptor

  2014cites this paper
• Insights into the diverse roles of miR-205 in human cancers.

  2014cites this paper
• The Role of miRNAs Playing in Human Cancers Chemosensitivity

  2014cites this paper
• miR-342 Regulates BRCA1 Expression through Modulation of ID4 in Breast Cancer

  2014cites this paper
• RNAs in Mature Spermatozoa

  2013cites this paper
• The role of p19 C-H-Ras protein in metastasis and proliferative pathways

  2013cites this paper
• Neoplasia from genetic point of view.

  2013cites this paper
• Tumor Suppressive Function of mir-205 in Breast Cancer Is Linked to HMGB3 Regulation

  2013cites this paper
• Role of MYH polymorphisms in sporadic colorectal cancer in China: a case-control, population-based study.

  2013cites this paper
• Identification of microRNA-205 as a potential prognostic indicator for human glioma.

  2013cites this paper
• MicroRNAs and Triple Negative Breast Cancer

  2013cites this paper
• Serum BMP-2 up-regulation as an indicator of poor survival in advanced non-small cell lung cancer patients.

  2013cites this paper
• Epithelial mesenchymal transition from a natural gestational orchestration to a bizarre cancer disturbance

  2013cites this paper
• Pemetrexed as a component of first-, second- and third- line chemotherapy in treating patients with metastatic lung adenocarcinoma.

  2013cites this paper
• MiR-205 in cancer: an angel or a devil?

  2013cites this paper
• MiR-520d expression analysis in breast cancer

  2013cites this paper