IgA nephropathy enigma.

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Clinical Immunology

• Publication date

  2016-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.clim.2016.07.011PMID 27444044PMCID PMC5159197
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• IgA nephropathy.

  2020cited by this paper
• IgA nephropathy

  2016cited by this paper
• IgA1 Protease Treatment Reverses Mesangial Deposits and Hematuria in a Model of IgA Nephropathy.

  2016cited by this paper
• The Origin and Activities of IgA1-Containing Immune Complexes in IgA Nephropathy

  2016influential reference
• Recurrent IgA nephropathy is predicted by altered glycosylated IgA, autoantibodies and soluble CD89 complexes.

  2015cited by this paper
• Microbial Evasion of IgA Functions

  2015influential reference
• Immunoglobulin Transport and Immunoglobulin Receptors

  2015cited by this paper
• Phylogeny and Comparative Physiology of Mucosal Immunoglobulins

  2015cited by this paper
• N-acetylgalactosaminide α2,6-sialyltransferase II is a candidate enzyme for sialylation of galactose-deficient IgA1, the key autoantigen in IgA nephropathy.

  2015cited by this paper
• Nanobody-based products as research and diagnostic tools.

  2014cited by this paper
• The genetics and immunobiology of IgA nephropathy.

  2014cited by this paper
• Discovery of new risk loci for IgA nephropathy implicates genes involved in immunity against intestinal pathogens

  2014cited by this paper
• IgA nephropathy: molecular mechanisms of the disease.

  2013influential reference
• Pathogenesis of immunoglobulin A nephropathy: recent insight from genetic studies.

  2013cited by this paper
• Cytokines Alter IgA1 O-Glycosylation by Dysregulating C1GalT1 and ST6GalNAc-II Enzymes

  2013influential reference
• Introduction to heavy chain antibodies and derived Nanobodies.

  2012cited by this paper
• Aberrant O-glycosylation and anti-glycan antibodies in an autoimmune disease IgA nephropathy and breast adenocarcinoma

  2012cited by this paper
• Spleen Tyrosine Kinase Is Important in the Production of Proinflammatory Cytokines and Cell Proliferation in Human Mesangial Cells following Stimulation with IgA1 Isolated from IgA Nephropathy Patients

  2012cited by this paper
• The IgA1 immune complex-mediated activation of the MAPK/ERK kinase pathway in mesangial cells is associated with glomerular damage in IgA nephropathy.

  2012cited by this paper
• Glycosylation of IgA1 and pathogenesis of IgA nephropathy

  2012cited by this paper
• Geographic Differences in Genetic Susceptibility to IgA Nephropathy: GWAS Replication Study and Geospatial Risk Analysis

  2012cited by this paper
• The level of galactose-deficient IgA1 in the sera of patients with IgA nephropathy is associated with disease progression

  2012cited by this paper
• Autoantibodies targeting galactose-deficient IgA1 associate with progression of IgA nephropathy.

  2012cited by this paper
• The pathophysiology of IgA nephropathy.

  2011influential reference
• IgA1 immune complexes from pediatric patients with IgA nephropathy activate cultured human mesangial cells.

  2011cited by this paper
• Clustered O-Glycans of IgA1

  2010cited by this paper
• Single domain antibodies: promising experimental and therapeutic tools in infection and immunity

  2009cited by this paper
• Aberrantly glycosylated IgA1 in IgA nephropathy patients is recognized by IgG antibodies with restricted heterogeneity.

  2009influential reference
• Microbial IgA protease removes IgA immune complexes from mouse glomeruli in vivo: potential therapy for IgA nephropathy.

  2008cited by this paper
• IgA1-secreting cell lines from patients with IgA nephropathy produce aberrantly glycosylated IgA1.

  2008cited by this paper
• IgA glycosylation and IgA immune complexes in the pathogenesis of IgA nephropathy.

  2008cited by this paper
• Bacterial protease for the treatment of IgA nephropathy.

  2008cited by this paper
• IgA nephropathy: current views of immune complex formation.

  2007cited by this paper
• Identification and characterization of CMP-NeuAc:GalNAc-IgA1 alpha2,6-sialyltransferase in IgA1-producing cells.

  2007cited by this paper
• IgA nephropathy and Henoch-Schoenlein purpura nephritis: aberrant glycosylation of IgA1, formation of IgA1-containing immune complexes, and activation of mesangial cells.

  2007cited by this paper
• Association of single-nucleotide polymorphisms in the polymeric immunoglobulin receptor gene with immunoglobulin A nephropathy (IgAN) in Japanese patients

  2003cited by this paper
• Initiation of O-Glycan Synthesis in IgA1 Hinge Region Is Determined by a Single Enzyme, UDP-N-Acetyl-α-d-galactosamine:PolypeptideN-Acetylgalactosaminyltransferase 2*

  2003cited by this paper
• Initiation of O-glycan synthesis in IgA1 hinge region is determined by a single enzyme, UDP-N-acetyl-α-D-galactosamine : Polypeptide N-acetylgalactosaminyltransferase 2

  2003cited by this paper
• Progress in Molecular and Genetic Studies of IgA Nephropathy

  2001cited by this paper
• Heterogeneity of O-glycosylation in the hinge region of human IgA1.

  2000cited by this paper
• Intercapillary deposits of IgA-IgC.

  2000cited by this paper
• Circulating immune complexes in IgA nephropathy consist of IgA1 with galactose-deficient hinge region and antiglycan antibodies.

  1999influential reference
• [Tn syndrome].

  1998cited by this paper
• Origin and structure of pathogenic IgA in IgA nephropathy.

  1997cited by this paper
• Structural and antigenic types of cell wall polysaccharides from viridans group streptococci with receptors for oral actinomyces and streptococcal lectins

  1997cited by this paper
• Galactose-deficient IgA1 in sera of IgA nephropathy patients is present in complexes with IgG.

  1997cited by this paper
• Structural heterogeneity of glycans in IgA molecules: Implications for IgA nephropathy

  1997cited by this paper
• Immunoreactive T and Tn epitopes in cancer diagnosis, prognosis, and immunotherapy

  1997cited by this paper
• Biological significance of IgA1 proteases in bacterial colonization and pathogenesis: critical evaluation of experimental evidence *

  1996cited by this paper
• Increased dimeric IgA producing B cells in the bone marrow in IgA nephropathy determined by in situ hybridisation for J chain mRNA.

  1996cited by this paper
• Epstein-Barr virus and its replication

  1996cited by this paper
• Galactosylation of N‐ and O‐linked carbohydrate moieties of IgA1 and IgG in IgA nephropathy

  1995cited by this paper
• Titration of inhibiting antibodies to bacterial IgA1 proteases in human sera and secretions.

  1995cited by this paper
• Changes in circulating immune complex and charge distribution with upper respiratory tract inflammation in IgA nephropathy.

  1995cited by this paper
• Increased immunoglobulin A and immunoglobulin A1 cells in bone marrow trephine biopsy specimens in immunoglobulin A nephropathy.

  1994cited by this paper
• Animal models as a means to study IgA nephropathy.

  1993cited by this paper
• The pathogenic role of immunoglobulin A polymers in immunoglobulin A nephropathy.

  1993cited by this paper
• Evolutionary hypervariability in the hinge region of the immunoglobulin alpha gene.

  1990cited by this paper
• Mucosal immunology.

  1990influential reference
• Structure and cell surface maturation of the attachment glycoprotein of human respiratory syncytial virus in a cell line deficient in O glycosylation

  1989cited by this paper
• The bone marrow as production site of the IgA deposited in the kidneys of patients with IgA nephropathy.

  1988cited by this paper
• Antibodies directed at Fab of IgA in the sera of normal individuals and IgA nephropathy patients.

  1987cited by this paper
• The common mucosal immune system and current strategies for induction of immune responses in external secretions

  1987cited by this paper
• Normal human sera contain antibodies directed at Fab of IgA.

  1987cited by this paper
• Aberrant synthesis of antibodies directed at the Fab fragment of IgA in patients with IgA nephropathies.

  1987cited by this paper
• Anaphylactic reactions after gamma globulin administration in patients with hypogammaglobulinemia. Detection of IgE antibodies to IgA.

  1986cited by this paper
• IgG anti-IgA1 and anti-IgA2 antibodies: their measurement by an enzyme-linked immunosorbent assay and their relationship to disease.

  1986cited by this paper
• [IgA nephropathy].

  1985influential reference
• In vitro regulation of IgA subclass synthesis. II. The source of IgA2 plasma cells.

  1984cited by this paper
• O-linked oligosaccharides are acquired by herpes simplex virus glycoproteins in the Golgi apparatus

  1983cited by this paper
• Circulating immune complexes containing IgA, IgG and IgM in patients with primary IgA nephropathy and with Henoch-Schoenlein nephritis. Correlation with clinical and histologic signs of activity.

  1982cited by this paper
• Origin of Anti‐Thomsen‐Friedenreich (T) and Tn Agglutinins in Man and in White Leghorn Chicks

  1981influential reference
• Comparative frequencies of anti-IgA antibodies among patients with anaphylactic transfusion reactions and among normal blood donors.

  1977cited by this paper
• Naturally occurring human antibodies to pepsin-digested IgA.

  1970cited by this paper
• [Intercapillary deposits of IgA-IgG].

  1968cited by this paper

• Efficacy and safety of budesonide for the treatment of IgA nephropathy: a systematic review and meta-analysis.

  2026cites this paper
• Serum steroid metabolome pattern is associated with the response to prednisolone therapy of male patients with IgA nephropathy

  2025cites this paper
• IgA nephropathy with monotypic IgA-κ deposits: a case report and literature review

  2025cites this paper
• Proteomic Insights into IgA Nephropathy: A Comprehensive Analysis of Differentially Expressed Proteins in the Kidney

  2025cites this paper
• Network Pharmacological Analysis of Hydroxychloroquine Intervention in the Treatment of Iga Nephropathy

  2024cites this paper
• GalNAc-T14 may Contribute to Production of Galactose-Deficient Immunoglobulin A1, the Main Autoantigen in IgA Nephropathy

  2023cites this paper
• Identification of IgA autoantibodies targeting mesangial cells redefines the pathogenesis of IgA nephropathy

  2023cites this paper
• Current knowledge of targeted-release budesonide in immunoglobulin A nephropathy: A comprehensive review

  2023cites this paper
• IL-6 and its role in IgA nephropathy development.

  2022cites this paper
• Unraveling the Mechanism of Zhibaidihuang Decoction against IgA Nephropathy Using Network Pharmacology and Molecular Docking Analyses.

  2022cites this paper
• Exploratory application of an integrated topic‐based curriculum in biochemistry experimental teaching

  2022cites this paper
• Galactose-Deficient IgA1 B cells in the Circulation of IgA Nephropathy Patients Carry Preferentially Lambda Light Chains and Mucosal Homing Receptors

  2022influential citation
• The Role of Renal Macrophage, AIM, and TGF-β1 Expression in Renal Fibrosis Progression in IgAN Patients

  2021cites this paper
• Serum IgA/C3 ratio and glomerular C3 staining predict progression of IgA nephropathy in children

  2021cites this paper
• Alleviation of refractory IgA nephropathy by intensive fecal microbiota transplantation: the first case reports

  2021cites this paper
• Pathogenesis of IgA Nephropathy: Current Understanding and Implications for Development of Disease-Specific Treatment

  2021cites this paper
• Overview of Traditional Chinese and Western Medicine Treatment of IgA Nephropathy

  2021cites this paper
• Tonsillar immunology in IgA nephropathy.

  2020cites this paper
• Title Page Immunoproteasome in IgA Nephropathy: State-of-Art and Future Perspectives

  2020cites this paper
• Upregulation of microRNA-140-3p mediates dachshund family transcription factor 1 expression in immunoglobulin A nephropathy through cell cycle-dependent mechanisms

  2020cites this paper
• Long-Term Risk of Comorbidity after IgA Vasculitis in Childhood: A Population-Based Cohort Study

  2020cites this paper
• IgA Nephropathies in Children: Epidemiological, Clinical, Histological and Evolutionary Profile: About 31 Cases

  2020influential citation
• Immunoproteasome in IgA Nephropathy: State-of-Art and Future Perspectives

  2020cites this paper
• Serum complement C4 is an important prognostic factor for IgA nephropathy: a retrospective study

  2019cites this paper
• Update on the etiology, classification, and management of glomerular diseases

  2019cites this paper
• Chronic kidney disease: a review of proteomic and metabolomic approaches to membranous glomerulonephritis, focal segmental glomerulosclerosis, and IgA nephropathy biomarkers

  2019influential citation
• T Follicular Regulatory Cells Promote the Germinal Center Reaction and Allergic IgE Response While Repressing Abnormal Differentiation of T Follicular Helper Cells

  2019cites this paper
• Role of microtubule-associated protein 6 glycosylated with Gal-(β-1,3)-GalNAc in Parkinson's disease

  2019cites this paper
• T cells in IgA nephropathy: role in pathogenesis, clinical significance and potential therapeutic target

  2018cites this paper
• Secondary IgA nephropathy.

  2018cites this paper
• Unexpected Help: Follicular Regulatory T Cells in the Germinal Center

  2018cites this paper