Reduction of perforin, granzyme B, and cytokine interferon gamma by ethanol in male Fischer 344 rats.

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Alcoholism: Clinical and Experimental Research

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  PMID 12711929
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Evidence for the role of natural immunity in the control of metastatic spread of head and neck cancer

  2004cited by this paper
• Reduced alloreactive T-cell activation after alcohol intake is due to impaired monocyte accessory cell function and correlates with elevated IL-10, IL-13, and decreased IFNgamma levels.

  2001cited by this paper
• Chronic Ethanol Inhibits NK Cell Cytolytic Activity: Role of Opioid Peptide β-Endorphin1

  2001cited by this paper
• Perforin and interferon-gamma activities independently control tumor initiation, growth, and metastasis.

  2001cited by this paper
• Mechanisms of suppression of poly I:C-induced activation of NK cells by ethanol.

  2000cited by this paper
• Distinct patterns of cytokine gene suppression by the equivalent effective doses of cyclosporine and tacrolimus in rat heart allografts.

  2000cited by this paper
• Functional Defects of NK Cells Treated with Chloroquine Mimic the Lytic Defects Observed in Perforin-Deficient Mice1

  2000cited by this paper
• Costimulation of human natural killer cells is required for interferon gamma production.

  1999cited by this paper
• Modulation of perforin, granzyme A, and granzyme B in murine natural killer (NK), IL2 stimulated NK, and lymphokine-activated killer cells by alcohol consumption.

  1999cited by this paper
• How do cytotoxic lymphocytes kill their targets?

  1998cited by this paper
• Differential cytokine regulation of natural killer cell‐mediated necrotic and apoptotic cytotoxicity

  1998cited by this paper
• In Vitro– and Ex Vivo–derived Cytolytic Leukocytes from Granzyme A × B Double Knockout Mice Are Defective in Granule-mediated Apoptosis but not Lysis of Target Cells

  1997cited by this paper
• Involvement of catecholamines and glucocorticoids in ethanol-induced suppression of splenic natural killer cell activity in a mouse model for binge drinking.

  1997cited by this paper
• Suppression of splenic natural killer cell activity in a mouse model for binge drinking. II. Role of the neuroendocrine system.

  1996cited by this paper
• Suppression of splenic natural killer cell activity in a mouse model for binge drinking. I. Direct effects of ethanol and its major metabolites are not primarily responsible for decreased natural killer cell activity.

  1996cited by this paper
• Characterization of early IL-12, IFN-alphabeta, and TNF effects on antiviral state and NK cell responses during murine cytomegalovirus infection.

  1996cited by this paper
• The roles of perforin‐ and Fas‐dependent cytotoxicity in protection against cytopathic and noncytopathic viruses

  1995cited by this paper
• Execution and suicide: cytotoxic lymphocytes enforce Draconian laws through separate molecular pathways.

  1995cited by this paper
• Perforin: structure and function.

  1995cited by this paper
• Natural killer and lymphokine-activated killer cells require granzyme B for the rapid induction of apoptosis in susceptible target cells.

  1995cited by this paper
• Characterization of a chemically induced tumor model and the effects of natural killer cell depletion by antiasialo GM-1.

  1994cited by this paper
• Alcohol, immunomodulation, and disease.

  1994cited by this paper
• Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice

  1994cited by this paper
• Ethanol decreases the number and activity of splenic natural killer cells in a mouse model for binge drinking.

  1994cited by this paper
• Cell-mediated cytotoxicity.

  1993cited by this paper
• Natural killer cell activity in laryngeal carcinoma.

  1993cited by this paper
• Substrate‐specific proteases (BLT‐esterase) are localized predominantly in the natural killer cells of unprimed mice

  1993cited by this paper
• Ethanol modulation of tumor necrosis factor and gamma interferon production by murine splenocytes and macrophages.

  1993cited by this paper
• Multiple defects of immune cell function in mice with disrupted interferon-gamma genes.

  1993cited by this paper
• Ethanol-induced changes in peripheral blood and splenic natural killer cells.

  1993cited by this paper
• Interferon—A Major Regulator of Natural Killer Cell-Mediated Cytotoxicity

  1993cited by this paper
• Modulation of perforin and granzyme messenger RNA expression in human natural killer cells.

  1993cited by this paper
• Ethanol increases tumor progression in rats: possible involvement of natural killer cells.

  1992cited by this paper
• Effects of alcohol consumption on DNA methylation reactions and gene expression: implications for increased cancer risk

  1992cited by this paper
• Purification of three cytotoxic lymphocyte granule serine proteases that induce apoptosis through distinct substrate and target cell interactions

  1992cited by this paper
• Differential expression of granzyme A and granzyme B proteases and their secretion by fresh rat natural killer cells (NK) and lymphokine‐activated killer cells with NK phenotype (LAK‐NK)

  1992cited by this paper
• The function of lymphocyte proteases. Inhibition and restoration of granule-mediated lysis with isocoumarin serine protease inhibitors.

  1991cited by this paper
• Killer T's, macrophages, and NK's. The Fourth International Cell-Mediated Cytotoxicity Workshop, sponsored by the Pittsburgh CancerInstitute, and the University of Pittsburgh Medical Health Care Division, Oglebay Park, WV, USA, June 10-13, 1990.

  1990cited by this paper
• Alcohol and cancer.

  1990cited by this paper
• Evaluation of interferon system among chronic alcoholics.

  1990cited by this paper
• Characterization of three serine esterases isolated from human IL-2 activated killer cells.

  1988cited by this paper
• Ethanol, immunomodulation and cancer.

  1988cited by this paper
• Depletion of natural killer cells in mice by monoclonal antibody to NK-1.1. Reduction in host defense against malignancy without loss of cellular or humoral immunity.

  1987cited by this paper
• Lymphocyte granule-mediated cytolysis requires serine protease activity.

  1987cited by this paper
• Generation of mouse natural killer (NK) cell activity: Effect of interleukin‐2 (IL‐2) and interferon (IFN) on the in vivo development of natural killer cells from bone marrow (BM) progenitor cells

  1986cited by this paper
• The role of natural killer cells in the control of tumor growth and metastasis.

  1985cited by this paper
• Role of organ-associated NK cells in decreased formation of experimental metastases in lung and liver.

  1985cited by this paper
• Interleukin-2 augments natural killer cell activity

  1981cited by this paper
• The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today.

  1981cited by this paper
• The dietary environment and cancer.

  1977cited by this paper
• Association of cancer sites with tobacco and alcohol consumption and socioeconomic status of patients: interview study from the Third National Cancer Survey.

  1977cited by this paper
• A case-control investigation of alcohol, tobacco, and diet in head and neck cancer.

  1975cited by this paper
• Unexpected high incidence of primary liver cancer in Geneva, Switzerland.

  1975cited by this paper
• The effect of joint exposure to alcohol and tobacco on risk of cancer of the mouth and pharynx.

  1972cited by this paper

• The mechanisms underlying alcohol-induced decreased splenic size: A network meta-analysis study.

  2023cites this paper
• Alcohol: Immunomodulatory Effects and Cancer.

  2023cites this paper
• Cumulative arsenic exposure is associated with fungal infections: Two cohort studies based on southwestern and northeastern basins in Taiwan.

  2016cites this paper
• A dynamic flux in natural killer cell subsets as a function of the duration of alcohol ingestion.

  2012influential citation
• Alcohol intake and risk of aggressive histological basal cell carcinoma: a case-control study.

  2012cites this paper
• Effect of low ethanol concentrations on the production and stability of Interferon gamma

  2008cites this paper
• The Long‐term Impaired Macrophages Functions are Already Observed Early after High‐dose Ethanol Administration

  2008cites this paper
• Neuroendocrine-immune correlates of circadian physiology: studies in experimental models of arthritis, ethanol feeding, aging, social isolation, and calorie restriction

  2007cites this paper
• Ethanol suppression of the hypothalamic proopiomelanocortin level and the splenic NK cell cytolytic activity is associated with a reduction in the expression of proinflammatory cytokines but not anti-inflammatory cytokines in neuroendocrine and immune cells.

  2006cites this paper
• Dibutyltin exposure decreases granzyme B and perforin in human natural killer cells.

  2005cites this paper
• Alcohol suppresses IL-2-induced CC chemokine production by natural killer cells.

  2005cites this paper
• Role of natural killer cells in immunotoxicity: an update

  2005cites this paper
• Studies of the global gene expression changes in alcoholic human brain and blood

  2005cites this paper
• Effects of interleukins 2 and 12 on the levels of granzyme B and perforin and their mRNAs in tributyltin-exposed human natural killer cells

  2005cites this paper
• Beta-endorphin modulation of interferon-gamma, perforin and granzyme B levels in splenic NK cells: effects of ethanol.

  2005cites this paper
• Modulation of hypothalamic beta-endorphin-regulated expression of natural killer cell cytolytic activity regulatory factors by ethanol in male Fischer-344 rats.

  2004cites this paper
• Tributyltin exposure causes decreased granzyme B and perforin levels in human natural killer cells.

  2004cites this paper
• Catecholaminergic control of NK cell cytolytic activity regulatory factors in the spleen.

  2004cites this paper
• CHRONIC ETHANOL CONSUMPTION INHIBITS MULTIPLE APOPTOTIC PATHWAYS IN THE RAT PANCREATIC ACINAR CELL

  2003influential citation