Excitatory effects of low‐level lead exposure on action potential firing of pyramidal neurons in CA1 region of rat hippocampal slices

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Journal of Neuroscience Research

• Publication date

  2008-12-01

• Fields of study

  Medicine, Chemistry, Environmental Science

• Identifiers
  DOI 10.1002/jnr.21804PMID 18683240
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Molecular targets of lead in brain neurotoxicity

  2009cited by this paper
• [Effect of lead on learn and memory and release of intracellular free Ca2+ from calcium pool in dissociated mouse hippocampal neurons].

  2005cited by this paper
• Effects of lead on voltage-gated sodium channels in rat hippocampal CA1 neurons.

  2005cited by this paper
• Effects of Toxic Environmental Contaminants on Voltage-Gated Calcium Channel Function: From Past to Present

  2003cited by this paper
• Lead neurotoxicity in children: basic mechanisms and clinical correlates.

  2003cited by this paper
• Excitatory action of lead on rat sympathetic preganglionic neurons in vitro and in vivo.

  2002cited by this paper
• Lead, unsafe at any level.

  2002cited by this paper
• Characteristics of block by Pb2+ of function of human neuronal L-, N-, and R-type Ca2+ channels transiently expressed in human embryonic kidney 293 cells.

  2002cited by this paper
• Multiple pathways of Pb2+ permeation in rat cerebellar granule neurones

  2001cited by this paper
• The effects of lead on transient outward currents of acutely dissociated rat dorsal root ganglia.

  2001cited by this paper
• Lead increases tetrodotoxin-insensitive spontaneous release of glutamate and GABA from hippocampal neurons.

  1999cited by this paper
• Molecular Mechanisms of Lead Neurotoxicity

  1999cited by this paper
• Nanomolar concentrations of lead inhibit glutamatergic and GABAergic transmission in hippocampal neurons.

  1999cited by this paper
• Multiple mechanisms of spike-frequency adaptation in motoneurones.

  1999cited by this paper
• Low-level lead-induced neurotoxicity in children: an update on central nervous system effects.

  1998cited by this paper
• Effect of chelation with meso-dimercaptosuccinic acid (DMSA) before and after the appearance of lead-induced neurotoxicity in the rat.

  1997cited by this paper
• Full reversal of Pb++ block of L-type Ca++ channels requires treatment with heavy metal antidotes.

  1997influential reference
• The Role of K+ Currents in Frequency-Dependent Spike Broadening in Aplysia R20 Neurons: A Dynamic-Clamp Analysis

  1996cited by this paper
• Electroresponsive properties and membrane potential trajectories of three types of inspiratory neurons in the newborn mouse brain stem in vitro.

  1996cited by this paper
• Relationships between lead-induced learning impairments and changes in dopaminergic, cholinergic, and glutamatergic neurotransmitter system functions.

  1995cited by this paper
• Mammalian voltage-activated calcium channel currents are blocked by Pb2+, Zn2+, and Al3+.

  1994cited by this paper
• Impairment of long-term potentiation and learning following chronic lead exposure.

  1993cited by this paper
• Low-level lead exposure, intelligence and academic achievement: a long-term follow-up study.

  1992cited by this paper
• Lead and zinc block a voltage-activated calcium channel of Aplysia neurons.

  1991cited by this paper
• Long-term potentiation in rat hippocampal slices is impaired following acute lead perfusion.

  1991cited by this paper
• Reduction of glutamine synthetase activity in astroglia exposed in culture to low levels of inorganic lead.

  1991cited by this paper
• Low-level lead exposure and children's cognitive function in the preschool years.

  1991cited by this paper
• Effect of lead on intracellular free calcium ion concentration in a presynaptic neuronal model: 19F-NMR study of NG108-15 cells.

  1989cited by this paper
• Picomolar concentrations of lead stimulate brain protein kinase C

  1988cited by this paper
• Acute lead exposure transiently inhibits hippocampal neuronal activities in vitro.

  1988cited by this paper
• Electrophysiology of Hippocampal Neurons

  1987cited by this paper
• Longitudinal analyses of prenatal and postnatal lead exposure and early cognitive development.

  1987cited by this paper
• Lead toxicity in primary cultured cerebral astrocytes and cerebellar granular neurons.

  1987cited by this paper
• The effect of pre- or postnatal lead exposure on Hamilton Search Task in monkeys.

  1983cited by this paper
• Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

  1981cited by this paper
• Mechanism of frequency‐dependent broadening of molluscan neurone soma spikes.

  1979cited by this paper
• Electrophysiology of hippocampal neurons. II. After-potentials and repetitive firing.

  1961cited by this paper

• A high dose of 2-APB enhances neurotoxicity induced by 6-hydroxydopamine in rats

  2025cites this paper
• Long‐term consequences of early postnatal lead exposure on hippocampal synaptic activity in adult mice

  2019cites this paper
• AFRL-SA-WP-TR-2017-0013 Cellular Sentinels Toxicity Platform

  2017cites this paper
• Cellular Sentinels Toxicity Platform

  2017cites this paper
• The History, Status, Gaps, and Future Directions of Neurotoxicology in China

  2016cites this paper
• Epigenetic histone modification regulates developmental lead exposure induced hyperactivity in rats.

  2014cites this paper
• TRPC1 is involved in Ca²⁺ influx and cytotoxicity following Pb²⁺ exposure in human embryonic kidney cells.

  2014cites this paper
• Exposure to Environmental Toxicants and Pathogenesis of Amyotrophic Lateral Sclerosis: State of the Art and Research Perspectives

  2013cites this paper
• Modulation of low-voltage-activated T-type Ca²⁺ channels.

  2013cites this paper
• Genetics of amyotrophic lateral sclerosis

  2012cites this paper
• Lead and developmental neurotoxicity of the central nervous system

  2011cites this paper
• Neuroprotection by lomerizine, a prophylactic drug for migraine, against hydrogen peroxide-induced hippocampal neurotoxicity

  2011cites this paper
• Neuronal T–type calcium channels: What's new? Iftinca: T–type channel regulation

  2011cites this paper
• Regulation of neuronal T-type calcium channels.

  2009cites this paper
• The role of environmental mercury, lead and pesticide exposure in development of amyotrophic lateral sclerosis.

  2009cites this paper