Cytogenetic Analysis of Male Infertility

In order to assess the significance of chromosome abnormalities and polymorphic chromosomal variants in male infertility, the results of cytogenetic studies of 70 patients (16 azoospermic and 54 oligozoospermic men) were compared with those of 35 control fertile men. Total chromosome alterations were revealed in 31% of infertile men. Major chromosomal abnormalities had a 10-fold increase in infertile males compared to the control group. In azoospermics, the most prevalent were sex chromosomal abnormalities (47, XXY) (22.7%); mosaicism that is 47, XXY/48, XXYY was seen in one patient. One patient showed 46, XX karyotype and variations in Y chromosome was identified. Whereas in oligozoospemric men polymorphic variations were observed in chromosome 1, 9, Y and presence of satellite in chromosome 15 and 21 and robertsonian translocation (13/14) were also identified. The most frequently observed polymorphisms involved chromosome 9. In conclusion, chromosomal abnormalities found with a high frequency in infertile males are a major cause of male infertility and justify the requirement of cytogenetic analysis in every infertile man.

• Publication year

  2015

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  Unknown venue

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

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  Open on Semantic Scholar

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  Semantic Scholar

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• No concepts are published for this paper.

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