Identifying accurate biomarkers of cognitive decline is essential for advancing early diagnosis and prevention therapies in Alzheimer's disease. The Alzheimer's disease DREAM Challenge was designed as a computational crowdsourced project to benchmark the current state‐of‐the‐art in predicting cognitive outcomes in Alzheimer's disease based on high dimensional, publicly available genetic and structural imaging data. This meta‐analysis failed to identify a meaningful predictor developed from either data modality, suggesting that alternate approaches should be considered for prediction of cognitive performance.
Crowdsourced estimation of cognitive decline and resilience in Alzheimer's disease
Genevera I. Allen,N. Amoroso,Catalina V. Anghel,V. Balagurusamy,Chris Bare,D. Beaton,R. Bellotti,D. Bennett,Kevin L. Boehme,P. Boutros,L. Caberlotto,Cristian Caloian,F. Campbell,E. C. Neto,Yu-Chuan Chang,Beibei Chen,Chien-Yu Chen,T.-Y. Chien,Tim Clark,Sudeshna Das,C. Davatzikos,J. Deng,Donna E. Dillenberger,R. Dobson,Qilin Dong,J. Doshi,Denise Duma,R. Errico,G. Erus,E. Everett,D. Fardo,S. Friend,H. Fröhlich,J. Gan,P. George-Hyslop,Satrajit S. Ghosh,E. Glaab,R. Green,Y. Guan,Ming-Yi Hong,Chao Huang,Jinseub Hwang,J. Ibrahim,P. Inglese,Anandhi Iyappan,Qijia Jiang,Y. Katsumata,J. Kauwe,A. Klein,Dehan Kong,R. Krause,Emilie Lalonde,Mario Lauria,Eunjee Lee,Xihui Lin,Zhandong Liu,J. Livingstone,Benjamin A. Logsdon,S. Lovestone,Tsung-wei Ma,Ashutosh Malhotra,L. Mangravite,Taylor J. Maxwell,Emily Merrill,John Nagorski,A. Namasivayam,Manjari Narayan,Mufassra Naz,S. Newhouse,Thea C. Norman,R. Nurtdinov,Yen-Jen Oyang,Y. Pawitan,Shengwen Peng,M. Peters,Stephen R. Piccolo,Paurush Praveen,C. Priami,Veronica Y. Sabelnykova,Philipp Senger,Xia Shen,A. Simmons,Aristeidis Sotiras,G. Stolovitzky,S. Tangaro,A. Tateo,Yi-An Tung,N. Tustison,E. Varol,G. Vradenburg,M. Weiner,Guanghua Xiao,Lei Xie,Yang Xie,Jia Xu,Hojin Yang,Xiaowei Zhan,Yunyun Zhou,Fan Zhu,Hongtu Zhu,Shanfeng Zhu
Published 2016 in Alzheimer's & Dementia
ABSTRACT
PUBLICATION RECORD
- Publication year
2016
- Venue
Alzheimer's & Dementia
- Publication date
2016-06-01
- Fields of study
Medicine, Computer Science
- Identifiers
- External record
- Source metadata
Semantic Scholar, PubMed
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