Antioxidant Activity of Hemidesmus Indicus ( L . ) R . Br . Encapsulated poly ( lactide-co-glycolide ) ( PLGA ) Nanoparticles

Hemidesmus indicus (HI) belonging to the family Asclepediaceae has been used in Indian system of traditional medicine. The study was aimed to synthesize and characterize the aqueous root extract of HI encapsulated poly (lactide-co-glycolide) (PLGA) nanoparticles and further evaluate its antioxidant properties. The root extract was encapsulated on PLGA by solid-in-oil-water solvent evaporation method to improve the solubility, permeability and stability of the compounds in the extract. Physicochemical properties were characterized by Scanning Electron Microscope, X-ray diffraction and Fourier Transform Infrared techniques. The antioxidant properties of free and encapsulated root extract were determined by DPPH, Superoxide and Hydroxyl radical scavenging assays. The PLGA encapsulated nanoparticles showed reduction in their IC50 values in all the assays. The information obtained for this study facilitates the design and fabrication of polymeric nanoparticles as possible drug delivery system and therapeutic applications.

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