Enhanced clearance of herpes simplex virus type 1 and reduced herpetic eye disease in STAT6 knockout mice is associated with increased IL-2.

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Virology

• Publication date

  2002-10-25

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1006/VIRO.2002.1611PMID 12441072
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Both CD4+ and CD8+ T cells are involved in protection against HSV-1 induced corneal scarring

  2000cited by this paper
• Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production.

  1999cited by this paper
• The role of interleukin (IL)-2 and IL-4 in herpes simplex virus type 1 ocular replication and eye disease.

  1999cited by this paper
• Perforin pathway is essential for protection of mice against lethal ocular HSV-1 challenge but not corneal scarring.

  1999cited by this paper
• Use of recombinant viruses to deliver cytokines influencing the course of experimental bacterial infection

  1999cited by this paper
• The IL-4 receptor: signaling mechanisms and biologic functions.

  1999cited by this paper
• DNA inoculations with HIV-1 recombinant genomes that express cytokine genes enhance HIV-1 specific immune responses.

  1999cited by this paper
• Either a CD4(+)or CD8(+)T cell function is sufficient for clearance of infectious virus from trigeminal ganglia and establishment of herpes simplex virus type 1 latency in mice.

  1999cited by this paper
• Vaccination with different HSV-1 glycoproteins induces different patterns of ocular cytokine responses following HSV-1 challenge of vaccinated mice.

  1999cited by this paper
• The role of neutralizing antibody and T‐helper subtypes in protection and pathogenesis of vaccinated mice following ocular HSV‐1 challenge

  1998cited by this paper
• Interleukin-13: central mediator of allergic asthma

  1998cited by this paper
• Mice with STAT6-targeted gene disruption develop a Th1 response and control cutaneous leishmaniasis.

  1998cited by this paper
• Th2 cells are required for the Schistosoma mansoni egg-induced granulomatous response.

  1998cited by this paper
• IL-13, IL-4Ralpha, and Stat6 are required for the expulsion of the gastrointestinal nematode parasite Nippostrongylus brasiliensis.

  1998cited by this paper
• Interleukin-13: central mediator of allergic asthma.

  1998cited by this paper
• STAT6: its role in interleukin 4-mediated biological functions

  1997cited by this paper
• The importance of MHC‐I and MHC‐II responses in vaccine efficacy against lethal herpes simplex virus type 1 challenge

  1997cited by this paper
• Overexpression of interleukin-4 delays virus clearance in mice infected with respiratory syncytial virus

  1997cited by this paper
• Stat4- and Stat6-deficient mice as models for manipulating T helper cell responses.

  1997cited by this paper
• Risk factors for herpes simplex virus epithelial keratitis recurring during treatment of stromal keratitis or iridocyclitis. Herpetic Eye Disease Study Group.

  1996cited by this paper
• Interleukin-4 causes delayed virus clearance in influenza virus-infected mice

  1996cited by this paper
• Induction of a protective immune response by mucosal vaccination with a DISC HSV-1 vaccine.

  1996cited by this paper
• Role of interferon‐γ in immunity to herpes simplex virus

  1996cited by this paper
• Impaired IL-13-mediated functions of macrophages in STAT6-deficient mice.

  1996cited by this paper
• Immunoglobulin class switching.

  1996cited by this paper
• Gamma interferon expression during acute and latent nervous system infection by herpes simplex virus type 1

  1995cited by this paper
• Local expression of tumor necrosis factor alpha and interleukin-2 correlates with protection against corneal scarring after ocular challenge of vaccinated mice with herpes simplex virus type 1

  1995cited by this paper
• Protection against herpes simplex virus-induced eye disease after vaccination with seven individually expressed herpes simplex virus 1 glycoproteins.

  1995cited by this paper
• An Essential Role for Type 1 Interferon-γ in Terminating Persistent Viral Infection

  1995cited by this paper
• An essential role for type 1 interferon-gamma in terminating persistent viral infection.

  1995cited by this paper
• The Th1/Th2 balance in autoimmunity.

  1995cited by this paper
• Control of acute cutaneous herpes simplex virus infection: T cell-mediated viral clearance is dependent upon interferon-gamma (IFN-gamma).

  1994cited by this paper
• Control of acute cutaneous herpes simplex virus infection : T cell-mediated viral clearance is dependent upon interferon-γ (IFN-γ)

  1994cited by this paper
• Expression of seven herpes simplex virus type 1 glycoproteins (gB, gC, gD, gE, gG, gH, and gI): comparative protection against lethal challenge in mice

  1994cited by this paper
• Lymphocyte responses and cytokines.

  1994cited by this paper
• Herpetic eye disease study : a controlled trial of oral acyclovir for herpes simplex stromal keratitis

  1994cited by this paper
• Mechanism of virus-induced Ig subclass shifts.

  1994cited by this paper
• Inhibition of viral replication by interferon-gamma-induced nitric oxide synthase.

  1993cited by this paper
• Disruption of the murine IL-4 gene blocks Th2 cytokine responses

  1993cited by this paper
• IFN-gamma and IL-2 are protective in the skin but pathologic in the corneas of HSV-1-infected mice.

  1992cited by this paper
• Immunoglobulin A mediation of murine nasal anti-influenza virus immunity

  1991cited by this paper
• Cyclosporin A inhibition of interleukin 2 gene expression, but not natural killer cell proliferation, after interferon induction in vivo

  1990cited by this paper
• Treatment with monoclonal anti-CD3 antibody protects against lethal Sendai virus infection by induction of natural killer cells.

  1990cited by this paper
• TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties.

  1989cited by this paper
• Bovine recombinant interleukin-2 augments immunity and resistance to bovine herpesvirus infection.

  1989cited by this paper
• Recombinant interleukin 2 as an adjuvant for vaccine-induced protection. Immunization of guinea pigs with herpes simplex virus subunit vaccines.

  1988cited by this paper
• Detection of latency-related viral RNAs in trigeminal ganglia of rabbits latently infected with herpes simplex virus type 1

  1987cited by this paper
• Herpes simplex virus isolation in chronic stromal keratitis: human and laboratory studies.

  1987cited by this paper
• A Review of the Treatment of Ocular Herpes Simplex Infections in the Neonate and Immunocompromised Host

  1984cited by this paper
• Ocular herpes simplex virus infections.

  1984cited by this paper
• Role of mouse IgG and IgE homocytotropic antibodies in passive cutaneous anaphylaxis.

  1977cited by this paper
• Herpes simplex eye infections: clinical manifestations, pathogenesis and management.

  1976cited by this paper
• Latent herpetic infections following experimental viraemia.

  1976cited by this paper

• STAT6‐induced production of mucus and resistin‐like molecules in lung Club cells does not protect against helminth or influenza A virus infection

  2023cites this paper
• The Dynamic Interface of Viruses with STATs

  2020cites this paper
• Trichuris muris whey acidic protein induces type 2 protective immunity against whipworm

  2018cites this paper
• Involvement of STAT4 in IgG subtype switching and ocular HSV-1 replication in mice

  2010influential citation
• Immunomodulatory roles of topical dinitrochlorobenzene treatment in Herpes simplex virus infection.

  2009cites this paper
• Improved protection from primary ocular HSV-1 infection and establishment of latency using multigenic DNA vaccines.

  2004cites this paper