The significance of molecular slips in transport systems

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Nature reviews. Molecular cell biology

• Publication date

  2002-11-01

• Fields of study

  Biology, Medicine, Computer Science

• Identifiers
  DOI 10.1038/nrm955PMID 12415305
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2000cited by this paper
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  2000cited by this paper
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  1999cited by this paper
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• Molecular Rotary Motors

  1999cited by this paper
• Undetectable intracellular free copper: the requirement of a copper chaperone for superoxide dismutase.

  1999cited by this paper
• Molecular architecture of the rotary motor in ATP synthase.

  1999cited by this paper
• Modular control analysis of slipping enzymes.

  1999cited by this paper
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  1999cited by this paper
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  1994cited by this paper
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• [Electron microscopy].

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  2003cites this paper
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  2003cites this paper
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  2003cites this paper
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  year unknowncites this paper