Catching Functional Modes and Structural Communication in Dbl Family Rho Guanine Nucleotide Exchange Factors

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Journal of Chemical Information and Modeling

• Publication date

  2015-09-14

• Fields of study

  Biology, Medicine, Chemistry, Computer Science

• Identifiers
  DOI 10.1021/acs.jcim.5b00122PMID 26322553
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• WebPSN: a web server for high-throughput investigation of structural communication in biomacromolecules

  2015cited by this paper
• University of Birmingham Structural insights into the activation of the RhoA GTPase by the Lymphoid blast crisis (Lbc) oncoprotein

  2014cited by this paper
• Rho guanine nucleotide exchange factors: regulators of Rho GTPase activity in development and disease

  2014cited by this paper
• COSMIC: exploring the world's knowledge of somatic mutations in human cancer

  2014cited by this paper
• The crystal structure of the RhoA–AKAP-Lbc DH–PH domain complex

  2014cited by this paper
• A conformational switch in collybistin determines the differentiation of inhibitory postsynapses

  2014cited by this paper
• Light on the structural communication in Ras GTPases

  2013cited by this paper
• A Mixed Protein Structure Network and Elastic Network Model Approach to Predict the Structural Communication in Biomolecular Systems: The PDZ2 Domain from Tyrosine Phosphatase 1E As a Case Study.

  2013cited by this paper
• Structural basis for autoinhibition of the guanine nucleotide exchange factor FARP2.

  2013cited by this paper
• Structural Determinants of RGS‐RhoGEF Signaling Critical to Entamoeba histolytica Pathogenesis

  2013cited by this paper
• Structural Insights into the Activation of the RhoA GTPase by the Lymphoid Blast Crisis (Lbc) Oncoprotein

  2013cited by this paper
• Interaction Signatures Stabilizing the NAD(P)-Binding Rossmann Fold: A Structure Network Approach

  2012cited by this paper
• Amplification of Thymosin Beta 10 and AKAP13 Genes in Metastatic and Aggressive Papillary Thyroid Carcinomas

  2012cited by this paper
• Activation of p115-RhoGEF Requires Direct Association of Gα13 and the Dbl Homology Domain*

  2012cited by this paper
• Mechanistic Insights into Specificity, Activity, and Regulatory Elements of the Regulator of G-protein Signaling (RGS)-containing Rho-specific Guanine Nucleotide Exchange Factors (GEFs) p115, PDZ-RhoGEF (PRG), and Leukemia-associated RhoGEF (LARG)*

  2011cited by this paper
• Wordom: A User-Friendly Program for the Analysis of Molecular Structures, Trajectories, and Free Energy Surfaces

  2010cited by this paper
• The Minimal Autoinhibited Unit of the Guanine Nucleotide Exchange Factor Intersectin

  2010cited by this paper
• Deciphering the deformation modes associated with function retention and specialization in members of the Ras superfamily.

  2010cited by this paper
• Structural and energetic mechanisms of cooperative autoinhibition and activation of Vav1.

  2010cited by this paper
• Conservation and variation of structural flexibility in protein families.

  2010cited by this paper
• Normal mode analysis of biomolecular structures: functional mechanisms of membrane proteins.

  2010cited by this paper
• Structure and Function of Heterotrimeric G Protein-Regulated Rho Guanine Nucleotide Exchange Factors

  2010cited by this paper
• Intra and inter-molecular communications through protein structure network.

  2009cited by this paper
• The solution structure and dynamics of the DH‐PH module of PDZRhoGEF in isolation and in complex with nucleotide‐free RhoA

  2009cited by this paper
• Rho GTPase function in tumorigenesis.

  2009cited by this paper
• Searching protein structure databases with DaliLite v.3

  2008cited by this paper
• The DH and PH domains of Trio coordinately engage Rho GTPases for their efficient activation.

  2007cited by this paper
• Structure of Gαq-p63RhoGEF-RhoA Complex Reveals a Pathway for the Activation of RhoA by GPCRs

  2007cited by this paper
• Crystal Structure of the Rac Activator, Asef, Reveals Its Autoinhibitory Mechanism*

  2007cited by this paper
• Interpreting correlated motions using normal mode analysis.

  2006cited by this paper
• Association of genetic variants in the Rho guanine nucleotide exchange factor AKAP13 with familial breast cancer.

  2006cited by this paper
• The crystal structure of Cdc42 in complex with collybistin II, a gephyrin-interacting guanine nucleotide exchange factor.

  2006cited by this paper
• The Molecular Basis of RhoA Specificity in the Guanine Nucleotide Exchange Factor PDZ-RhoGEF*

  2006cited by this paper
• Probing the local dynamics of nucleotide-binding pocket coupled to the global dynamics: myosin versus kinesin.

  2005cited by this paper
• Rho GTPases: biochemistry and biology.

  2005cited by this paper
• GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors

  2005cited by this paper
• Structural elements, mechanism, and evolutionary convergence of Rho protein-guanine nucleotide exchange factor complexes.

  2004cited by this paper
• Global ribosome motions revealed with elastic network model.

  2004cited by this paper
• UCSF Chimera—A visualization system for exploratory research and analysis

  2004cited by this paper
• Pleckstrin Homology Domain-mediated Activation of the Rho-specific Guanine Nucleotide Exchange Factor Dbs by Rac1*

  2004cited by this paper
• A method for simultaneous alignment of multiple protein structures

  2004cited by this paper
• Human RAS Superfamily Proteins and Related GTPases

  2004cited by this paper
• Structural basis for the selective activation of Rho GTPases by Dbl exchange factors

  2002cited by this paper
• Tiam1 mediates Ras activation of Rac by a PI(3)K-independent mechanism

  2002cited by this paper
• PROTEIN STRUCTURE: INSIGHTS FROM GRAPH THEORY

  2002cited by this paper
• Mechanisms through which Sos-1 coordinates the activation of Ras and Rac

  2002cited by this paper
• Interaction of Rac Exchange Factors Tiam1 and Ras-GRF1 with a Scaffold for the p38 Mitogen-Activated Protein Kinase Cascade

  2002cited by this paper
• AKAP-Lbc Anchors Protein Kinase A and Nucleates Gα12-selective Rho-mediated Stress Fiber Formation*

  2001cited by this paper
• Dbl family guanine nucleotide exchange factors.

  2001cited by this paper
• AKAP-Lbc anchors protein kinase A and nucleates Galpha 12-selective Rho-mediated stress fiber formation.

  2001cited by this paper
• Bacterial expressed DH and DH/PH domains.

  2000cited by this paper
• Structural basis for relief of autoinhibition of the Dbl homology domain of proto-oncogene Vav by tyrosine phosphorylation.

  2000cited by this paper
• Building‐block approach for determining low‐frequency normal modes of macromolecules

  2000cited by this paper
• Leukemia‐associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G12 family to Rho

  2000cited by this paper
• Investigating protein dynamics in collective coordinate space.

  1999cited by this paper
• A Novel PDZ Domain Containing Guanine Nucleotide Exchange Factor Links Heterotrimeric G Proteins to Rho*

  1999cited by this paper
• The PH superfold: a structural scaffold for multiple functions.

  1999cited by this paper
• Analysis of domain motions by approximate normal mode calculations

  1998cited by this paper
• Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13.

  1998cited by this paper
• Crystal structure of the Dbl and pleckstrin homology domains from the human Son of sevenless protein.

  1998cited by this paper
• NMR structure and mutagenesis of the N-terminal Dbl homology domain of the nucleotide exchange factor Trio.

  1998cited by this paper
• Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product

  1997cited by this paper
• Direct evaluation of thermal fluctuations in proteins using a single-parameter harmonic potential.

  1997cited by this paper
• Dbl family proteins.

  1997cited by this paper
• The Dbl family of oncogenes.

  1996cited by this paper
• Hinge‐bending motion in citrate synthase arising from normal mode calculations

  1995cited by this paper
• A new approach for determining low‐frequency normal modes in macromolecules

  1994cited by this paper
• A note on two problems in connexion with graphs

  1959cited by this paper

• Allosteric Activation of RhoA Complexed with p115-RhoGEF Deciphered by Conformational Dynamics

  2024cites this paper
• Comparative Protein Structural Network Analysis Reveals C-Terminal Tail Phosphorylation Structural Communication Fingerprint in PTEN-Associated Mutations in Autism and Cancer

  2023cites this paper
• Statistical learning of protein elastic network from positional covariance matrix.

  2023cites this paper
• Wordom update 2: A user-friendly program for the analysis of molecular structures and conformational ensembles

  2023cites this paper
• Structural communication between the GTPase Sec4p and its activator Sec2p: Determinants of GEF activity and early deformations to nucleotide release

  2022cites this paper
• PSNtools for standalone and web-based structure network analyses of conformational ensembles

  2022cites this paper
• Prediction of Protein–Protein Interactions Between Alsin DH/PH and Rac1 and Resulting Protein Dynamics

  2022cites this paper
• Epigenetic alteration of Rho guanine nucleotide exchange Factor 11 (ARHGEF11) in cord blood samples in macrosomia exposed to intrauterine hyperglycemia

  2021cites this paper
• MicroRNA Regulation of the Small Rho GTPase Regulators—Complexities and Opportunities in Targeting Cancer Metastasis

  2020cites this paper
• Dynamics and structural communication in the ternary complex of fully phosphorylated V2 vasopressin receptor, vasopressin, and β-arrestin 1.

  2020cites this paper
• PRECOG: PREdicting COupling probabilities of G-protein coupled receptors

  2019cites this paper
• ARHGEF38 as a novel biomarker to predict aggressive prostate cancer

  2019cites this paper
• Interconnecting Flexibility, Structural Communication, and Function in RhoGEF Oncoproteins

  2019cites this paper
• Signaling by Small GTPases at Cell-Cell Junctions: Protein Interactions Building Control and Networks.

  2018cites this paper
• Activated Rho GTPases in Cancer—The Beginning of a New Paradigm

  2018cites this paper
• Overexpression and clinical significance of IBP in epithelial ovarian carcinoma.

  2018cites this paper
• Intrinsic Dynamics Analysis of a DNA Octahedron by Elastic Network Model

  2017cites this paper
• Structural Determinants of Constitutive Activation of Gα Proteins: Transducin as a Paradigm.

  2017cites this paper
• Dissecting intrinsic and ligand-induced structural communication in the β3 headpiece of integrins.

  2017cites this paper
• Use of network model to explore dynamic and allosteric properties of three GPCR homodimers

  2016cites this paper
• Structure network analysis to gain insights into GPCR function.

  2016cites this paper